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Tuberculosis (Edinb) ; 134: 102205, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-35405568

RESUMEN

Since distinguishing pulmonary (PTB) from latent tuberculosis (LTBI) in pediatric patients remains a challenge, we aimed to investigate the efficacy of immune mediators in diagnosing PTB and LTBI in this population. In this cross-sectional study performed with children and adolescents, serum levels of 20 biomarkers were assessed and data were analyzed according to age groups. We included 65 participants (PTB, n = 28 and LTBI, n = 37). Overall, levels of TNF-α, IL-1Ra, IL-6, IL-17A, VEGF, MMP-1, and procalcitonin were significantly higher (P < 0.05) in adolescents and children <10 years-old with PTB. Also, principal component analysis (PCA) showed that immune mediators were able to distinguish PTB from LTBI. VEGF and IL-1Ra presented the highest area under the curve (AUC) values, both separately (AUC 0.890 and 0.785) and combined (AUC 0.99). Taken together, we showed that VEGF and IL-1Ra are promising biomarkers to distinguish PTB from LTBI in pediatric patients, especially in children <5 years-old.


Asunto(s)
Tuberculosis Latente , Mycobacterium tuberculosis , Adolescente , Biomarcadores , Niño , Preescolar , Estudios Transversales , Humanos , Proteína Antagonista del Receptor de Interleucina 1 , Receptores de Interleucina-1 , Factor A de Crecimiento Endotelial Vascular , Factores de Crecimiento Endotelial Vascular
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