[Lipid peroxidation and the role of quaternary ammonium compounds in normalizing this process]. / Perekisnoe okislenie lipidov i rol' nekotorykh chetvertichnykh ammonievykh soedinenii v normalizatsii étogo protsessa.

Regulation of lipid peroxidation is realized not only by antioxidant enzymes but by natural antioxidants as well. We have lately succeeded, together with the students, in identifying antioxidant properties of quaternary ammonium compounds, which fact makes it possible for the above properties to gain extensive applicability in a setting where there is this variety of disbolism. One of such drug preparations is ethonium. The article contains information about uses of ethonium in the tablet dose form. The tablets are of little toxicity, they stimulate the oxidation-reduction processes and proved to be effective in experimental gastric and duodenal ulcers.

[The antioxidant activity of bis-quaternary ammonium compounds of the methylene series]. / Antioksidantnaia aktivnost' bischetvertichnykh ammonievykh soedinenii metilenovogo riada.

Experiments on albino rats were made to reveal antioxidant activity of bisquaternary ammonium compounds of the methylene series (ethonium, thionium and dodeconium). It is determined by the enhancement of superoxide anion radicals neutralization and splitting of lipoperoxides.

[The antistaphylococcal activity of thionium in in vitro experiments]. / Izuchenie antistafilokokkovoi aktivnosti tioniia v opytakh in vitro.

The paper deals with the experimental study of antistaphylococcal properties of thionium--a derivative of bis-quarternary ammonium compounds. High bactericide activity of the preparation is revealed as a result; it is preserved under high contents of protein substances in the media. The sensitivity of staphylococcal strains to thionium is not affected by the initial sensitivity of microorganisms to antibiotics. The preparations interaction with benzylpenicillin and gentamycin has been studied. Synergist effect of sub-bacteriostatic doses of thionium with the mentioned antibiotics has been found. Effect of benzylpenicillin increases 4-32 times, that of gentamycin--64-512 times independent of the primary sensitivity to these antibiotics. The further study of a new antistaphylococcal preparation is advisable.

[Combined effect of ethonium and antibiotics on Pseudomonas aeruginosa]. / Kombinirovannoe deistvie étoniia s antibiotikami na Pseudomonas aeruginosa.

The combined effect of ethonium and 5 antibiotics belonging to different groups was studied with 30 clinical strains of P. aeruginosa. A 2--8-fold increase in the activity of kanamycin and tetracycline against some strains was observed. The MIC of carbenicillin, polymycin M and cefotaxime was lowered by 2--6 times and with respect to some strains by 16--32 times. The detergent is recommended to be used in combination with some antibiotics in treatment of infections caused by resistant strains of P. aeruginosa.