Recurrence of intramucosal esophageal adenocarcinoma arising in a former esophagostomy site: a unique case report.

A 75-year-old male with a long history of gastroesophageal reflux symptoms developed adenocarcinoma proximally within a long segment of Barrett's esophagus. He was taken for esophagectomy and gastric pull-up, but intraoperatively, he was found to have a marginal blood supply in the gastric tube. A temporary left-sided esophagostomy was created with the gastric tube sutured to the left sternocleidomastoid muscle in the neck. Pathology showed an intramucosal adenocarcinoma, limited to the muscularis mucosa with surrounding high-grade dysplasia and intestinal metaplasia. The proximal esophageal margin showed no tumor cells, but there was low-grade dysplasia within Barrett's esophagus. He was reconstructed after several months, and 2 years after reconstruction, the patient noticed a nodule at the former esophagostomy site. Biopsy revealed an implant metastasis of esophageal adenocarcinoma. Here, we review the literature and discuss the possible etiology.

En bloc esophagectomy reduces local recurrence and improves survival compared with transhiatal resection after neoadjuvant therapy for esophageal adenocarcinoma.

OBJECTIVE: Neoadjuvant therapy is commonly used for esophageal adenocarcinoma. We have reported reduced local recurrence rates and improved survival after an en bloc esophagectomy compared with a transhiatal resection as primary therapy for adenocarcinoma of the esophagus. The aim of this study was to determine whether the benefits of an en bloc resection would extend to patients after neoadjuvant therapy. METHODS: The charts of all patients with esophageal adenocarcinoma that had neoadjuvant therapy and en bloc or transhiatal esophagectomy from 1992-2005 were reviewed. Patients found to have systemic metastatic disease at the time of the operation or who had an incomplete resection were excluded. RESULTS: There were 58 patients: 40 had an en bloc resection and 18 had a transhiatal esophagectomy. A complete pathologic response occurred in 17 (29.3%) of 58 patients. Median follow-up was 34.1 months after en bloc resection and 18.3 months after transhiatal resection (P = .18). Overall survival at 5 years and survival in patients with residual disease after neoadjuvant therapy was significantly better with an en bloc resection (overall survival: 51% for en bloc resection and 22% for transhiatal resection [P = .04]; survival with residual disease: 48% for en bloc resection and 9% for transhiatal resection [P = .02]). Survival in patients with complete pathologic response tended to be better after an en bloc resection (en bloc, 70%; transhiatal, 43%; P = .3). CONCLUSION: An en bloc resection provides a survival advantage to patients after neoadjuvant therapy compared with a transhiatal resection, particularly for those with residual disease. Similar to patients treated with primary resection, an en bloc esophagectomy is the procedure of choice after neoadjuvant therapy.

[Comparison of high-order optical aberrations induced by different multifocal contact lens geometries]. / Comparaison des aberrations optiques oculaires d'ordre élevé induites par différentes géométries de lentilles multifocales.

PURPOSE: To analyze the effects of different multifocal soft contact lens geometries on high-order ocular optical aberrations. MATERIALS AND METHODS: Thirty nonpresbyopic eyes were fitted with eight multifocal contact lenses: Soflens Multifocal High, Soflens Multifocal Low, Focus progressive, Acuvue Bifocal Add +2.00, Rythmic Multifocal Profile 1, Rythmic Multifocal Profile 2, Proclear D Add 2.00, Proclear N Add 2.00. All these contact lenses corrected the ametropia for far distance. The ocular aberrations were measured with and without each contact lens using a Hartmann-Shack aberrometer, (Zywave from Bausch and Lomb) successively after pupil dilation with one or two drops of Neo-Synephrine and wavefront decomposition in Zernike polynomials up to the 5th order. RESULTS: Odd and even aberrations increased for all the tested multifocal soft contact lenses. The most significant increase was noted for the a(4.0) Zernike coefficient. The mean value of a(4.0) without contact lens was -0.178+/-0.121 microm. The contact lenses having a central zone for near addition cause the inversion of the sign of the a(40) coefficient The central far vision contact lens leads to the opposite effect, increasing spherical positive aberrations. The most significant increase in total high-order ocular aberrations were noted for Proclear D soft contact lenses (0.396+/-0.109 microm without contact lens, 0.511+/-0.123 microm with contact lens; p<0.05, +29%), for Proclear N soft contact lenses (0.396+/-0.109 microm without contact lens, 0.568+/-0.165 microm with contact lens; p<0.05 +43%) and for Acuvue Bifocal soft contact lens (0.396+/-0.109 microm without contact lens, 0.567+/-0.162 microm with contact lens; p<0.05 +43%). CONCLUSION: Wearing multifocal contact lenses induces an increase in high-order ocular aberrations. The location of the near addition zone is related to the sign of the variation of the a(4.0) coefficient. The central near vision multifocal contact lenses seem to induce large amounts of negative spherical aberrations. The far vision contact lenses seem to induce an increase in positive spherical aberrations. The relative decentration of the lens to the pupil may explain the increase in odd high-order aberrations. These results might be useful to understand the visual complaints of patients fitted with multifocal contact lenses.

