RESUMEN
Purpose: Glaucoma is the second leading cause of blindness worldwide, affecting more than 64 million people aged 40-80. The best way to manage primary open-angle glaucoma (POAG) is by lowering the intraocular pressure (IOP). Netarsudil is a Rho kinase inhibitor, the only class of antiglaucoma medications that reorganizes the extracellular matrix to improve the aqueous outflow through the trabecular pathway. Methods: An open-label, real-world, multicentric, observation-based 3-month study was performed for assessing the safety and ocular hypotensive efficacy of netarsudil ophthalmic solution (0.02% w/v) in patients with elevated IOP. Patients were given netarsudil ophthalmic solution (0.02% w/v) as a first-line therapy. Diurnal IOP measurements, best-corrected visual acuity, and adverse event assessments were recorded at each of the five visits (Day-1: screening day and first dosing day; subsequent observations were taken at 2 weeks, 4 weeks, 6 weeks, and 3 months). Results: Four hundred and sixty-nine patients from 39 centers throughout India completed the study. The mean IOP at baseline of the affected eyes was 24.84 ± 6.39 mmHg (mean ± standard deviation). After the first dose, the IOP was measured after 2, 4, and 6 weeks, with the final measurement taken at 3 months. The percentage reduction in IOP in glaucoma patients after 3 months of once-daily netarsudil 0.02% w/v solution use was 33.34%. The adverse effects experienced by patients were not severe in the majority of cases. Some adverse effects observed were redness, irritation, itching, and others, but only a small number of patients experienced severe reactions, as reported in a decreasing order: redness > irritation > watering > itching > stinging > blurring. Conclusion: We found that netarsudil 0.02% w/v solution monotherapy when used as the first-line treatment in primary open-angle glaucoma and ocular hypertension was both safe and effective.
Asunto(s)
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Glaucoma de Ángulo Abierto , Glaucoma , Hipertensión Ocular , Humanos , Soluciones Oftálmicas , Hipertensión Ocular/diagnóstico , Glaucoma/tratamiento farmacológico , Presión Intraocular , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/tratamiento farmacológico , Antihipertensivos/uso terapéutico , Resultado del TratamientoRESUMEN
Chikungunya fever is a relatively rare from of vector-borne viral fever caused by chikungunya virus and spread by bites of the Aedes aegypti and Aedes albopictus mosquito. Epidemics of chikungunya fever have been reported in the past from different parts of the world. Although the virus had been passive for quite some time, recent reports of outbreaks of chikungunya fever in several parts of Southern India have confirmed the re-emergence of this virus. Symptoms of this infection include abrupt onset of fever, chills, and headache, rash, severe joint pain, conjunctival injection and photophobia. Ocular manifestations have been recently reported with this infection. We report a case of a 48-year-old female patient, who presented with defective vision two weeks after a serology proven chikungunya infection. There was bilateral neuroretinitis with peripapillary cotton wool spots. These findings should be kept in mind as an ocular manifestation of chikungunya virus infection.
Asunto(s)
Infecciones por Alphavirus/virología , Virus Chikungunya/aislamiento & purificación , Infecciones Virales del Ojo/virología , Lateralidad Funcional , Neuritis Óptica/virología , Retinitis/virología , Infecciones por Alphavirus/diagnóstico , Infecciones por Alphavirus/tratamiento farmacológico , Anticuerpos Antivirales/sangre , Virus Chikungunya/genética , Virus Chikungunya/inmunología , Ensayo de Inmunoadsorción Enzimática , Infecciones Virales del Ojo/diagnóstico , Infecciones Virales del Ojo/tratamiento farmacológico , Femenino , Angiografía con Fluoresceína , Glucocorticoides/uso terapéutico , Humanos , Inmunoglobulina M/análisis , Persona de Mediana Edad , Neuritis Óptica/diagnóstico , Neuritis Óptica/tratamiento farmacológico , Reacción en Cadena de la Polimerasa , Prednisolona/uso terapéutico , ARN Viral/análisis , Retinitis/diagnóstico , Retinitis/tratamiento farmacológico , Agudeza VisualRESUMEN
We report a case of sudden loss of vision due to the development of acute myopia after the intake of chlorthalidone used for treating systemic hypertension. Clinically this was associated with ciliary spasm, shallow peripheral choroidal effusion and retinal striae at the macula with increase in macular thickness seen on optical coherence tomography. All these findings were reversed completely once the drug was discontinued. Development of acute myopia should be kept in mind as an adverse effect of a commonly used antihypertensive drug, namely chlorthalidone.
Asunto(s)
Clortalidona/efectos adversos , Diuréticos/efectos adversos , Miopía/inducido químicamente , Enfermedad Aguda , Adulto , Clortalidona/uso terapéutico , Diuréticos/uso terapéutico , Estudios de Seguimiento , Humanos , Hipertensión/tratamiento farmacológico , Masculino , Tomografía de Coherencia Óptica , Agudeza Visual/efectos de los fármacosRESUMEN
We describe an unusual case of periocular Dirofilariasis masquerading as a slow growing lid tumour in an elderly female patient.