Unusual Magnetic Hysteresis and Transition between Vortex and Double Pole States Arising from Interlayer Coupling in Diamond-Shaped Nanostructures.

Controlling the magnetic ground states at the nanoscale is a long-standing basic research problem and an important issue in magnetic storage technologies. Here, we designed a nanostructured material that exhibits very unusual hysteresis loops due to a transition between vortex and double pole states. Arrays of 700 nm diamond-shaped nanodots consisting of Py(30 nm)/Ru(tRu)/Py(30 nm) (Py, permalloy (Ni80Fe20)) trilayers were fabricated by interference lithography and e-beam evaporation. We show that varying the Ru interlayer spacer thickness (tRu) governs the interaction between the Py layers. We found this interaction mainly mediated by two mechanisms: magnetostatic interaction that favors antiparallel (antiferromagnetic, AFM) alignment of the Py layers and exchange interaction that oscillates between ferromagnetic (FM) and AFM couplings. For a certain range of Ru thicknesses, FM coupling dominates and forms magnetic vortices in the upper and lower Py layers. For Ru thicknesses at which AFM coupling dominates, the magnetic state in remanence is a double pole structure. Our results showed that the interlayer exchange coupling interaction remains finite even at 4 nm Ru thickness. The magnetic states in remanence, observed by magnetic force microscopy (MFM), are in good agreement with corresponding hysteresis loops obtained by the magneto-optic Kerr effect (MOKE) and micromagnetic simulations.

Priapism Produced by Penile Metastasis from Colon Cancer

Introduction and Objective: The penile metastasis is a rare clinical entity. The objective is to present the first documented case report of penile metastasis from right colon. Clinical Case: A case of a 78-year-old man who was diagnosed with penile metastasis from right colon. The patient came to our consultation complaining of colic pain in the kidney and swelling of the penile which finally result in a malignant priapism. The diagnosis was histopathologic and was treated with chemotherapy and died few months later. Conclusion: Metastatic lesions in the penile are extremely rare; only 300 cases have been reported in the literature. It is a sign of bad prognosis. The mechanism of metastatic spread to the penis is not well established. Even there are several treatment options, is usually paliative (AU)

Introducción y Objetivo: La metástasis penena esuna entidad muy infrecuente. El objetivo es la presentacióndel primer caso documentado en la literatura de metástasispenana con origen en el colon derecho.Caso Clínico: Presentamos a un varón diagnosticadode priapismo producido por una metástasis peneana cuyotumor primitivo tiene lugar en el colon derecho. El pacienteacudió por dolor en fosa renal y éstasis venoso en el peneque finalmente le provocó un priapismo por afectación tumoral. El diagnóstico fue anatomopatológico, siendo el paciente tratado con quimioterapia.Conclusión: La presencia de metástasis en el penees una presentación clínica infrecuente y un signo de malpronóstico. El mecanismo fisiopatológico no está determinado. El tratamiento, aunque variado, es generalmente paliativo (AU)

Cetylpyridinium Chloride Mouthwash to Reduce Shedding of Infectious SARS-CoV-2: A Double-Blind Randomized Clinical Trial.

The airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via respiratory fluids and droplets suggests that mouthwashes containing substances with virucidal activity can help reduce viral spread. We conducted a multicenter, double-blind, placebo-controlled, randomized trial to assess the virucidal activity of cetylpyridinium chloride (CPC) mouthwashes. Outpatients who tested positive for SARS-CoV-2 infection with or without symptoms were randomized to perform washes and gargles for 1 min with 15 mL of either colored distilled water or 0.07% CPC (Vitis CPC Protect) mouthwash. The study outcomes were the SARS-CoV-2 log10 viral RNA load and the nucleocapsid protein levels, both in saliva at 1 and 3 h after the intervention. In total, 118 patients were enrolled and randomized (mean [SD], age 46 [14] y). Thirteen of 118 participants (11%) did not complete follow-up or had insufficient sample volume for testing and were excluded from the analysis. The assessment of the viral load showed no significant differences between groups at any of the investigated points. However, the levels of SARS-CoV-2 nucleocapsid protein of lysed viruses were significantly higher in the CPC group compared with the control group at 1 h (adjusted difference 269.3 pg/mL; 95% confidence interval [CI], 97.1-441.5) and at 3 h postintervention (561.1 pg/mL; 95% CI, 380.0-742.2). In nonhospitalized patients with asymptomatic or mild symptomatic SARS-CoV-2 infection, a 0.07% CPC mouthwash, compared to placebo, was associated with a significant increase of nucleocapsid protein levels in saliva, indicating enhanced disruption of viral particles.

