RESUMEN
In December 2019, a novel coronavirus known as SARS-CoV-2 was first detected in Wuhan, China, causing outbreaks of the coronavirus disease COVID-19 that has now spread globally. For this reason, The World Health Organization (WHO) declared COVID-19 a public health emergency in March 2020. People living with pre-existing conditions such as obesity, cardiovascular diseases, type 2 diabetes (T2D), and chronic kidney and lung diseases, are prone to develop severe forms of disease with fatal outcomes. Metabolic diseases such as obesity and T2D alter the balance of innate and adaptive responses. Both diseases share common features characterized by augmented adiposity associated with a chronic systemic low-grade inflammation, senescence, immunoglobulin glycation, and abnormalities in the number and function of adaptive immune cells. In obese and T2D patients infected by SARS-CoV-2, where immune cells are already hampered, this response appears to be stronger. In this review, we describe the abnormalities of the immune system, and summarize clinical findings of COVID-19 patients with pre-existing conditions such as obesity and T2D as this group is at greater risk of suffering severe and fatal clinical outcomes.
RESUMEN
La enfermedad de Still del Adulto (ESA) y su comportamiento sistémico, determina que el clínico la incluya en el diagnóstico diferencial, una vez que patologías tóxicas y febriles con grandes similitudes son evaluadas en forma cotidiana, evitando así una interpretación errónea de los hallazgos clínicos-complementarios y el deterioro funcional osteoarticular de los portadores tras su detención oportuna. Se da entonces a conocer tres casos clínicos de ESA, revisando la literatura sobre tópicos de interés como la utilidad de la ferritina en el diagnóstico de la entidad y aportando una característica compartida por dos de las observaciones en el esqueleto axial, espina bífida, no encontrada en las revisiones realizadas.
Asunto(s)
Disrafia Espinal , Enfermedad de Still del Adulto , Ferritinas , Departamentos de Hospitales , Hospitales de Enseñanza , Medicina InternaRESUMEN
La dermatomiositis es una enfermedad autoinmune caracterizada por debilidad muscular proximal, aumento de enzimas musculares y afección cutánea. Se presenta el caso clínico de una mujer de 35 años con historia de ocho meses de evolución caracterizada por compromiso tegumentario sin alteración muscular.