Influence of matrix metalloproteinase 9 variant rs17576 on ischemic stroke risk and severity in acute coronary syndrome.

BACKGROUND: Ischemic injury is a common mechanism in both ischemic stroke (IS) and acute coronary syndrome (ACS). Matrix metalloproteinase 9 (MMP-9), an endopeptidase that degrades extracellular matrix, is important in the pathogenesis of IS. The purpose of this study is to evaluate the association between the SNP rs17576 in MMP-9 gene with (1) the risk and severity of acute ischemic stroke in Saudi Arab individuals with recent acute coronary syndrome, and (2) the risk of acute coronary syndrome in Saudi Arab individuals without ischemic stroke. METHODS: A case control study of 200 IS patients, 520 ACS patients (without IS), and 500 aged-matched healthy controls were genotyped to detect the MMP-9 polymorphism rs17156. RESULTS: Our study demonstrated a non-significant difference in the genotype and allele frequencies of the MMP9 rs17576 polymorphism between the patients with IS and patients with ACS without IS (P = 0.31 for the GA genotype, 0.25 for the AA genotype and P = 0.20 for the A allele). AA genotype was found to be statistically significant between IS and control groups; [OR=1.84, 95 % CI (1.08-3.14), p =0.015]. A allele showed a significant difference between the two groups [OR=1.28, 95 % CI (1.00-1.64), p =0.028]. By comparing ACS without IS and controls, AA genotype was significant [OR=1.46, 95 % CI (1.01-2.12), p =0.029]. Stratification by NIHSS score revealed higher mortality and early neurologic deterioration in IS patients with NIHSS score ≥ 16 (p < 0.001, 0.044 respectively). CONCLUSION: We deduced the lack of association either with allele or genotype frequencies (p>0.05) between the IS cases and the cases of ACS without IS. In contrast there was a significant association of mutant genotype AA between either the IS group or ACS (without IS) group, and the control group. In addition, different rs17576 genotypes were not associated with raised mortality or a tendency to develop early neurologic deterioration.

Perceptions of volunteering during the COVID-19 pandemic among medical and dental professionals in Saudi Arabia.

Background: Volunteering can be defined as any action where time is freely donated to help another individual, organization, or cause. During pandemics, volunteers in the healthcare industry are essential. There were different perspectives on volunteering around the world. This study evaluated Saudi Arabia's clinical medical and dentistry students' attitudes and perspectives on volunteering during the coronavirus disease 2019 (COVID-19) pandemic. Method: A descriptive cross-sectional study of medical and dental students completing the clinical experience in Saudi Arabia. A web-based survey gathered data, and SPSS, Chi-square, and Fisher's exact tests were used for analysis. Results: The majority of participants had positive attitudes and perceptions of volunteering during COVID-19 on most items. A total of 93.80% said they would volunteer given the opportunity, and 86.25% would respond to governmental calls during health crises. However, 62.26% would volunteer only if compensated, 66.58% needed parental approval before volunteering, and 74.93% had fears about infecting family members. Nearly all items were not significantly different by specialty (medicine/dentistry), gender, nationality, region, or education level. Conclusions: Medical and dentistry professionals had good attitudes about volunteering during health disasters, especially when provided proper protection and training. The majority of participants were likely to respond to governmental calls if needed. Future studies should investigate compensation methods and types.