RESUMEN
OBJECTIVES: We examined whether community translation of an effective evidence-based fall prevention program via standard monetary support can produce a community-wide reduction in fall injuries in older adults and evaluated whether an enhanced version with added technical support and capacity building amplified the fall reduction effect. METHODS: We completed a randomized controlled community trial among adults aged 65 and older in (1) 10 control communities receiving no special resources or guidance on fall prevention, (2) 5 standard support communities receiving modest funding to implement Stepping On, and (3) 5 enhanced support communities receiving funding and technical support. The primary outcome was hospital inpatient and emergency department discharges for falls, examined with Poisson regression. RESULTS: Compared with control communities, standard and enhanced support communities showed significantly higher community-wide reductions (9% and 8%, respectively) in fall injuries from baseline (2007-2008) to follow-up (2010-2011). No significant difference was found between enhanced and standard support communities. CONCLUSIONS: Population-based fall prevention interventions can be effective when implemented in community settings. More research is needed to identify the barriers and facilitators that influence the successful adoption and implementation of fall prevention interventions into broad community practice.
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Accidentes por Caídas/prevención & control , Accidentes por Caídas/estadística & datos numéricos , Anciano , Femenino , Humanos , Masculino , Características de la Residencia/estadística & datos numéricos , Wisconsin/epidemiologíaRESUMEN
The 4-H youth development program of the nation's 109 land-grant universities and the Cooperative Extension System is one of the largest youth development organization in the United States serving approximately six million youth. The 4-H Healthy Living initiative began in 2008 to promote achievement of optimal physical, social, and emotional well-being for youth and families. In 2013, the National 4-H Council sought to identify 4-H Healthy Living programs in the domains of healthy eating and physical activity that adhered to the national 4-H Healthy Living mission and were ready for comprehensive outcome evaluation or replication at a national level. This chapter shares findings from an environmental scan of 4-H programs and (a) identifies programs with evidence of promoting a healthy diet and physical activity, (b) describes program impacts related to healthy diet and physical activity, and (c) clarifies select program characteristics associated with reported healthy eating and/or physical activity outcomes. The RE-AIM evaluation framework is introduced as an effective approach to assessing program impact for 4-H Healthy Living and similar out-of-school time programs.
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Dieta Saludable , Ejercicio Físico , Promoción de la Salud , Evaluación de Programas y Proyectos de Salud , Adolescente , Femenino , Humanos , Masculino , Estados UnidosRESUMEN
There is a tension between 2 alternative approaches to implementing community-based interventions. The evidence-based public health movement emphasizes the scientific basis of prevention by disseminating rigorously evaluated interventions from academic and governmental agencies to local communities. Models used by local health departments to incorporate community input into their planning, such as the community health improvement process (CHIP), emphasize community leadership in identifying health problems and developing and implementing health improvement strategies. Each approach has limitations. Modifying CHIP to formally include consideration of evidence-based interventions in both the planning and evaluation phases leads to an evidence-driven community health improvement process that can serve as a useful framework for uniting the different approaches while emphasizing community ownership, priorities, and wisdom.
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Servicios de Salud Comunitaria/organización & administración , Modelos Teóricos , Investigación Biomédica Traslacional , Investigación Participativa Basada en la Comunidad , Relaciones Comunidad-Institución , Medicina Basada en la Evidencia , Implementación de Plan de Salud , Humanos , Evaluación de Programas y Proyectos de SaludRESUMEN
CONTEXT: Vitamin D therapy for hypoparathyroidism does not restore PTH-dependent renal calcium reabsorption, which can lead to renal damage. An alternative approach, PTH 1-34 administered twice daily, provides acceptable long-term treatment but is associated with nonphysiological serum calcium fluctuation. OBJECTIVE: Our objective was to compare continuous PTH 1-34 delivery, by insulin pump, with twice-daily delivery. RESEARCH DESIGN AND METHODS: In a 6-month, open-label, randomized, crossover trial, PTH 1-34 was delivered by pump or twice-daily sc injection. After each 3-month study period, serum and 24-h urine mineral levels and bone turnover markers were measured daily for 3 d, and 24-h biochemical profiles were determined for serum minerals and 1,25-dihydroxyvitamin D(3) and for urine minerals and cAMP. STUDY PARTICIPANTS AND SETTING: Eight patients with postsurgical hypoparathyroidism (mean ± sd age 46 ± 5.6 yr) participated at a tertiary care referral center. RESULTS: Pump vs. twice-daily delivery of PTH 1-34 produced less fluctuation in serum calcium, a more than 50% reduction in urine calcium (P = 0.002), and a 65% reduction in the PTH dose to maintain eucalcemia (P < 0.001). Pump delivery also produced higher serum magnesium level (P = 0.02), normal urine magnesium, and reduced need for magnesium supplements. Finally, pump delivery normalized bone turnover markers and significantly lowered urinary cross-linked N-telopeptide of type 1 collagen and pyridinium crosslinks compared with twice-daily injections (P < 0.05). CONCLUSION: Pump delivery of PTH 1-34 provides the closest approach to date to physiological replacement therapy for hypoparathyroidism.
