[Disorders of central hemodynamics and phase structure of left ventricle systole in patients with veratrine poisoning]. / Narusheniia tsentral'noi gemodinamiki i fazovoi struktury sistoly levogo zheludochka u bol'nykh s otravleniem veratrinom.

Central hemodynamics, phase structure of left ventricular systole, and circulating blood volume were studied in 56 patients with acute poisoning with veratrine. Two main variants of hemodynamic disorders were distinguished. Exposure of up to 3-4 hours led to bradycardia with heart rate of up to 47/min but no appreciable hemo- or cardiodynamic disorders. A longer exposure resulted in a decrease of the circulating blood volume, development of the phase syndrome of myocardial hypodynamia with a drop of stroke volume and cardiac output and development of hypotonia. These results indicate the necessity of a differentiated approach to the treatment of circulatory disorders in patients poisoned with veratrine.

[The functional status of the sinoatrial node and the atrioventricular conductivity in patients with acute klofelin poisoning]. / Funktsional'noe sostoianie sinoatrial'noi zony i atrioventrikuliarnoi provodimosti u bol'nykh s ostrym otravleniem klofelinom.

Using diagnostic transesophageal electrical cardiostimulation, sinus node function, sinoatrial and atrioventricular conductivity have been studied in 30 patients with acute clophelin poisoning. The results of pharmacological tests with atropine and alupent are presented. Control examinations have been performed on discharge. The results of pharmacological tests have shown that clophelin effect could be realized via imbalance of autonomous heart innervation. The technique of diagnostic transesophageal electrical cardiostimulation is recommended for wider use in clinical toxicology.

[Methodology of regional blood stabilization with sodium citrate during hemosorption and the first experience of its clinical application]. / Metodika regionarnoi stabilizatsii krovi tsitratom natriia pri gemosorbtsii i pervyi opyt ee klinicheskogo primeneniia.

The method of blood stabilization using sodium citrate ("Glugicir") has been elaborated. The experimental hemosorptions (HS) have shown that reliable blood stabilization in extracorporeal sorption contour was achieved with Glugicir/blood ratio 1 to 10, no considerable changes in the basic clearance characteristics of the sorbents have been observed. The method elaborated was used in 135 HS sessions performed in 100 patients. It has been shown that sodium citrate causes no changes in the patients' hemostasis. The method of regional blood stabilization with sodium citrate may be recommended for HS in patients with bleeding or high risk of its development. Mild symptoms of citrate intoxication (3.7%) were associated with technical inaccuracy and were easily eliminated either by discontinuation of excessive Glugicir introduction into the contour or by intravenous injection of calcium salts.