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Clin Transplant ; 35(1): e14150, 2021 01.
Artículo en Inglés | MEDLINE | ID: mdl-33170982

RESUMEN

There is uncertainty about the safety of kidney transplantation during the SARS-CoV-2 pandemic due to the risk of donor transmission, nosocomial infection and immunosuppression use. We describe organ donation and transplant practice in the UK and assess whether kidney transplantation conferred a substantial risk of harm. Data from the UK transplant registry were used to describe kidney donation and transplant activity in the UK, and a detailed analysis of short-term, single-center, patient results in two periods: during the pre-pandemic era from 30th December 2019 to 8th March 2020 ("Pre-COVID era") and the 9th March 2020 to 19th May 2020 ("COVID era"). Donor and recipient numbers fell by more than half in the COVID compared to the pre-COVID era in the UK, but there were more kidney transplants performed in our center (42 vs. 29 COVID vs. pre-COVID respectively). Overall outcomes, including re-operation, delayed graft function, primary non-function, acute rejection, length of stay and graft survival were similar between COVID and pre-COVID era. 6/71 patients became infected with SARS-CoV-2 but all were discharged without critical care requirement. Transplant outcomes have remained similar within the COVID period and no serious sequelae of SARS-CoV-2 infection were observed in the peri-transplant period.


Asunto(s)
COVID-19/complicaciones , Rechazo de Injerto/epidemiología , Hospitales de Alto Volumen/estadística & datos numéricos , Trasplante de Riñón/efectos adversos , SARS-CoV-2/aislamiento & purificación , Receptores de Trasplantes/estadística & datos numéricos , Adulto , COVID-19/inmunología , COVID-19/virología , Femenino , Rechazo de Injerto/inmunología , Rechazo de Injerto/virología , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Reino Unido/epidemiología
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