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1.
Radiats Biol Radioecol ; 34(1): 138-42, 1994.
Artículo en Ruso | MEDLINE | ID: mdl-8148969

RESUMEN

CM-5 fraction of tortoise spleen extract injected after irradiation in dose CD50/30 (540 R) raises a survival of mice to 73.4%. The number of endocolonies of spleen increases to 4.0 in experiment against 0.3 in control and the average life of experimental animals increases to 12.7 days against 8.8 in control. In vitro it has been found a considerable increase of RNA-synthetic activity of bone marrow cells stimulated by CM-5 fraction in post-irradiation period. The dose alteration factor for CM-5 fraction is 1.46 according to CD50/30 standard at survival test.


Asunto(s)
Traumatismos Experimentales por Radiación/tratamiento farmacológico , Protectores contra Radiación/uso terapéutico , Bazo , Extractos de Tejidos/uso terapéutico , Tortugas , Animales , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Femenino , Masculino , Ratones , Traumatismos Experimentales por Radiación/mortalidad , Factores de Tiempo , Irradiación Corporal Total
3.
Gig Sanit ; (6): 15-7, 1991 Jun.
Artículo en Ruso | MEDLINE | ID: mdl-1769568

RESUMEN

In the experiments with white rats it was found, that the inhalation of freon 114B2 at CL16, CL50, CL84 levels caused the changes in seasonal values of the energy activity in mitochondria. The action of the freon 114B2 caused disturbances in regulation of the mitochondria activity and desynchronization of seasonal rhythms of their energy activity.


Asunto(s)
Clorofluorocarburos de Metano/toxicidad , Metabolismo Energético/efectos de los fármacos , Mitocondrias Hepáticas/efectos de los fármacos , Estaciones del Año , Animales , Bromoclorofluorocarbonos , Humanos , Masculino , Mitocondrias Hepáticas/enzimología , Ratas
4.
Radiobiologiia ; 30(5): 699-701, 1990.
Artículo en Ruso | MEDLINE | ID: mdl-2251363

RESUMEN

The implantation of a bone marrow fragment of intact mouse donors below the kidney capsule of irradiated (7 Gy) recipients leads to the formation of the haemopoiesis locus that somewhat exceeds, by mass and cellularity, the new-formed locus of control animals. The U-2 fraction of a tortoise spleen extract administered to recipients irradiated with the same dose increases the mass and cellularity of the haemopoiesis locus by 2.2 and 4.9 times respectively.


Asunto(s)
Hematopoyesis Extramedular/efectos de los fármacos , Traumatismos Experimentales por Radiación/fisiopatología , Bazo/fisiología , Extractos de Tejidos/uso terapéutico , Tortugas , Animales , Femenino , Masculino , Ratones , Estimulación Química
6.
Tissue Cell ; 22(3): 385-7, 1990.
Artículo en Inglés | MEDLINE | ID: mdl-18620309

RESUMEN

The micromorphology and surface topography of spleen cells of the Middle Asian tortoise, Testudo horsfieldi, have been examined by scanning electron microscopy. Spleen cells comprise a population with surface characteristics similar to counterparts in mammalian spleen except for an, as yet undescribed, lymphocyte which is designated as lamellar type on the basis of its surface contours.

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