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1.
Burns ; 50(7): 1908-1915, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38890052

RESUMEN

BACKGROUND: Long-term cognitive impairment (LTCI) is experienced by up to two thirds of patients discharged from burns intensive care units (BICUs), however little is known about its neurobiological basis. This study investigated if patients previously admitted to BICU showed structural and functional MRI changes of the Default Mode Network (DMN). METHODS: Fifteen patients previously admitted to BICU with a significant burns injury, and 15 matched volunteers, underwent structural and functional MRI scans. Functional connectivity, fractional anisotropy and cortical thickness of the main DMN subdivisions (anterior DMN (aDMN), posterior DMN (pDMN) and right (rTPJ) and left (lTPJ) temporo-parietal junctions) were compared between patients and volunteers, with differences correlated against cognitive performance. RESULTS: Functional connectivity between rTPJ and pDMN (t = 2.91, p = 0.011) and between rTPJ and lTPJ (t = 3.18, p = 0.008) was lower in patients compared to volunteers. Functional connectivity between rTPJ and pDMN correlated with cognitive performance (r2 =0.33, p < 0.001). Mean fractional anisotropy of rTPJ (t = 2.70, p = 0.008) and lTPJ (T = 2.39, p = 0.015) was lower in patients but there was no difference in cortical thickness. CONCLUSIONS: Patients previously admitted to BICU show structural and functional disruption of the DMN. Since functional changes correlate with cognitive performance, this should direct further research into intensive-care-related cognitive impairment.


Asunto(s)
Quemaduras , Disfunción Cognitiva , Red en Modo Predeterminado , Imagen por Resonancia Magnética , Humanos , Masculino , Femenino , Quemaduras/fisiopatología , Quemaduras/diagnóstico por imagen , Quemaduras/complicaciones , Quemaduras/patología , Adulto , Persona de Mediana Edad , Red en Modo Predeterminado/diagnóstico por imagen , Red en Modo Predeterminado/fisiopatología , Disfunción Cognitiva/fisiopatología , Disfunción Cognitiva/etiología , Disfunción Cognitiva/diagnóstico por imagen , Estudios de Casos y Controles , Cuidados Críticos , Unidades de Cuidados Intensivos , Adulto Joven
2.
Magn Reson Med ; 87(3): 1446-1460, 2022 03.
Artículo en Inglés | MEDLINE | ID: mdl-34752644

RESUMEN

PURPOSE: Before MR fingerprinting (MRF) can be adopted clinically, the derived quantitative values must be proven accurate and repeatable over a range of T1 and T2 values and temperatures. Correct assessment of accuracy and precision as well as comparison between measurements can only be performed when temperature is either controlled or corrected for. The purpose of this study was to investigate the temperature dependence of T1 and T2 MRF values and evaluate the accuracy and repeatability of temperature-corrected relaxation values derived from a B1 -corrected MRF-fast imaging with steady-state precession implementation using 2 different dictionary sizes. METHODS: The International Society of MR in Medicine/National Institute of Standards and Technology phantom was scanned using an MRF sequence of 2 different lengths, a variable flip angle T1 , and a multi-echo spin echo T2 at 14 temperatures ranging from 15°C to 28°C and investigated with a linear regression model. Temperature-corrected accuracy was evaluated by correlating T1 and T2 times from each MRF dictionary with reference values. Repeatability was assessed using the coefficient of variation, with measurements taken over 30 separate sessions. RESULTS: There was a statistically significant fit of the model for MRF-derived T1 and T2 and temperature (p < 0.05) for all the spheres with a T1 > 500 ms. Both MRF methods showed a strong linear correlation with reference values for T1 (R2 = 0.996) and T2 (R2 = 0.982). MRF repeatability for T1 values was ≤1.4% and for T2 values was ≤3.4%. CONCLUSION: MRF demonstrated relaxation times with a temperature dependence similar to that of conventional mapping methods. Temperature-corrected T1 and T2 values from both dictionaries showed adequate accuracy and excellent repeatability in this phantom study.


