Antioxidants in bovine colostrum.

Quality, content and properties of colostrum are crucial for the neonate and its further development. Due to essential differences between intrauterine and extrauterine environment, the neonate is exposed to oxidative stress conditions. Colostrum apart from nutrient and immunological components should contain antioxidative systems necessary for the protection against reactive oxygen species. This review describes available data on enzymatic and non-enzymatic antioxidants in colostrum. Due to the fact that the literature concerning bovine colostrum is scanty, the information based on bovine mature milk determinations as well as other species is provided. Bovine colostrum is used not only by calves, but also for the production of hyperimmunized colostrum, medicines or feed supplements. Quality of colostrum influences quality of mature milk. This is another reason, except from health of neonate, why antioxidative properties of bovine colostrum are of special importance and require further detailed elucidation.

Electrophoretic seed globulin patterns and species relationships in the genus Lens Miller.

SDS-PAGE analysis of seed globulins covered 200 accessions of the following Lens taxa: L. culinaris subsp. culinaris, L. culinaris subsp. orientalis, L. odemensis, L. ervoides, L. nigricans, L. lamottei and L. tomentosus. The number of polypeptide bands detected in particular taxa varied from 22 in L. lamottei to 35 in L. ervoides. All the taxa under study showed variation due to differences among accessions and individual variation. Electrophoretic data were subjected to statistical analysis by the UPGMA method based on Euclidean distances. In the case of L. culinaris subsp. culinaris, some distinctness of the microsperma accessions from southern and central Asia was found. As to relationships among the studied taxa, the obtained results showed that L. culinaris subsp. culinaris appeared to be most closely allied to L. odemensis, while L. culinaris subsp. orientalis was found to be the closest relative of L. tomentosus. The four taxa formed one cluster separated from L. lamottei and L. ervoides. L. nigricans was shown to be the most divergent taxon.

[Aerosolotherapy as one of the supporting methods of treatment of patients with head and neck tumors]. / Aerozoloterapia jako jedna z metod wspomagajacych leczenie chorych z choroba nowotworowa w obrebie glowy i szyi.

In our paper distinctive features of aerosol-drugs and the types of inhalers are presented. The authors indicate the possibility of aerosolotherapy as one of the supporting methods of treatment of patients with head and neck tumors: pracancerous states of the larynx (pachydermy, leucoplaky); states after laser CO2--surgery of tumour T1 of the larynx; states after surgical treatment widening true glottis narrowed by the paresis of nerve recur caused the tumour of thyroid gland or neighbouring structures; states after total laryngectomy; states in the course of or after complementary radiotherapy after surgical treatment head and neck tumour. On the basis of studied cases, which were treated with aerosol-drugs in Aerosolotherapy Unit, Department of Otolaryngology Karol Marcinkowski University of Medical Sciences in Poznan (Poland) in 1992-1998 years usefulness of this method in the states mentioned has been proved.

[Primary neoplasms of the parapharyngeal space in material from the Otolaryngology Department, Karol Marcinkowski University of Medical Sciences in Poznan]. / Pierwotne nowotwory przestrzeni przygardlowej w materiale Kliniki Otolaryngologii AM im. K. Marcinkowskiego w Poznaniu w latach 1993-1998.

Primary neoplasms of parapharyngeal space are rare. In this location the so called non-malignant tumors occur many times more than the malignant ones. In our paper, employing statistics, objective symptoms and complaints connected with these tumors were ordered according to frequency. In recent five years in ENT Department of Karol Marcinkowski University of Medical Sciences in Poznan 9 persons were surgically treated. The differentiated histopathological picture is discussed and described (6 malignant and 3 non-malignant). It can be claimed that MR is more useful in diagnosis than CT. The treatment is usually surgical; both external and oral approaches are used.

[Otitis media in patients with Down's syndrome]. / Zapalenie ucha srodkowego u chorych z zespolem Downa.

