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J Dent Res ; 88(10): 910-5, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19783798

RESUMEN

A primary cilium, a sensory organelle present in almost every vertebrate cell, is regularly described in odontoblasts, projecting from the surfaces of the cells. Based on the hypothesis that the primary cilium is crucial both for dentin formation and possibly in tooth pain transmission, we have investigated the expression and localization of the main cilium components and involvement of the OFD1 gene in tooth morphogenesis. Odontoblasts in vitro express tubulin, inversin, rootletin, OFD1, BBS4, BBS6, ALMS1, KIF3A, PC1, and PC2. In vivo, cilia are aligned parallel to the dentin walls, with the top part oriented toward the pulp core. Close relationships between cilium and nerve fibers are evidenced. Calcium channels are concentrated in the vicinity of the basal body. Analysis of these data suggests a putative role of cilia in sensing the microenvironment, probably related to dentin secretion. This hypothesis is enhanced by the huge defects observed on molars from Ofd1 knockout mice, showing undifferentiated dentin-forming cells.


Asunto(s)
Cilios/fisiología , Proteínas de Choque Térmico/fisiología , Diente Molar/crecimiento & desarrollo , Odontoblastos/fisiología , Odontogénesis/fisiología , Adolescente , Animales , Canales de Calcio/análisis , Canales de Calcio/ultraestructura , Proteínas de Ciclo Celular , Movimiento Celular , Células Cultivadas , Proteínas del Citoesqueleto/análisis , Pulpa Dental/ultraestructura , Dentina/ultraestructura , Chaperoninas del Grupo II , Proteínas de Choque Térmico/análisis , Humanos , Cinesinas/análisis , Ratones , Ratones Noqueados , Proteínas Asociadas a Microtúbulos , Diente Molar/ultraestructura , Chaperonas Moleculares/análisis , Morfogénesis/fisiología , Fibras Nerviosas/ultraestructura , Proteínas/análisis , Canales Catiónicos TRPP/análisis , Factores de Transcripción/análisis , Tubulina (Proteína)/análisis
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