Asunto(s)
Encéfalo , Imagen por Resonancia Magnética , Encéfalo/diagnóstico por imagen , Procesamiento de Imagen Asistido por Computador , Fantasmas de Imagen , Valores de Referencia , Reproducibilidad de los Resultados , Temperatura
3.
Radiology ; 293(2): 374-383, 2019 11.
Artículo en Inglés | MEDLINE | ID: mdl-31573402

RESUMEN

Background Treatment of advanced epithelial ovarian cancer results in a relapse rate of 75%. Early markers of response would enable optimization of management and improved outcome in both primary and recurrent disease. Purpose To assess the apparent diffusion coefficient (ADC), derived from diffusion-weighted MRI, as an indicator of response, progression-free survival (PFS), and overall survival. Materials and Methods This prospective multicenter trial (from 2012-2016) recruited participants with stage III or IV ovarian, primary peritoneal, or fallopian tube cancer (newly diagnosed, cohort one; relapsed, cohort two) scheduled for platinum-based chemotherapy, with interval debulking surgery in cohort one. Cohort one underwent two baseline MRI examinations separated by 0-7 days to assess ADC repeatability; an additional MRI was performed after three treatment cycles. Cohort two underwent imaging at baseline and after one and three treatment cycles. ADC changes in responders and nonresponders were compared (Wilcoxon rank sum tests). PFS and overall survival were assessed by using a multivariable Cox model. Results A total of 125 participants (median age, 63.3 years [interquartile range, 57.0-70.7 years]; 125 women; cohort one, n = 47; cohort two, n = 78) were included. Baseline ADC (range, 77-258 × 10-5mm2s-1) was repeatable (upper and lower 95% limits of agreement of 12 × 10-5mm2s-1 [95% confidence interval {CI}: 6 × 10-5mm2s-1 to 18 × 10-5mm2s-1] and -15 × 10-5mm2s-1 [95% CI: -21 × 10-5mm2s-1 to -9 × 10-5mm2s-1]). ADC increased in 47% of cohort two after one treatment cycle, and in 58% and 53% of cohorts one and two, respectively, after three cycles. Percentage change from baseline differed between responders and nonresponders after three cycles (16.6% vs 3.9%; P = .02 [biochemical response definition]; 19.0% vs 6.2%; P = .04 [radiologic definition]). ADC increase after one cycle was associated with longer PFS in cohort two (adjusted hazard ratio, 0.86; 95% CI: 0.75, 0.98; P = .03). ADC change was not indicative of overall survival for either cohort. Conclusion After three cycles of platinum-based chemotherapy, apparent diffusion coefficient (ADC) changes are indicative of response. After one treatment cycle, increased ADC is indicative of improved progression-free survival in relapsed disease. Published under a CC BY 4.0 license. Online supplemental material is available for this article.


Asunto(s)
Carcinoma Epitelial de Ovario/diagnóstico por imagen , Carcinoma Epitelial de Ovario/terapia , Imagen de Difusión por Resonancia Magnética/métodos , Anciano , Biomarcadores de Tumor/análisis , Carcinoma Epitelial de Ovario/patología , Terapia Combinada , Femenino , Humanos , Persona de Mediana Edad , Recurrencia Local de Neoplasia , Estadificación de Neoplasias , Estudios Prospectivos , Tasa de Supervivencia
4.
Ann Biomed Eng ; 47(4): 924-936, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-30680483

