1.
Bioorg Med Chem Lett
; 21(11): 3404-6, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21515054
RESUMEN
Heteroarylalanine derivatives 4 were designed as potential inhibitors of neutral endopeptidase (NEP EC 3.4.24.11). Selectivity over other zinc metalloproteinases was explored through occupation of the S2' subsite within NEP. Structural optimisation led to the identification of 5-phenyl oxazole 4f, a potent and selective NEP inhibitor. A crystal structure of the inhibitor bound complex is reported.