1.
Pharmazie
; 53(9): 620-4, 1998 Sep.
Artículo
en Alemán
| MEDLINE
| ID: mdl-9770210
RESUMEN
Chlormezanone, a chiral centrally acting muscle relaxant, will be cleaved at its S-C-1 bond by an autoprotolytic process. The optimum of chemical stability exists between pH 2 up to pH 9 with a maximum at pH 7.4. The plasma half life at 37 degrees C is 76 h. Enzymes do attack the products of cleavage namely 4-chlorobenzaldehyde and 2-carboxyethane-sulfinic-acid-N-methyl-amide. The main metabolite in urine is 4-chlorohippuric acid in the range of up to 70% of the oral administered dose to humans. No cytochrome P-450 is engaged in the cleavage of the S-C-bond.
Asunto(s)
Clormezanona/farmacocinética , Relajantes Musculares Centrales/farmacocinética , Biotransformación , Cromatografía Líquida de Alta Presión , Semivida , Humanos
2.
J Hosp Infect
; 6 Suppl A: 13-23, 1985 Mar.
Artículo
en Inglés
| MEDLINE
| ID: mdl-2860158