RESUMEN

Linear scaling of generic shoulder models leads to substantial errors in model predictions. Customisation of shoulder modelling through magnetic resonance imaging (MRI) improves modelling outcomes, but model development is time and technology intensive. This study aims to validate 10 MRI-based shoulder models, identify the best combinations of anthropometric parameters for model scaling, and quantify the improvement in model predictions of glenohumeral loading through anthropometric scaling from this anatomical atlas. The shoulder anatomy was modelled using a validated musculoskeletal model (UKNSM). Ten subject-specific models were developed through manual digitisation of model parameters from high-resolution MRI. Kinematic data of 16 functional daily activities were collected using a 10-camera optical motion capture system. Subject-specific model predictions were validated with measured muscle activations. The MRI-based shoulder models show good agreement with measured muscle activations. A tenfold cross-validation using the validated personalised shoulder models demonstrates that linear scaling of anthropometric datasets with the most similar ratio of body height to shoulder width and from the same gender (p < 0.04) yields best modelling outcomes in glenohumeral loading. The improvement in model reliability is significant (p < 0.02) when compared to the linearly scaled-generic UKNSM. This study may facilitate the clinical application of musculoskeletal shoulder modelling to aid surgical decision-making.


Asunto(s)
Modelos Biológicos , Músculo Esquelético/fisiología , Hombro/fisiología , Adulto , Fenómenos Biomecánicos , Femenino , Humanos , Masculino , Reproducibilidad de los Resultados
5.
Brain ; 139(Pt 12): 3137-3150, 2016 12.
Artículo en Inglés | MEDLINE | ID: mdl-27797805

RESUMEN

SEE BIGLER DOI101093/AWW277 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Post-traumatic amnesia is very common immediately after traumatic brain injury. It is characterized by a confused, agitated state and a pronounced inability to encode new memories and sustain attention. Clinically, post-traumatic amnesia is an important predictor of functional outcome. However, despite its prevalence and functional importance, the pathophysiology of post-traumatic amnesia is not understood. Memory processing relies on limbic structures such as the hippocampus, parahippocampus and parts of the cingulate cortex. These structures are connected within an intrinsic connectivity network, the default mode network. Interactions within the default mode network can be assessed using resting state functional magnetic resonance imaging, which can be acquired in confused patients unable to perform tasks in the scanner. Here we used this approach to test the hypothesis that the mnemonic symptoms of post-traumatic amnesia are caused by functional disconnection within the default mode network. We assessed whether the hippocampus and parahippocampus showed evidence of transient disconnection from cortical brain regions involved in memory processing. Nineteen patients with traumatic brain injury were classified into post-traumatic amnesia and traumatic brain injury control groups, based on their performance on a paired associates learning task. Cognitive function was also assessed with a detailed neuropsychological test battery. Functional interactions between brain regions were investigated using resting-state functional magnetic resonance imaging. Together with impairments in associative memory, patients in post-traumatic amnesia demonstrated impairments in information processing speed and spatial working memory. Patients in post-traumatic amnesia showed abnormal functional connectivity between the parahippocampal gyrus and posterior cingulate cortex. The strength of this functional connection correlated with both associative memory and information processing speed and normalized when these functions improved. We have previously shown abnormally high posterior cingulate cortex connectivity in the chronic phase after traumatic brain injury, and this abnormality was also observed in patients with post-traumatic amnesia. Patients with post-traumatic amnesia showed evidence of widespread traumatic axonal injury measured using diffusion magnetic resonance imaging. This change was more marked within the cingulum bundle, the tract connecting the parahippocampal gyrus to the posterior cingulate cortex. These findings provide novel insights into the pathophysiology of post-traumatic amnesia and evidence that memory impairment acutely after traumatic brain injury results from altered parahippocampal functional connectivity, perhaps secondary to the effects of axonal injury on white matter tracts connecting limbic structures involved in memory processing.