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Terapia de Reemplazo de Hormonas/métodos , Hipoparatiroidismo/tratamiento farmacológico , Hormona Paratiroidea/administración & dosificación , Adulto , Estudios Cruzados , Esquema de Medicación , Femenino , Humanos , Hipoparatiroidismo/sangre , Hipoparatiroidismo/etiología , Bombas de Infusión , Inyecciones Subcutáneas , Sistemas de Infusión de Insulina , Magnesio/sangre , Masculino , Persona de Mediana Edad , Hormona Paratiroidea/síntesis química , Fósforo/sangre , Complicaciones Posoperatorias/sangre , Complicaciones Posoperatorias/tratamiento farmacológico , Vitamina D/sangreRESUMEN
CONTEXT: Hypoparathyroidism is among the few hormonal insufficiency states not treated with replacement of the missing hormone. This is the first randomized controlled study in children comparing treatment with synthetic human PTH 1-34 and calcitriol. OBJECTIVE: The primary objective was to assess the efficacy and safety of long-term PTH 1-34 vs. calcitriol treatment in the maintenance of normal serum calcium values and renal calcium excretion in children with hypoparathyroidism. SETTING: The study was conducted at a clinical research center. SUBJECTS: Subjects included 12 children aged 5-14 yr with chronic hypoparathyroidism and without severe renal or hepatic insufficiency. STUDY DESIGN: The study was a 3-yr randomized parallel trial comparing twice-daily calcitriol (plus calcium and cholecalciferol in four daily doses) vs. s.c. PTH 1-34 treatment, with weekly or biweekly monitoring of serum and urine calcium. RESULTS: Mean predose serum calcium levels were maintained at, or just below, the normal range, and urine calcium levels remained in the normal range throughout the 3-yr study, with no significant differences between treatment groups. Creatinine clearance, corrected for body surface area, did not differ between groups and remained normal throughout the study. Markers of bone turnover were mildly elevated during PTH 1-34 therapy and remained within the normal range during calcitriol therapy. Mean bone mineral density Z-scores at the anterior-posterior lumbar spine, femoral neck, distal radius, and whole body remained within the normal range and did not differ between groups throughout the study. Similarly, height and weight percentiles did not differ between treatment groups and remained normal throughout the 3-yr follow-up. CONCLUSION: We conclude that PTH 1-34 therapy is safe and effective in maintaining stable calcium homeostasis in children with hypoparathyroidism. Additionally, PTH 1-34 treatment allowed normal skeletal development because there were no differences in bone mineral accrual, linear growth, or weight gain between the two treatment arms over the 3-yr study period.