61 patients with Down's syndrome were examined. Otitis media was diagnosed in 19 patients. Conductive hearing impairment after otitis media was observed in pure tone audiometry and speech audiometry. It was emphasized that conductive hearing loss in children with Down's syndrome is a very important factor in retarded speech development. Children with recurrent otitis media were treated by surgery (9 adenotomies) and conservative treatment such as insufflation and catheterisation of Eustachian tubes, pharmacotherapy. Treatment of otitis media was difficult because of anatomical anomalies of facialocranium, atrophic mucous membrane of upper respiratory tract, reduced immunity.

[Use of mucolytic preparations (Mucosolvan) in selected diseases of the upper respiratory tract. Part II]. / Zastosowanie preparatów mukolitycznych (Mucosolvan) w wybranych schorzeniach górnych dróg oddechowych. Czesc II.

The majority of publications in the recent years emphasizes the importance of mucolytic preparations in the upper respiratory tract diseases. There have been very few report about the important role which mucolytic drugs may play in the diseases of the upper respiratory tract. This paper undertakes the task of attempting to evaluate the usefulness of Mucosolvan preparation in laryngological diseases. The main condition of the successful treatment of otolaryngological diseases is maintaining the efficient mechanism of the clearing of upper respiratory tract. This is achieved by means of the mucocilia apparatus, namely cilia and mucosa protecting the epithelium from harmful factors. Tests were carried out on 60 patients with paranasal sinuses and ear diseases. The first group comprised 45 patients who were qualified on the basis of inflammatory changes in paranasal sinuses. The second group comprised 12 children and 3 adults with otitis media with effusion. Mucosolvan which was used in the supplementary treatment fulfilled our expectations. The use of the mucolytic drug accelerated the healing process, proper regeneration of the epithelium and the reduction of the period of drug administration.

[A rare case of carcinoma cuniculatum within the nasal cavity and paranasal sinuses]. / Rzadki przypadek carcinoma cuniculatum jamy nosowej i zatok obocznych nosa.

A rare case of carcinoma cuniculatum of the nasal cavity et paranasales sinuses is presented. This tumor is mature planoepithelial carcinoma, difficult to diagnose even by experienced histopathologists. It is characterized by very slow growth and local malignancy, develops it damages cartilages and bones.

[The use of mucolytic preparations (Mucosolvan) in nasal and paranasal sinuses in children]. / Zastosowanie leków mukolitycznych (Mucosolvan) w stanach zapalnych zatok przynosowych u dzieci.

In recent years there has been observed an increase in the infections of nose cavity and paranasal sinuses. This phenomenon is connected with a multidirectional alergization of the environment also with the insufficiency of conservative and surgical treatment. Messerklinger's research concerning cilial movements of mucosa in nasal and paranasal sinuses together with his endoscopic experiments are the basic for modern therapy of nasal and paranasal sinuses. In this paper 40 cases of acute and chronic inflammation of paranasal sinuses in children between 3 and 16 years of age were presented. In all cases regardless of the used method of conservative or surgical treatment children were given mucolytic preparations in the form of Mucosolvan by Boehringer Ingelheim. In all observed cases we noticed the shortening of the normal period of the antiinflammatory antibiotic treatment. A part from that, mucolitic preparations due to the decrease of mucous adhesiveness to the walls of paranasal sinuses allow for its evacuation largely decreasing the pain. After FESS treatment, the administration mucolytic preparations causes a factor regeneration of cilial epithelium, proper functioning of cilia and the speeding of mucocilial trnasport, which makes the recovery of an ill child much quicker.

[CT examination of the temporal bones for cochlear implantation]. / Badanie CT kosci skroniowych u osób przygotowanych do operacji wszczepu slimakowego.