Biocompatible iron(iii) carboxylate metal-organic frameworks as promising RNA nanocarriers.

Despite the great interest in RNA therapeutics, the development of a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapment into the mesopores of biocompatible nanoscaled metal-organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.

Body dysmorphic disorder in patients with acne: a multicentre study.

BACKGROUND AND OBJECTIVE: Body dysmorphic disorder (BDD) is a mental disorder that is difficult to diagnose, causes a lot of suffering and is more prevalent in dermatology patients than in the general population. Our objective was to screen for possible cases of BDD in patients with acne and to determine the prevalence according to DSM-IV and DSM-5 criteria, as well as to analyse the relationship between dermatological and sociodemographic variables. METHODS: A total of 245 patients diagnosed with acne in 11 dermatological centres in Spain were included in the study by members of the Aragon Psychodermatology Research Group and Spanish Research Group of Psychiatric Dermatology. We used the Body Dysmorphic Disorder Questionnaire (BDDQ) as a screening tool. RESULTS: In our sample, we obtained a prevalence for BDD of 10.6% (95% CI: 7.6-13.6%). The prevalence was the same with DSM-IV or DSM-5 criteria. Possible cases of BDD were predominantly women (P = 0.021), and 56% had non-inflammatory lesions vs. 30% of negative patients (P = 0.002). Positive patients as possible cases of BDD spent more than two hours on average a day worrying about their appearance. Most people only worried about one part of their body (86%), and in 95% of the cases, the part of their body that worried them was the face. The three most frequent compulsive behaviours in patients who screened positive for BDD were mirror checking (90.7%), camouflaging (79.1%) and using make-up (72.1%). CONCLUSIONS: As a consequence of the high prevalence of possible cases of BDD in patients with acne observed in our study, there is a need for dermatologists to screen for BDD so that they can be referred to a mental health unit to confirm the diagnosis and be offered treatment to reduce the progression of psychosocial deterioration and the development of comorbid disorders.

Chiral asymmetry detected in a 2D array of permalloy square nanomagnets using circularly polarized x-ray resonant magnetic scattering.

The sensitivity of circularly polarized x-ray resonant magnetic scattering (CXRMS) to chiral asymmetry has been demonstrated. The study was performed on a 2D array of Permalloy (Py) square nanomagnets of 700 nm lateral size arranged in a chess pattern, in a square lattice of 1000 nm lattice parameter. Previous x-ray magnetic circular dichroism photoemission electron microscopy (XMCD-PEEM) images on this sample showed the formation of vortices at remanence and a preference in their chiral state. The magnetic hysteresis loops of the array along the diagonal axis of the squares indicate a non-negligible and anisotropic interaction between vortices. The intensity of the magnetic scattering using circularly polarized light along one of the diagonal axes of the square magnets becomes asymmetric in intensity in the direction transversal to the incident plane at fields where the vortex states are formed. The asymmetry sign is inverted when the direction of the applied magnetic field is inverted. The result is the expected in the presence of an unbalanced chiral distribution. The effect is observed by CXRMS due to the interference between the charge scattering and the magnetic scattering.

Complicaciones viscerales y gastrointestinales en la cirugía urológica robótica / Visceral and gastrointestinal complications in robotic urologic surgery

Introducción: Con el uso generalizado de técnicas mínimamente invasivas la cirugía urológica asistida por robot ha sido ampliamente adoptada. A pesar de su infrecuencia, las complicaciones viscerales y gastrointestinales podrían poner en peligro la vida. Objetivos: Identificar las principales lesiones gastrointestinales que ocurren en una cirugía urológica asistida por robot. Conocer la incidencia general y cómo es su manejo. Adquisición de la evidencia: Búsqueda en PubMed de artículos relacionados con complicaciones viscerales y gastrointestinales en cirugía urológica asistida por robot, escritos en inglés o español. Se revisaron publicaciones relevantes, así como revisiones de literatura y capítulos de libros. Síntesis de la evidencia: Junto con las lesiones vasculares, las lesiones viscerales y gastrointestinales se encuentran entre las complicaciones más peligrosas. Un estudio preoperatorio completo para individualizar las características de cada paciente y el uso correcto de la toma de imágenes podría ayudarnos a evitar complicaciones en primer lugar. Conocer todos los pasos arriesgados en los diferentes procedimientos urológicos robóticos nos permitirá anticipar los daños. El conocimiento de las lesiones principales y más peligrosas en los diferentes órganos abdominales y pélvicos es altamente recomendable. El diagnóstico precoz y la evaluación de las lesiones nos permitirán un manejo agudo durante la cirugía. El retraso en el reconocimiento podría convertir una lesión reparable a una situación potencialmente mortal. Conclusiones: A pesar de los beneficios innegables del enfoque robótico, hay lesiones gastrointestinales menores y mayores que todos los cirujanos urológicos deben saber. Los relacionados con la colocación de trocares son especialmente importantes. El diagnóstico y el manejo inmediatos son obligatorios

