RESUMEN
Because hepatitis A infection may be more severe in patients with chronic liver disease, we vaccinated 33 children who were chronic HBsAg carriers against hepatitis A virus. Anti-hepatitis A virus seroconversion rates after the first, second, and third doses were 90.9%, 96.9%, and 100%, respectively.
Asunto(s)
Hepatitis A/prevención & control , Antígenos de Superficie de la Hepatitis B/análisis , Virus de la Hepatitis B/inmunología , Hepatitis B Crónica/inmunología , Vacunas contra Hepatitis Viral/administración & dosificación , Adolescente , Portador Sano , Niño , Preescolar , Femenino , Hepatitis A/inmunología , Vacunas contra la Hepatitis A , Humanos , Masculino , Vacunación , Vacunas contra Hepatitis Viral/inmunologíaRESUMEN
Here we describe the case of a 14-year-old boy who underwent liver transplantation for post-Kasai biliary atresia when aged 4. Antirejection treatment consisted of prednisone and cyclosporine. At the age of 11 years the patient developed left cervical lymphadenopathy; the biopsy showed classical Hodgkin's disease(HD) of the mixed cellularity (MC) type. Neoplastic cells expressed CD30 and CD15, and were negative for CD45, CD20, CD3, CD43, and CD79a. Furthermore, they carried the EBV-related products LMP1 and EBER1/2. Treatment consisted of three cycles of adriamycin, bleomycin, vinblastine and DTIC (ABVD), followed by radiotherapy (2,000 cGys) on involved fields. At present, 42 months after the diagnosis of HD, the patient is still in complete remission. This is, to the best of our knowledge, the first reported case of classical HD following liver transplantation. The positivity of neoplastic cells for LMP1 and EBER1/2 indicates a possible role for immunosuppression in the development of the tumor, and whether a reduction in immunosuppression might have influenced the course of the disease is open to question.
Asunto(s)
Enfermedad de Hodgkin/etiología , Enfermedad de Hodgkin/patología , Trasplante de Hígado/efectos adversos , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Atresia Biliar/cirugía , Biopsia con Aguja , Terapia Combinada , Supervivencia sin Enfermedad , Enfermedad de Hodgkin/terapia , Humanos , Inmunohistoquímica , Hibridación in Situ , Ganglios Linfáticos/patología , Masculino , RadioterapiaRESUMEN
Alagille syndrome is a rare autosomal dominant developmental disorder, characterized by congenital paucity of interlobular bile ducts, peculiar facies, posterior embryotoxon, bone abnormalities, and peripheral pulmonary artery stenosis. Cutaneous involvement in this disorder is quite rare and the association of Alagille syndrome with multiple comedones and cysts has been described only once. Here, we report the clinical and histological findings of a 7-year-old patient affected by Alagille syndrome who presented multiple cystic lesions and comedones reminiscent of steatocystoma multiplex and a congenital total true leuconychia. Although unexplained, the association of this syndrome with a developmental disorder of the pilosebaceous unit may not be fortuitous.