CT examinations of temporal bones were performed in 31 deaf patients from qualify diagnostic stage prepared for cochlear implants. Essential for surgical treatment anatomic details were estimated, especially canalis spiralis cochleae was paid to attention. In our group, 8 patients had some CT changes (abnormal findings) which corresponded to different stages of obliteration the cochlea. The majority of patients lost the hearing because of meningitis. In 6 implanted patients CT scan was compared with surgical findings. During the operation 1 patient with patent cochlea on CT scan had partially ossified basal turn.

[Hearing impairment in children with Down's syndrome]. / Zaburzenia sluchu u dzieci z zespolem Downa.

The purpose of this study was the examination of 60 children with Down's syndrome with particular attention paid to the organ of hearing. The investigation included anamnesis concerning the risk factors of hearing loss, psychomotoric development, otolaryngological examination, pure tone, impedance and speech audiometry. The main conclusion is: hearing impairment is more frequent in children with Down's syndrome (82.8%) than in normal population (0.5-2%). The type of hearing impairment is mainly conductive and mild degree.

[The Poznan program of the treatment of deafness by multichannel cochlear implants]. / Poznanski program leczenia gluchoty przy uzyciu wielokanalowego wszczepu slimakowego.

The authors presented 5 deaf patients with postlingual deafness and application of cochlear implant "Nucleus Mini System 22". In details operative technics and postoperative proceeding were described as well as rehabilitation results in 3-6 months after operation. The authors consider, that in adults with postlingual deafness, application of cochlear implants were giving very good effects.

[The first experience in diagnosis and rehabiliation in patients with cochlear implant "Nuclear Mini System 22"]. / Pierwsze doswiadczenia diagnostyczne i rehabilitacyjne u chorych przed i po zalozeniu wszczepu slimakowego "nucleus mini system 22".

The first qualification for cochlear implant "Nucleus" was performed on the basis of audiological tests. Next stage was conversation with a patient and his family about motivation of longterm rehabilitation. Then the two very important investigations were carried out--the computer tomography which showed inner ear structure, and electric promotory test. In rehabilitation process original "Nucleus" partially modified and Polish linguistic articulation lists were used.

Isoprinosine in the early pre-erosive stage of rheumatoid arthritis: a pilot study.

The etiology of rheumatoid arthritis is unknown. Virus infection is one of alleged factors initiating the disease process. In view of this, the authors undertook a trial of administration of an antiviral and immunostimulating preparation - isoprinosine, given in the early phase of the disease prior to the development of erosions. Isoprinosine was given to ten seropositive cases of rheumatoid arthritis (two males, eight females) aged 34-61 years, with disease duration from 6 months to 5 years treated previously only with non-steroidal anti-inflammatory drugs. Isoprinosine was administered for 4 weeks (2 weeks of 3.0 g daily and 2 weeks of 1.5 g daily). After the treatment, a statistically significant reduction was observed in the number of joints painful on pressure, the number of swollen joints, and the duration of morning stiffness. The grip strength of the left hand was increased. The ESR and serum uric acid level were not changed significantly. The titre of Waaler-Rose reaction in four patients was decreased, in two it was increased, and in four it remained unchanged. No side effects were observed during the treatment. In the light of these observations it seems worthwhile to continue further studies on the action of isoprinosine in early rheumatoid arthritis.

Structural characteristics of a major seed albumin of Pisum sativum.

The major pea seed albumin from Pisum sativum was carboxymethylated, cleaved with CNBr, and submitted to sequence analysis of the fragments in order to characterize the structural organization of the protein chains. Four major pools of largely homogeneous CNBr fragments were obtained, and likely N- and C-terminal fragments were identified. Structural analysis suggested the presence of single positions with microheterogeneities. It also revealed structures with long segments of distinct homology (52% structural identity), indicating the presence of different but related protein chains, or less likely, of repetitive structural elements within a chain. However, preparations appear largely homogeneous in protein class, and contain similar polypeptide chains of about 200 residues in mainly hydrophilic structures, with few methionine and cysteine/half-cystine residues.