Introduction: with the widespread use of minimally invasive techniques, robot-assisted urologic surgery has become widely adopted. Despite their infrequency, visceral and gastrointestinal complications could be life-threatening. Objectives: To identify the main gastrointestinal injuries that occur in a robot-assisted urologic surgery. To know the overall incidence and how is their management. Acquisition of the evidence: Search in PubMed of articles related to visceral and gastrointestinal complications in robot-assisted urology surgery, written in English or Spanish. Relevant publications as well literature reviews and chapters from books were reviewed. Synthesis of the evidence: Along with vascular injuries, visceral and gastrointestinal lesions are among most dangerous complications. A complete preoperative study to individualize each patient characteristics and the correct use of imaging could help us to avoid complications in the first place. To know all the risky steps in the different robotic urologic procedures will let us anticipate the damage. Knowledge of main and most dangerous injuries in the different abdominal and pelvic organs is fully recommended. Early diagnosis and evaluation of lesions will let us an acute management during surgery. Recognition delay could change a repairable injury into a life-threatening situation. Conclusions: Despite the undeniable benefits of robotic approach, there are minor and major gastrointestinal injuries that all urologic surgeons must know. Those related with trocar placement are especially important. Immediate diagnosis and management is mandatory

Visceral and gastrointestinal complications in robotic urologic surgery. / Complicaciones viscerales y gastrointestinales en la cirugía urológica robótica.

INTRODUCTION: with the widespread use of minimally invasive techniques, robot-assisted urologic surgery has become widely adopted. Despite their infrequency, visceral and gastrointestinal complications could be life-threatening. OBJECTIVES: To identify the main gastrointestinal injuries that occur in a robot-assisted urologic surgery. To know the overall incidence and how is their management. ACQUISITION OF THE EVIDENCE: Search in PubMed of articles related to visceral and gastrointestinal complications in robot-assisted urology surgery, written in English or Spanish. Relevant publications as well literature reviews and chapters from books were reviewed. SYNTHESIS OF THE EVIDENCE: Along with vascular injuries, visceral and gastrointestinal lesions are among most dangerous complications. A complete preoperative study to individualize each patient characteristics and the correct use of imaging could help us to avoid complications in the first place. To know all the risky steps in the different robotic urologic procedures will let us anticipate the damage. Knowledge of main and most dangerous injuries in the different abdominal and pelvic organs is fully recommended. Early diagnosis and evaluation of lesions will let us an acute management during surgery. Recognition delay could change a repairable injury into a life-threatening situation. CONCLUSIONS: Despite the undeniable benefits of robotic approach, there are minor and major gastrointestinal injuries that all urologic surgeons must know. Those related with trocar placement are especially important. Immediate diagnosis and management is mandatory.

Mácula eritematosa dolorosa en el tobillo de una mujer joven / Painful erythematous macular lesion in the ankle of a young woman

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Análisis comparativo entre nefrectomía parcial LESS híbrida y laparoscópica convencional multipuerto / Comparative study of hybrid laparoendoscopic single-site (LESS) partial nephrectomy and conventional multiport laparoscopy

