RESUMEN
OBJECTIVES: To update and extend the examination of cancer incidence in a cohort of Danish firefighters, now adding 7 years of follow-up and 2766 additional firefighters. The primary focus was directed toward cancer sites that recently contributed to the hazard evaluation conducted by the International Agency for Research on Cancer (IARC). METHODS: The updated cohort consisted of 11,827 male Danish firefighters who were followed up for cancer from 1968 to 2021. Cohort cancer morbidity was compared with a working population reference group, and standardized incidence ratios (SIR) were used for estimation of relative risks, along with 95% confidence intervals (95% CI). RESULTS: Among full-time firefighters, SIR of skin melanoma was 1.30 (95% CI: 1.02-1.66), and SIR = 1.37 (95% CI: 1.02-1.85) for over 5 years of employment. Slightly positive associations were also observed for cancer of the urinary bladder (SIR = 1.16; 95% CI: 0.93-1.45), prostate (SIR = 1.11; 95% CI: 0.97-1.28), and testis (SIR = 1.11; 95% CI: 0.75-1.63). CONCLUSIONS: This updated study provides evidence indicating an elevated risk of skin melanoma in firefighters. Consistent with IARC's evaluation, we also identified positive associations for urinary bladder, prostate, and testis cancer. In contrast, our findings did not suggest an increased risk of colon cancer, non-Hodgkin lymphoma, and mesothelioma. The latter may be due to small numbers in our still relatively young cohort. Continuous follow-up for cancer in firefighters is warranted, including assessment of influence from surveillance bias.
RESUMEN
BACKGROUND: Occupational exposures may play a role in breast cancer etiology, and research focusing on identifying high-risk workplaces is important to advance the understanding and prevention of breast cancer. METHODS: We undertook a population-based nested case-control study among women who were less than 70 years of age and born in Denmark, based on registry data including 38,375 breast cancer cases and 191,875 controls matched on year of birth, with information on lifetime work history. Odds ratios for women ever employed in a job branch were adjusted for socioeconomic status and reproductive variables. RESULTS: Adjusted odds ratios of less than 0.75 were observed for several occupations in agriculture, hunting, forestry, and fishing, while increased risk patterns (odds ratios greater than 1.50) were noted for a number of production occupations, including employment in graphics and printing, and metal and machinery production. In services, several military professions were also associated with a high increased breast cancer risk. CONCLUSIONS: The study shows a variation in the risk of female breast cancer by employment in different industrial and occupational sectors, and suggests that certain occupational exposures, for example, outdoor work, organic solvents, polycyclic aromatic hydrocarbons (PAHs), and night-shift work may play a role in the risk of breast cancer. Further hypothesis-testing studies focusing on these employments with a detailed assessment of specific occupational exposures are warranted.