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Calcitriol/uso terapéutico , Agonistas de los Canales de Calcio/uso terapéutico , Calcio/uso terapéutico , Hipoparatiroidismo/tratamiento farmacológico , Hormona Paratiroidea/uso terapéutico , Adolescente , Densidad Ósea/efectos de los fármacos , Calcitriol/efectos adversos , Calcio/efectos adversos , Calcio/sangre , Agonistas de los Canales de Calcio/efectos adversos , Niño , Preescolar , Enfermedad Crónica , Relación Dosis-Respuesta a Droga , Quimioterapia Combinada , Determinación de Punto Final , Femenino , Estudios de Seguimiento , Crecimiento/efectos de los fármacos , Terapia de Reemplazo de Hormonas , Humanos , Pruebas de Función Renal , Cuidados a Largo Plazo , Magnesio/sangre , Masculino , Hormona Paratiroidea/efectos adversos , Fósforo/sangre , Resultado del Tratamiento , Vitamina D/sangre , Aumento de Peso/efectos de los fármacosRESUMEN
CONTEXT: Hypoparathyroidism is among the few hormonal insufficiency states not treated with replacement of the missing hormone. Long-term conventional therapy with vitamin D and analogs may lead to nephrocalcinosis and renal insufficiency. OBJECTIVE: Our objective was to compare the response of once-daily vs. twice-daily PTH 1-34 treatment in children with hypoparathyroidism. SETTING: The study was conducted at a clinical research center. SUBJECTS: Fourteen children ages 4-17 yr with chronic hypoparathyroidism were studied. STUDY DESIGN: This was a randomized cross-over trial, lasting 28 wk, which compared two dose regimens, once-daily vs. twice-daily PTH1-34. Each 14-wk study arm was divided into a 2-wk inpatient dose-adjustment phase and a 12-wk outpatient phase. RESULTS: Mean predose serum calcium was maintained at levels just below the normal range. Repeated serum measures over a 24-h period showed that twice-daily PTH 1-34 increased serum calcium and magnesium levels more effectively than a once-daily dose. This was especially evident during the second half of the day (12-24 h). PTH 1-34 normalized mean 24-h urine calcium excretion on both treatment schedules. This was achieved with half the PTH 1-34 dose during the twice-daily regimen compared with the once-daily regimen (twice-daily, 25 +/-15 microg/d vs. once-daily, 58 +/- 28 microg/d; P < 0.001). CONCLUSIONS: We conclude that a twice-daily PTH 1-34 regimen provides a more effective treatment of hypoparathyroidism compared with once-daily treatment because it reduces the variation in serum calcium levels and accomplishes this at a lower total daily PTH 1-34 dose. The results showed, as in the previous study of adult patients with hypoparathyroidism, that a twice-daily regimen produced significantly improved metabolic control compared with once-daily PTH 1-34.
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Hipoparatiroidismo/tratamiento farmacológico , Teriparatido/administración & dosificación , Adolescente , Conservadores de la Densidad Ósea/administración & dosificación , Conservadores de la Densidad Ósea/efectos adversos , Calcio/sangre , Calcio/orina , Niño , Preescolar , Creatinina/orina , Estudios Cruzados , AMP Cíclico/orina , Esquema de Medicación , Femenino , Humanos , Hipoparatiroidismo/sangre , Hipoparatiroidismo/orina , Magnesio/sangre , Magnesio/orina , Masculino , Fósforo/sangre , Fósforo/orina , Teriparatido/efectos adversos , Factores de TiempoRESUMEN
This article presents a case study of how the evaluation design for a dating violence prevention and/or youth development program for American Indian youth in Arizona evolved throughout the project. Particular attention is given to how the evaluation design was guided by the tribal participatory research model. A brief rationale for the project is presented along with literature on culturally competent evaluation and research with American Indians. A description of the project and the unique communities in which it was implemented is provided. The focus of the article is the process of how the evaluation plan changed and how various factors influenced this process (e.g., feedback from community stakeholders, conversations with funder, results of process evaluation, suggestions from literature, the authors' experience working in American Indian communities). The authors conclude with lessons learned for others to consider as they develop working relationships and evaluation plans in similar communities.
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Investigación Participativa Basada en la Comunidad , Cortejo/etnología , Promoción de la Salud/organización & administración , Servicios de Salud del Indígena/organización & administración , Indígenas Norteamericanos/educación , Servicios de Salud Escolar/organización & administración , Violencia/etnología , Violencia/prevención & control , Adolescente , Arizona , Comunicación , Planificación en Salud Comunitaria/métodos , Cortejo/psicología , Cultura , Emociones , Humanos , Indígenas Norteamericanos/psicología , Relaciones Interpersonales , Negociación , Estudios de Casos Organizacionales , Proyectos Piloto , Evaluación de Programas y Proyectos de Salud , Universidades , Adulto JovenRESUMEN
If we wish to incorporate parents and community members as full partners in building character among youth, then the activities and programs in which youth participate during their out-of-school time are potentially important venues. This chapter describes how numerous agencies in a single community partnered with a university, with the help of the cooperative extension agent, to collect local data on how adolescents used out-of-school time, what they thought about right and wrong, and how well their own behavior comported with their understandings of what was right. Results indicated that surveyed youth characterized themselves as thinking more than acting in ethical ways. For instance, nearly half acknowledged having cheated on a test at least once in the past six months, although the vast majority thought that cheating was wrong. The three pathways the community identified for reaching youth were (1) extracurricular activities at school such as sports, yearbook, and pep club; (2) organized nonschool pursuits such as music, dance, hiking, and biking; and (3) religious activities. They found that nearly 90 percent of high school-aged respondents participated in one or another of these venues.