Objetivo: Comparar resultados operatorios y oncológicos de la nefrectomía parcial realizada mediante abordaje laparoendoscópico a través de puerto único (LESS) reutilizable y laparoscópico multipuerto. Material y método: Estudio comparativo prospectivo pareado no aleatorizado de pacientes tratados con nefrectomía parcial mediante abordaje LESS híbrido con trocar auxiliar de 3,5 mm (n = 20) y con laparoscopia multipuerto convencional (n = 26). Resultados: La media de seguimiento fue 31 ± 18,6 meses. Un caso LESS (5%) se reconvirtió a laparoscopia. No hubo diferencias significativas entre grupos con respecto a edad, sexo, índice de masa corporal, lateralidad, localización, tamaño tumoral o empleo de doble-J; aunque hubo dominancia de ASA-I (p = 0,09) y de histología benigna (p = 0,05) en el grupo LESS. Tampoco hubo diferencias en tiempo operatorio, tiempo de isquemia, empleo de materiales hemostáticos, sangrado estimado, hemoglobina postoperatoria, transfusión u otras complicaciones. Ningún caso precisó ampliar herida cutánea para extracción de espécimen. Los pacientes LESS tuvieron menor tiempo de drenaje (p = 0,006) y menor estancia hospitalaria (p = 0,003). No hubo diferencias en número ni severidad de complicaciones según escala Clavien-Dindo. Un paciente en grupo laparoscópico falleció por TEP tras el alta hospitalaria. No hubo márgenes positivos ni recidivas o progresión de la enfermedad tumoral en el tiempo evaluado. Conclusiones: La nefrectomía parcial LESS no implica ventajas en resultados operatorios salvo menor estancia hospitalaria, posiblemente debido a hemostasia operatoria más precisa y/o selección de casos. No conlleva riesgos operatorios y oncológicos, pero tampoco supone mejora en tiempo de isquemia, pérdida hemática o tasa de transfusión. Tampoco supone una ventaja evidente en términos cosméticos

Objective: To investigate the surgical and oncological outcomes of hybrid laparoendoscopic single-site (LESS) in partial nephrectomy with reusable components compared with multiport laparoscopy. Material and method: Hybrid LESS technique with auxiliary 3.5mm trocar (n = 20) was compared with conventional multiport laparoscopy (n = 26) by a prospective, paired, nonrandomized, and comparative study in partially nephrectomized patients. Results: Follow-up average was 31 ± 18.6 months. In one case, LESS was converted to laparoscopy. No differences were found regarding age, sex, body mass index, laterality, localization, tumor size or use of double J stent. Dominance of Loop-I (P = 0.09) and benign histology (P = 0.05) were observed in the LESS group. Neither there were differences regarding operating time, ischemia time, use of hemostatic materials, estimated blood loss, postoperative hemoglobin levels, transfusion or other complications. In any case, to extend the skin incision for specimen extraction was not necessary. Drainage time (P = 0.006) and hospital stay (P = 0.003) were better in LESS patients. Concerning complications, no significant differences were observed according Clavien-Dindo scale. In laparoscopic group one patient died of pulmonary embolism after hospital discharge. No positive margins were observed in any case. During follow-up neither tumor recurrence nor disease progression were observed. Conclusions: Regarding surgical outcomes, partial nephrectomy by LESS technique does not imply improvements, excepting shorter hospital stay, probably due to accurate surgical hemostasis and/or selection of cases. No surgical and oncological risks are involved, as well as no improvement in ischemia time, blood loss or transfusion rate. We find no significant difference in cosmetic outcomes

Differences Between Men and Women in Chronic Scratching: A Psychodermatologic Study in Lichen Simplex Chronicus / Diferencias de personalidad entre hombres y mujeres con liquen simple crónico. Implicaciones para la conducta de rascado crónico

Introduction: Chronic scratching is common to many skin disorders. Being a female and presenting a high level of psychopathology are risk factors for chronic scratching. Yet, it is unclear why. Certain personality characteristics that are more prevalent in women are also known to influence emotional states (i.e. emotional tension). Objective: The present study aims to explore whether these personality styles might help understand why gender and emotional distress are associated with scratching. Material and methods: We compared the personality patterns of 103 patients (69.9% women) diagnosed with Lichen Simplex Chronicus, against a sample of healthy individuals. Results: Significant differences were found in the personality styles of men and women with LSC. Women were more pessimistic, oriented to fulfil the needs of others, traditional, insecure, submissive, and reserved, with moderate (d= .43) to strong (d= .96) size effects ranges. Some of these differences, such as in traditionalism, dutifulness, other-orientation, and pessimism, were also observed when compared with healthy men and women, with small (d= .03) to moderate (d= .47) size effects ranges. Conclusions: These psychological factors may help explain the mechanisms underlying gender differences in chronic scratching, at least in Lichen Simplex Chronicus. The findings might open new avenues for research and treatment (AU)

