1.
Chem Commun (Camb)
; 54(21): 2599-2602, 2018 Mar 08.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29388990
RESUMEN
The inverse electron-demand Diels-Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radiosynthesis of 225Ac-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothiocyanate couplings.