Asunto(s)
Amnesia/fisiopatología , Lesiones Traumáticas del Encéfalo/fisiopatología , Giro del Cíngulo/fisiopatología , Imagen por Resonancia Magnética/métodos , Red Nerviosa/fisiopatología , Giro Parahipocampal/fisiopatología , Adulto , Amnesia/diagnóstico por imagen , Amnesia/etiología , Aprendizaje por Asociación/fisiología , Lesiones Traumáticas del Encéfalo/complicaciones , Lesiones Traumáticas del Encéfalo/diagnóstico por imagen , Femenino , Giro del Cíngulo/diagnóstico por imagen , Humanos , Masculino , Memoria a Corto Plazo/fisiología , Persona de Mediana Edad , Red Nerviosa/diagnóstico por imagen , Giro Parahipocampal/diagnóstico por imagen , Memoria Espacial/fisiología , Adulto Joven
6.
Med Phys ; 43(1): 95, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-26745903

RESUMEN

PURPOSE: To develop methods for optimization of diffusion-weighted MRI (DW-MRI) in the abdomen and pelvis on 1.5 T MR scanners from three manufacturers and assess repeatability of apparent diffusion coefficient (ADC) estimates in a temperature-controlled phantom and abdominal and pelvic organs in healthy volunteers. METHODS: Geometric distortion, ghosting, fat suppression, and repeatability and homogeneity of ADC estimates were assessed using phantoms and volunteers. Healthy volunteers (ten per scanner) were each scanned twice on the same scanner. One volunteer traveled to all three institutions in order to provide images for qualitative comparison. The common volunteer was excluded from quantitative analysis of the data from scanners 2 and 3 in order to ensure statistical independence, giving n = 10 on scanner 1 and n = 9 on scanners 2 and 3 for quantitative analysis. Repeatability and interscanner variation of ADC estimates in kidneys, liver, spleen, and uterus were assessed using within-patient coefficient of variation (wCV) and Kruskal-Wallis tests, respectively. RESULTS: The coefficient of variation of ADC estimates in the temperature-controlled phantom was 1%-4% for all scanners. Images of healthy volunteers from all scanners showed homogeneous fat suppression and no marked ghosting or geometric distortion. The wCV of ADC estimates was 2%-4% for kidneys, 3%-7% for liver, 6%-9% for spleen, and 7%-10% for uterus. ADC estimates in kidneys, spleen, and uterus showed no significant difference between scanners but a significant difference was observed in liver (p < 0.05). CONCLUSIONS: DW-MRI protocols can be optimized using simple phantom measurements to produce good quality images in the abdomen and pelvis at 1.5 T with repeatable quantitative measurements in a multicenter study.


Asunto(s)
Abdomen , Imagen de Difusión por Resonancia Magnética/métodos , Pelvis , Tejido Adiposo , Adulto , Artefactos , Dimetilpolisiloxanos , Femenino , Humanos , Persona de Mediana Edad , Fantasmas de Imagen , Relación Señal-Ruido , Sacarosa , Temperatura , Adulto Joven
7.
J Cardiovasc Magn Reson ; 12: 5, 2010 Jan 14.
Artículo en Inglés | MEDLINE | ID: mdl-20074359

RESUMEN

AIMS: Cardiovascular magnetic resonance (CMR) allows non-invasive phase contrast measurements of flow through planes transecting large vessels. However, some clinically valuable applications are highly sensitive to errors caused by small offsets of measured velocities if these are not adequately corrected, for example by the use of static tissue or static phantom correction of the offset error. We studied the severity of uncorrected velocity offset errors across sites and CMR systems. METHODS AND RESULTS: In a multi-centre, multi-vendor study, breath-hold through-plane retrospectively ECG-gated phase contrast acquisitions, as are used clinically for aortic and pulmonary flow measurement, were applied to static gelatin phantoms in twelve 1.5 T CMR systems, using a velocity encoding range of 150 cm/s. No post-processing corrections of offsets were implemented. The greatest uncorrected velocity offset, taken as an average over a 'great vessel' region (30 mm diameter) located up to 70 mm in-plane distance from the magnet isocenter, ranged from 0.4 cm/s to 4.9 cm/s. It averaged 2.7 cm/s over all the planes and systems. By theoretical calculation, a velocity offset error of 0.6 cm/s (representing just 0.4% of a 150 cm/s velocity encoding range) is barely acceptable, potentially causing about 5% miscalculation of cardiac output and up to 10% error in shunt measurement. CONCLUSION: In the absence of hardware or software upgrades able to reduce phase offset errors, all the systems tested appeared to require post-acquisition correction to achieve consistently reliable breath-hold measurements of flow. The effectiveness of offset correction software will still need testing with respect to clinical flow acquisitions.