Live-donor liver transplantation: the USC experience.

BACKGROUND: Liver transplantation is currently the standard of care for patients with end stage liver disease. However due to the cadaveric organ shortage, live donor liver transplantation (LDLT), has been recently introduced as a potential solution. We analyzed and support our initial experience with this procedure at USC. MATERIAL AND METHODS: From September 1998 until July 2000, a total of 27 patients underwent LDLT at USC University Hospital and Los Angeles Children's Hospital. There were 12 children with the median age of 10 months (4-114) and 15 adults with the median age of 56 years (35-65). The most common indication for transplantation was biliary atresia for children and hepatitis C for adults. RESULTS: All donors did well postoperatively; the median postoperative stay was five days (5-7) for left lateral segmentectomy and seven days (4-12) for lobar donation. None of the donors required blood transfusion, re-operation or postoperative invasive procedure. However, five of them (18%) experienced minor complications. The survival rate in pediatric patients was 100% and only one graft was lost at nine months due to rejection. Two adult recipients died in the postoperative period, one from graft non-function and one from necrotizing fascitis. 37% of adult recipients experienced postoperative complications, mainly related to biliary reconstruction. Also 26% of the recipients underwent reoperation for some of these complications. CONCLUSION: LDLT is an excellent alternative to cadaveric transplantation with excellent results in the pediatric population. However, in adult patients it still carries a significant complication rate and it should be used with caution.

Sexual attitudes and behavior of Guatemalan teenagers: considerations for prevention of adolescent pregnancy.

Two studies were conducted to explore the prevalence of adolescent pregnancy in Guatemala, and to identify the level of contraception. The first study assessed sexual attitudes and behavior of 850 adolescents. In this group, 89% of the males and 38% of the females said they had experienced coitus. Youngsters of upper-middle and lower-middle socioeconomic status had higher rates of coital activity than did those of the middle class. Only 10% of the sexually active couples were using some type of contraception. Boys indicated greater inclination toward "recreational" sex, while girls tended to be more affectively involved with their lovers. Ninety-six percent of sexually active girls planned to marry their current sexual partner, while 5.5% of the boys planned to do so. The second study assessed the prevalence of pregnancy in minors (17 years or younger) attending the gynecology department at a local general hospital. Over a period of two years, 551 cases were identified. Although rates of pregnancy increased with age, the rate of annual increase was dramatically highest from ages 13 to 14, after which it decreased progressively with age. Based on these results, it is recommended that, at least in the Guatemalan population, sex education be implemented at an early age in order to prevent adolescent pregnancy.

PIP: Two studies were conducted to explore the prevalence of adolescent pregnancy in Guatemala, and to identify the level of contraception. The 1st study assessed sexual attitudes and behavior of 850 adolescents. In this group, 89% of the males and 38% of the females said they had experienced coitus. Youngsters of upper-middle and lower-middle socioeconomic status and higher rates of coital activity than did those of the middle class. Only 10% of the sexually active couples were using some type of contraception. Boys indicated greater inclination toward "recreational" sex, while girls tended to be more affectively involved with their lovers. 96% of sexually active girls planned to marry their current sexual partner, while 5.5% of the boys planned to do so. The 2nd study assessed the prevalence of pregnancy in minors (17 years or younger) attending the gynecology department at a local general hospital. Over a period of 2 years, 551 cases were identified. Although rates of pregnancy increased with age, the rate of annual increase was dramatically highest from ages 13 to 14, after which it decreased progressively with age. Based on these results, it is recommended that, at least in the Guatemalan population, sex education be implemented at an early age in order to prevent adolescent pregnancy.

[A new concept of dressing: silastic foam]. / Une conception nouvelle du pansement "la mousse silastic".

The authors report their experience, still short, of a new type of dressing based upon Silastic foam used in general surgery. They emphasise the considerable progress achieved in the everyday care of their patients with easy to manage dressings and the virtual disappearance of pain. This has transformed the patients' existence and has made early physiotherapy possible in certain of them. The simplicity of use of this dressing leads to savings in time and cost and if the patient is cooperative the possibility of widespread use at home by the patient himself. The properties of this foam form the basis for a wide range of indications going beyond general surgery, with applications in ENT, dermatology, rehabilitation centres, etc. Results are satisfactory in 90% of cases, the only failures being due to a failure to obey the basic principles of care: doubtful indication (inadequate disinfection of wounds), neglect of concomitant pathology (diabetes, nutritional state) or lack of patient cooperation.