Estimation of the Prevalence of Occupational Exposure to Biological Fluids among Anesthesiologists: A Survey Study.

Background and Aims: Percutaneous injuries caused by sharps and exposure to biological fluids are a serious concern for anesthesiologists and pose a significant risk of transmission of blood-borne pathogens. Materials and Methods: The aim of this study was to estimate the prevalence of exposure to biological fluids among anesthesiologists. A questionnaire designed initially was validated after it was sent to 10 anesthesiologists with more than 5 years' experience. The validated questionnaire was then administered using Google Forms and the link was circulated electronically (e-mail, WhatsApp, and Telegram). This self-administered questionnaire was completed by 100 anesthesiologists. The various types and methods of body fluid years of exposure were also identified. Results: The prevalence of occupational exposure to body fluids was 100%. Exposure to either blood or cerebrospinal fluids by sharps was seen in 82%. Majority of the pricks were encountered during recapping of used needles followed by pricks during intravenous cannulation. Body fluid exposure onto the bare skin most frequently encountered was blood, mostly obtained during intravenous cannulation. There were 8% patients who had exposure to human immunodeficiency virus (HIV) and hepatitis B or C patients for which they had taken postexposure prophylaxis. Conclusion: Prevalence of exposure to biological fluids among anesthesiologists is alarmingly high. This poses a high risk for transmission of diseases. The use of protective gears and changing our casual attitude can prevent majority of the exposures. The practice of recapping of used needles should be stopped.

Stopping when knowing: use of snus and nicotine during pregnancy in Scandinavia.

In young women, the use of snus increases in parallel with decreasing smoking rates but the  use in pregnancy is unclear. Our aims were to determine the prevalence of snus use, smoking and other nicotine-containing product use during pregnancy, and to identify predictors for snus use in pregnancy. Prevalence was determined for 2528 women in Norway and Sweden based on the Preventing Atopic Dermatitis and ALLergies (PreventADALL) study, a population-based, mother-child birth cohort. Electronic questionnaires were completed in pregnancy week 18 and/or week 34, and potential predictors of snus use were analysed using logistic regression models. Ever use of any snus, tobacco or nicotine-containing products was reported by 35.7% of women, with similar rates of snus use (22.5%) and smoking (22.6%). Overall, 11.3% of women reported any use of nicotine-containing products in pregnancy up to 34 weeks, most often snus alone (6.5%). Most women (87.2%) stopped using snus by week 6 of pregnancy. Snus use in pregnancy was inversely associated with age and positively associated with urban living and personal or maternal history of smoking. While 11.3% of women used snus or other nicotine-containing products at some time, most stopped when recognising their pregnancy. Younger, urban living, previously smoking women were more likely to use snus in pregnancy.

Canine filarial infections in a human Brugia malayi endemic area of India.

A very high prevalence of microfilaremia of 42.68 per cent out of 164 canine blood samples examined was observed in Cherthala (of Alappuzha district of Kerala state), a known human Brugia malayi endemic area of south India. The species of canine microfilariae were identified as Dirofilaria repens, Brugia malayi, and Acanthocheilonema reconditum. D. repens was the most commonly detected species followed by B. pahangi. D. immitis was not detected in any of the samples examined. Based on molecular techniques, microfilariae with histochemical staining pattern of "local staining at anal pore and diffuse staining at central body" was identified as D. repens in addition to those showing acid phosphatase activity only at the anal pore. Even though B. malayi like acid phosphatase activity was observed in few dogs examined, they were identified as genetically closer to B. pahangi. Hence, the possibility of dogs acting as reservoirs of human B. malayi in this area was ruled out.

SU-E-T-649: Evaluation of RapidArc- Based Stereotactic Cranial Radiotherapy Plans with MU Objective Using Multiple Non Coplanar Arcs in Comparison with Conventional Dynamic Conformal Arc Technique.

PURPOSE: Previous researches reported that RapidArc plans for stereotactic cranial radiotherapy have two to three times more MUs as compared to Conventional Dynamic Conformal Arc (DCA) Technique. This study aims to evaluate RapidArc plans using multiple non- coplanar arcs, developed with MU objective constraint in the optimization stage. METHODS: Five single brain metastasis and three multiple metastases cases previously planned using DCA techniques in BrainLab iPlan Version 4.1 were investigated in this study. For each case, the target was defined on CT-MR fused images in iPlan. The CT images and contours of these patients were exported from iPlan to Varian Eclipse TPS Version 8.6. For each case, a DCA plan and a RapidArc plan with multiple non-coplanar arcs with and without using MU objective in the optimization stage were generated using Varian Trilogy machine with Millennium 120 MLC keeping the same prescription and critical structure dose limits. All plans were evaluated according to Conformity Index (CI-modified Paddick) Homogeneity Index (HI), and the normal tissue volume receiving various dose levels (V80%, V50%, V25% and V10%). RESULTS: In all the plans, the target objectives were met and dose to OARs was within tolerance dose constraints. RapidArc plans with and without MU objective showed better CI and HI as supposed to DCA plans. V80%, V50%, V25% and V10% of normal tissue for RapidArc plans are equal or lesser than DCA plans. Single isocentre RapidArc plan for closely spaced multiple metastases cases showed better dose fall off between the lesions as supposed to DCA plans. RapidArc plans with MU objective resulted in comparable MUs as that of DCA plans. CONCLUSIONS: Our study showed RapidArc plans done with and without MU objective have no significant dosimetric difference in plan objectives. Therefore, multiple non-coplanar RapidArc plans with MU objective is clinically feasible and can provide better treatment plans than conventional DCA plans, especially for complicated cases.