Asunto(s)
Aorta/fisiopatología , Gasto Cardíaco , Imagen por Resonancia Cinemagnética/instrumentación , Insuficiencia de la Válvula Mitral/diagnóstico , Fantasmas de Imagen , Arteria Pulmonar/fisiopatología , Artefactos , Velocidad del Flujo Sanguíneo , Gelatina , Humanos , Interpretación de Imagen Asistida por Computador , Ensayo de Materiales , Insuficiencia de la Válvula Mitral/fisiopatología , Valor Predictivo de las Pruebas , Reproducibilidad de los Resultados , Mecánica Respiratoria
8.
Sleep Med ; 4(5): 451-4, 2003 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-14592287

RESUMEN

OBJECTIVE: Obstructive sleep apnea (OSA) causes hypoxemia and fragmented sleep, which lead to neurocognitive deficits. We hypothesised that focal loss of cortical gray matter generally within areas associated with memory processing and learning and specifically within the hippocampus would occur in OSA. METHODS: Voxel-based morphometry, an automated processing technique for magnetic resonance images, was used to characterise structural changes in gray matter in seven right handed, male patients with newly diagnosed OSA and seven non-apneic, male controls matched for handedness and age. RESULTS: The analysis revealed a significantly lower gray matter concentration within the left hippocampus (p=0.004) in the apneic patients. No further significant focal gray matter differences were seen in the right hippocampus and in other brain regions. There was no difference in total gray matter volume between apneics and controls. CONCLUSION: This preliminary report indicates changes in brain morphology in OSA, in the hippocampus, a key area for cognitive processing.


Asunto(s)
Encéfalo/patología , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Apnea Obstructiva del Sueño/diagnóstico , Estudios de Casos y Controles , Estudios Transversales , Hipocampo/patología , Humanos , Masculino , Sustancia Gris Periacueductal/patología
9.
J Aerosol Med ; 16(4): 401-15, 2003.
Artículo en Inglés | MEDLINE | ID: mdl-14977431

RESUMEN

The oropharyngeal region of the human airways has been scanned using 3D MRI and the data used to produce a model cast. The scanning method used a triggering device, which enabled data collection at the same pressure drop in each breathing cycle to produce clear images free of motion-related artefacts. A comparison between two differing MR acquisition strategies was made in a single subject, multi-session study. 3D FISP MR imaging was found to produce the most reliable data. Excluding the buccal cavity, where tongue position was critical, the reproducibility of measured airway volumes and cross sectional areas between sessions was demonstrated. Inter-session total airway volume (excluding the mouth) reproducibility was of the order of 5% and for minimum cross sectional areas at the epiglottis and vocal cords was 10%. The production of a physical cast from the images led to a 5% increase in airway volume compared with the anatomical images but with some loss of fine detail. The data demonstrated the robustness of an ex-vivo means of studying oropharyngeal dimensions and dynamics which may contribute to advancements in the understanding of aerosol delivery of therapeutic agents.


Asunto(s)
Aerosoles/farmacocinética , Imagen por Resonancia Magnética/métodos , Orofaringe/anatomía & histología , Aerosoles/farmacología , Disponibilidad Biológica , Humanos , Procesamiento de Imagen Asistido por Computador , Pulmón/efectos de los fármacos , Modelos Anatómicos , Nebulizadores y Vaporizadores , Mecánica Respiratoria , Sensibilidad y Especificidad
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