RESUMEN
Secondary oocytes from mice receiving vincristine in amounts corresponding to therapeutic doses in human, in neoplasm treatment, were evaluated morphometrically and ultrastructurally. In the group of animals treated with vincristine an increase of the volume fraction of vesicular complexes and a decrease of the volume fraction of fibrous material were observed. It has also been demonstrated that, in secondary oocytes from mice receiving vincristine, the number of both multivesicular bodies and vesicles falling to one vesicular complex profile was higher than in the control group. The present results suggest that vincristine applied to females, even in therapeutic doses, may affect egg cells.
Asunto(s)
Oocitos/efectos de los fármacos , Vincristina/toxicidad , Animales , Femenino , Ratones , Oocitos/ultraestructuraRESUMEN
This paper describes a reconstruction of both hands after amputations because of severe frostbite. The right hand was reconstructed in two stages by free second toe and double toe transfer. A one-stage free transfer of the third, fourth and fifth toes was used for reconstruction of the left hand.
Asunto(s)
Amputación Quirúrgica/rehabilitación , Dedos/cirugía , Congelación de Extremidades/cirugía , Dedos del Pie/trasplante , Adulto , Humanos , Masculino , Pulgar/cirugíaRESUMEN
We have achieved favorable results in reconstruction of the palmar surface of the thumb using the neurovascular flap from the index. The technique was applied in several patients with defects of the palmar surface and the tip of the thumb. Satisfactory functional and aesthetic results were obtained. It seems to be a very useful method to restore the sensory area of the thumb.
