Innate immunity response of zafirlukast treated-tilapia during foreign body inflammation.

There is limited knowledge regarding the blockade of cysteinyl leukotriene receptors (CysLTRs) and their effects in teleost fish. The present study investigated the effects of Zafirlukast, antagonist of CysLTR1 receptor, on the foreign body inflammatory reaction in Nile tilapia (Oreochromis niloticus). Zafirlukast-treated tilapia demonstrated a decrease in the formation of multinucleated foreign body giant cells and Langhans cells on the round glass coverslips implanted in the subcutaneous tissue, along with a significant reduction in white blood cell counts and decreased production of reactive oxygen species. There was an increase in serum levels of α2-macroglobulins, as well as a decrease in ceruloplasmin and haptoglobin. Zafirlukast treatment led to a significant decrease in the area of splenic melanomacrophage centers and a reduction in the presence of lipofuscin. These findings highlight the potential anti-inflammatory effects of zafirlukast treatment in tilapia and indicate its action on CysLTR1 receptor, modulating the innate immune response of tilapia during the foreign body reaction. The comprehension of chronic inflammation mechanisms in fish has become increasingly relevant, especially concerning the utilization of biomaterials for vaccine and drug delivery.

Desenvolvimento de uma linha experimental de escala reduzida para produção de biscoitos utilizando uma rede de multi sensores com protocolo ZIG-BEE / Development of a line of experimental scale production of biscuits using a network of sensors with multi protocol ZIG-BEE

Aproximadamente 15% do faturamento das indústrias brasileiras são provenientes da indústria alimentícia, responsáveis por empregar mais de um milhão de pessoas. [...] Para provar a viabilidade da aplicação das tecnologias desenvolvidas na indústria alimentícia, uma linha de produção de biscoitos foi projetada e construída em escala laboratorial, sensores e atuadores que utilizam tecnologia sem fio com protocolo zigbee foram instalados ao longo da linha. Para que se pudesse analisar a temperatura interna do biscoito durante seu assamento, um encapsulamento a base de cimento refratário foi desenvolvido para proteger o nó sensor, permitindo que esse possa acompanhar o biscoito dentro do forno e coletar a temperatura interna do biscoito. Desenvolveu-se também um sensor capaz de captar, em tempo real, dados referente à massa, através da leitura da corrente utilizada pelo motor do misturador, pois esta corrente está relacionada com o torque aplicado à massa. A metodologia proposta comprovou a viabilidade da utilização de sensores sem fio com protocolo zigbee, e mostrou ser possível estimar o ponto ideal da massa através do sistema desenvolvido, iniciar o processo de fabricação automaticamente e controlar todos os processos envolvidos

Approximately 15% of the revenues of Brazilian industries from the food industry is responsible for employing over a million people. For large scale production is necessary for these industries are technologically prepared, however much of the electronic instrumentation and control equipment still requires foreign technology. To keep up with growth and global trends in this area, it is necessary to promote research and technological innovation. These innovations can improve sales to this sector, mainly in health food and fast preparation. By contrast, many of these companies even have departments of research and development, especially regarding the use of information technology to aggregate electronic instrumentation, focusing on food production. That is precisely where it belongs this project aims to develop an experimental production line mini biscuits with electronic monitoring and computing, which can estimate the ideal point of the mass and control the production of biscuits automatically. To prove the feasibility of applying the technologies developed in the food industry, a biscuit production line was designed and built at the laboratory scale, using sensors and actuators with wireless zigbee protocol were installed along the line. In order to examine the internal temperature of the cookie during its baking, a tunnel-based refractory cement is designed to protect the sensor node, allowing it to follow the cookie into the oven and the temperature inside the collecting biscuit. It was also developed a sensor capable of capturing real time data regarding the mass, by reading the current used by the motor of the mixer, since this current is related to the torque applied to the mass. The proposed methodology proved the feasibility of using wireless sensor zigbee-protocol, and shown to be possible to estimate the ideal point of the mass through the system developed, start the manufacturing process and automatically control all processes involved