Frequency of invasive cancer in surgically excised vulvar lesions with intraepithelial neoplasia (VIN 3).

OBJECTIVE: The aim of this study was to determine the frequency of invasive cancer found from specimens removed by surgical excision on patients with diagnosis of VIN 3. METHODS: Seventy-eight patients with biopsy-proven vulvar intraepithelial neoplasia 3 (VIN 3) were treated by surgical excision. RESULTS: Sixteen patients (20.5%) were found to have invasion in the excised surgical specimen. Superficial invasion was seen in 7 patients (9%), 9 were noted to have >1 mm invasion (11.5%), and 1 patient had in situ Paget's disease (1.3%). CONCLUSION: Surgical excision should be considered a preferable method in management of patients with VIN 3.