Introducción: El rascado crónico es común a varias enfermedades dermatológicas. Ser mujer y presentar niveles elevados de psicopatología son factores de riesgo para el rascado crónico. Sin embargo, aún se desconoce la causa de esta relación. Ciertas características de personalidad relacionadas con el estrés son más prevalentes en mujeres. Objetivo: Explorar si los estilos de personalidad pueden explicar las diferencias entre hombres y mujeres en las variables psicológicas asociadas con el rascado crónico. Material y métodos: Comparamos los perfiles de personalidad de 103 pacientes (69,9% mujeres) diagnosticados de liquen simple crónico y una muestra de sujetos sanos. Resultados: Se encontraron diferencias estadísticamente significativas entre hombres y mujeres con liquen simple crónico, siendo las mujeres más pesimistas, orientadas a los demás, tradicionales, inseguras, sumisas y reservadas en cuanto a sus emociones negativas, con rangos del tamaño del efecto entre moderados (d = 0,43) y altos (d = 0,96). También se encontraron entre la muestra de liquen simple crónico y los controles, como por ejemplo en tradicionalismo, sumisión, orientación al otro y pesimismo, con rangos del tamaño del efecto entre bajos (d = 0,03) y moderados (d = 0,47). Conclusiones: Estos hallazgos podrían ayudar a explicar los mecanismos subyacentes a las diferencias de sexo en rascado crónico, al menos en el liquen simple crónico (AU)

Differences Between Men and Women in Chronic Scratching: A Psychodermatologic Study in Lichen Simplex Chronicus.

INTRODUCTION: Chronic scratching is common to many skin disorders. Being a female and presenting a high level of psychopathology are risk factors for chronic scratching. Yet, it is unclear why. Certain personality characteristics that are more prevalent in women are also known to influence emotional states (i.e. emotional tension). OBJECTIVE: The present study aims to explore whether these personality styles might help understand why gender and emotional distress are associated with scratching. MATERIAL AND METHODS: We compared the personality patterns of 103 patients (69.9% women) diagnosed with Lichen Simplex Chronicus, against a sample of healthy individuals. RESULTS: Significant differences were found in the personality styles of men and women with LSC. Women were more pessimistic, oriented to fulfil the needs of others, traditional, insecure, submissive, and reserved, with moderate (d=.43) to strong (d=.96) size effects ranges. Some of these differences, such as in traditionalism, dutifulness, other-orientation, and pessimism, were also observed when compared with healthy men and women, with small (d=.03) to moderate (d=.47) size effects ranges. CONCLUSIONS: These psychological factors may help explain the mechanisms underlying gender differences in chronic scratching, at least in Lichen Simplex Chronicus. The findings might open new avenues for research and treatment.

Estudio comparativo entre laparoscopia multipuerto y LESS umbilical con plataforma reutilizable en el tratamiento de las masas renales / Comparative study of multiport laparoscopy and umbilical laparoendoscopic single-site surgery with reusable platform for treating renal masses

Introducción: La cirugía umbilical laparoendoscópica por puerto único (LESS) es una modalidad de uso creciente en el tratamiento de las masas renales. Se presenta una comparación prospectiva entre cirugía renal LESS y laparoscopia convencional. Material y método: Estudio pareado comparativo que evalúa resultados operatorios y complicaciones en pacientes con neoplasia renal tratada con cirugía LESS (n = 49) o laparoscopia multipuerto (n = 53). El abordaje LESS se realizó con material reutilizable colocado en el ombligo e instrumentos curvos de doble rotación, y en el 69,4% se empleó un puerto adicional de 3,5 mm. Se evalúan datos demográficos, tipo de técnica (nefrectomía, nefrectomía parcial o nefroureterectomía), tiempo operatorio, pérdida hemática, hemoglobina, necesidad de transfusión, número y gravedad de complicaciones (Clavien-Dindo), estancia hospitalaria, datos histológicos y pronóstico. Resultados: No hubo diferencias en seguimiento, edad, sexo, IMC, hemoglobina preoperatoria o tipo de cirugía. Hubo conversión en 2 casos (uno en cada grupo). El tiempo operatorio fue equivalente (p = 0,6). Transfusión intraoperatoria (p = 0,03) y pérdida hemática (p < 0,0001) fue menor en LESS, la hemoglobina postoperatoria mayor (p < 0,0001) y se emplearon también agentes hemostáticos más frecuentemente (p < 0,0001). No hubo diferencias en número (p = 0,6) ni gravedad (p = 0,47) de complicaciones. La estancia (p < 0,0001), la proporción de pacientes con drenaje (p = 0,04) y el número de días con drenaje (p = 0,0004) fueron menores en LESS. Un 25% de las lesiones intervenidas con LESS fueron benignas, pero el tamaño medio fue similar en ambos grupos (p = 0,5). La recurrencia y/o progresión tumoral fue más frecuente en laparoscopia multipuerto (p = 0,0013). Conclusiones: La cirugía LESS umbilical con plataforma reutilizable permite realizar diferentes técnicas quirúrgicas para el tratamiento de masas renales con consumo de tiempo y seguridad equiparable a laparoscopia convencional. El abordaje LESS resulta ventajoso en términos de pérdida hemática y estancia hospitalaria