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Planificación en Salud Comunitaria , Relaciones Comunidad-Institución , Toma de Decisiones/ética , Actividades Recreativas , Desarrollo Moral , Psicología del Adolescente/ética , Estudiantes/psicología , Universidades , Adolescente , Carácter , Recolección de Datos , Femenino , Humanos , Masculino , Instituciones Académicas , Apoyo SocialRESUMEN
Hypoparathyroidism is one of the few remaining hormonal insufficiency states for which replacement therapy is unavailable. Previous short-term controlled trials have shown PTH to be a safe and effective treatment of hypoparathyroidism. In this randomized, parallel group, open-label trial, we compared synthetic human PTH-(1-34) (PTH) with conventional therapy, calcitriol and calcium, over a 3-yr period. Twenty-seven patients with confirmed hypoparathyroidism, aged 18-70 yr, were randomized to either twice daily sc PTH or oral calcitriol and calcium. The primary end points were calcium levels in serum and urine. Secondary end points were creatinine clearance, markers of bone turnover, and bone mineral density. Throughout the 3-yr study period, serum calcium levels were similar in both treatment groups within or just below the normal range. Mean urinary calcium excretion was within the normal range from 1-3 yr in PTH-treated patients, but remained above normal in the calcitriol group. Bone mineral content and bone mineral density showed no significant between-group differences over the 3-yr study period. We conclude that treatment with twice daily sc PTH provides a safe and effective alternative to calcitriol therapy and is able to maintain normal serum calcium levels without hypercalciuria for at least 3 yr in patients with hypoparathyroidism.
Asunto(s)
Calcitriol/uso terapéutico , Agonistas de los Canales de Calcio/uso terapéutico , Calcio/uso terapéutico , Hipoparatiroidismo/tratamiento farmacológico , Teriparatido/uso terapéutico , Adolescente , Adulto , Anciano , Fosfatasa Alcalina/metabolismo , Aminoácidos/orina , Densidad Ósea/efectos de los fármacos , Huesos/efectos de los fármacos , Huesos/metabolismo , Calcio/sangre , Calcio/orina , Creatinina/metabolismo , Femenino , Humanos , Hipoparatiroidismo/complicaciones , Magnesio/sangre , Magnesio/orina , Masculino , Persona de Mediana Edad , Nefrocalcinosis/diagnóstico por imagen , Nefrocalcinosis/etiología , Fósforo/orina , Radiografía , Resultado del TratamientoRESUMEN
PURPOSE: To examine risk and resilience factors at multiple ecological levels related to Zimbabwean adolescents' practice of protected or unprotected sex. METHODS: Data were collected from adolescents in eight secondary schools in Zimbabwe. A 140-item instrument designed by the authors assessed adolescent perceptions, behaviors, and attitudes. Youth who had engaged in sexual intercourse (n = 730) were included in analyses. Risk and resilience factors related to self, peer, family, and community domains were examined. Data were analyzed separately by gender using discriminant analysis to identify factors that predict whether youth engage in safe or unsafe sex. RESULTS: Boys who engaged in safe sex were older, more likely to report their parents were there when needed, spent more time in extracurricular activities, and reported a lower drop out likelihood. Girls who engaged in safe sex worried about HIV/AIDS more than those who engaged in unsafe sex. CONCLUSIONS: Although both boys and girls need medically correct sexuality education, including education on HIV/AIDS and sexually transmitted diseases (STDs), the findings suggest that such education is not enough. Program planners must consider the influences of multiple ecological levels. Gender differences raise several issues for intervention.