RESUMEN
Measurements of concentrations of Marburg virus in guinea pig saliva, urine, and feces showed that as early as by the end of incubation period the virus concentrations in the feces and saliva were 2.3-3.3 lg LD50. In the blood the content of the virus was high and increased by the end of the disease, while the concentrations in the urine, saliva, and feces were virtually the same throughout the disease.
Asunto(s)
Enfermedad del Virus de Marburg/virología , Marburgvirus/aislamiento & purificación , Animales , Heces/virología , Cobayas , Dosificación Letal Mediana , Enfermedad del Virus de Marburg/sangre , Saliva/virología , Orina/virología , ViremiaRESUMEN
Changes in some parameters of hemostasis in rabbits insusceptible to Ebola virus (EV) in various periods after reinoculations with live and inactivated virus are described. Challenge with both control protein and live and inactivated EV leads to imbalance in the hemostasis system, which is compensated for in the course of follow-up and does not result in clinically manifest disorders of blood clotting. However, the mechanisms of development of the hemostasis imbalance caused by the control protein and virus preparations were different. In the former case no fibrinogen degradation products were detected in the blood serum, whereas in the latter they appeared in the serum after each reinoculation of the virus. This indicates a peculiar effect of EV on hemostasis.