Introduction: Umbilical laparoendoscopic single-site (LESS) surgery is an increasingly used modality for treating renal masses. We present a prospective comparison between LESS renal surgery and conventional laparoscopy. Material and method: A comparative paired study was conducted that evaluated the surgical results and complications of patients with renal neoplasia treated with LESS surgery (n = 49) or multiport laparoscopy (n = 53). The LESS approach was performed with reusable material placed in the navel and double-rotation curved instruments. An additional 3.5-mm port was employed in 69.4% of the cases. We assessed demographic data, the type of technique (nephrectomy, partial nephrectomy and nephroureterectomy), surgical time, blood loss, haemoglobin, need for transfusion, number and severity of complications (Clavien-Dindo), hospital stay, histological data and prognosis. Results: There were no differences in follow-up, age, sex, body mass index, preoperative haemoglobin levels or type of surgery. Conversion occurred in 2 cases (1 in each group). The surgical time was equivalent (P = .6). Intraoperative transfusion (P = .03) and blood loss (P < .0001) was lower with LESS, postoperative haemoglobin levels were higher (P < .0001) and haemostatic agents were used more frequently (P < .0001). There were no differences in the number (P = .6) or severity (P = .47) of complications. The length of stay (P < .0001), the proportion of patients with drainage (P = .04) and the number of days with drainage (P = .0004) were lower in LESS. Twenty-five percent of the lesions operated on with LESS were benign, but the mean size was similar in the 2 groups (P = .5). Tumour recurrence and/or progression were more frequent in multiport laparoscopy (P = .0013). Conclusions: Umbilical LESS surgery with reusable platform enables various surgical techniques to be performed when treating renal masses, with time consumption and safety comparable to conventional laparoscopy. The LESS approach is advantageous in terms of blood loss and hospital stay

Comparative study of multiport laparoscopy and umbilical laparoendoscopic single-site surgery with reusable platform for treating renal masses. / Estudio comparativo entre laparoscopia multipuerto y LESS umbilical con plataforma reutilizable en el tratamiento de las masas renales.

INTRODUCTION: Umbilical laparoendoscopic single-site (LESS) surgery is an increasingly used modality for treating renal masses. We present a prospective comparison between LESS renal surgery and conventional laparoscopy. MATERIAL AND METHOD: A comparative paired study was conducted that evaluated the surgical results and complications of patients with renal neoplasia treated with LESS surgery (n=49) or multiport laparoscopy (n=53). The LESS approach was performed with reusable material placed in the navel and double-rotation curved instruments. An additional 3.5-mm port was employed in 69.4% of the cases. We assessed demographic data, the type of technique (nephrectomy, partial nephrectomy and nephroureterectomy), surgical time, blood loss, haemoglobin, need for transfusion, number and severity of complications (Clavien-Dindo), hospital stay, histological data and prognosis. RESULTS: There were no differences in follow-up, age, sex, body mass index, preoperative haemoglobin levels or type of surgery. Conversion occurred in 2 cases (1 in each group). The surgical time was equivalent (P=.6). Intraoperative transfusion (P=.03) and blood loss (P<.0001) was lower with LESS, postoperative haemoglobin levels were higher (P<.0001) and haemostatic agents were used more frequently (P<.0001). There were no differences in the number (P=.6) or severity (P=.47) of complications. The length of stay (P<.0001), the proportion of patients with drainage (P=.04) and the number of days with drainage (P=.0004) were lower in LESS. Twenty-five percent of the lesions operated on with LESS were benign, but the mean size was similar in the 2 groups (P=.5). Tumour recurrence and/or progression were more frequent in multiport laparoscopy (P=.0013). CONCLUSIONS: Umbilical LESS surgery with reusable platform enables various surgical techniques to be performed when treating renal masses, with time consumption and safety comparable to conventional laparoscopy. The LESS approach is advantageous in terms of blood loss and hospital stay.