Outcomes-based trial of an inpatient nurse practitioner service for general medical patients.

Although teaching hospitals are increasingly using nurse practitioners (NPs) to provide inpatient care, few studies have compared care delivered by NPs and housestaff or the ability of NPs to admit and manage unselected general medical patients. In a Midwest academic teaching hospital 381 patients were randomized to general medical wards staffed either by NPs and a medical director or medical housestaff. Data were obtained from medical records, interviews and hospital databases. Outcomes were compared on both an intention to treat (i.e. wards to which patients were randomized) and actual treatment (i.e. wards to which patients were admitted) basis. At admission, patients assigned randomly to NP-based care (n = 193) and housestaff care (n= 188) were similar with respect to demographics, comorbidity, severity of illness and functional parameters. Outcomes at discharge and at 6 weeks after discharge were similar (P>0.10) in the two groups, including: length of stay; charges; costs; consultations; complications; transfers to intensive care; 30-day mortality; patient assessments of care; and changes in activities of daily living, SF-36 scores and symptom severity. However, after randomization, 90 of 193 patients (47%) assigned to the NP ward were actually admitted to housestaff wards, largely because of attending physicians and NP requests. None the less, outcomes of patients admitted to NP and housestaff wards were similar (P>0.1). NP-based care can be implemented successfully in teaching hospitals and, compared to housestaff care, may be associated with similar costs and clinical and functional outcomes. However, there may be important obstacles to increasing the number of patients cared for by NPs, including physician concerns about NPs' capabilities and NPs' limited flexibility in managing varying numbers of patients and accepting off-hours admissions.

Septic arthritis.

Septic arthritis is a medical emergency that can lead to significant morbidity and mortality. Prompt recognition and treatment are critical to ensuring a good prognosis. Thus, this article reviews the clinical presentation, microbiology, diagnostic workup, and outcome of nonprosthetic joint infections.

Update on measurement of relevant outcomes in rheumatology.

It is now recognized that disease has a multidimensional impact on patients' lives. This impact can be perceived as a spectrum encompassing on one end "hard" disease outcomes such as organ failure and mortality, and on the other end "soft" outcomes such as quality of life or patient satisfaction. This spectrum may be viewed as a framework in measuring both disease impact and response to treatment. In this paper, we review improvements in the methodology of measurement of relevant outcomes and highlight new findings and emerging trends in rheumatology.

Treatment of refractory psoriatic arthritis.

Psoriatic arthritis occurs in approximately 5% of patients with psoriasis and can lead to significant morbidity. Treatment options for refractory psoriatic arthritis can be divided into (1) medications used in the treatment of other rheumatic diseases and (2) experimental agents. This article reviews available therapeutic agents for psoriatic arthritis and outlines an approach to treatment. The use of physiotherapy and surgery and the management of arthritis mutilans are also reviewed.

Sexual and physical abuse in women with fibromyalgia syndrome.

OBJECTIVE: To determine the prevalence of sexual and physical abuse in female patients with fibromyalgia syndrome (FMS), as compared with rheumatic disease control patients. METHODS: Eighty-three female FMS patients and 161 consecutive female rheumatology (non-FMS) control patients answered a standardized confidential questionnaire recording previous sexual and physical abuse, drug and alcohol abuse, and eating disorders. Demographic information was collected on age, education, economic status, and cultural group. RESULTS: Overall abuse was greater in FMS patients than in control patients (53% versus 42%; P not significant). Significant differences were observed for lifetime sexual abuse (17% versus 6%), physical abuse (18% versus 4%), combined physical and sexual abuse (17% versus 5%), and drug abuse (16% versus 3%). There was a trend toward a higher incidence of childhood sexual abuse (37% versus 22%) and of eating disorders (10% versus 3%) in the FMS patient group. CONCLUSION: A high frequency of sexual abuse was identified both in control patients and in FMS patients. A statistical association was demonstrated between FMS and the frequency and severity of sexual abuse, and the frequency of physical abuse and drug abuse. These results raise the possibility that abuse may have an effect upon the expression and perpetuation of FMS in adult life.