Radical Resection for Locally Advanced Colon Cancer With Bladder Involvement Treated in a Tertiary Health Care Centre.

Colorectal cancer with involvement of the urinary bladder is infrequent in the nonmetastatic setting. Procedures for advanced colorectal cancers with bladder involvement may include partial or complete bladder resections. Proper therapeutic management principles dictate radical surgery when negative margins can be obtained. High-resolution CT imaging along with endoscopic evaluation of the urinary bladder is frequently required to assess the extent of urinary bladder dissection. Here, we present a case of adenocarcinoma of the sigmoid colon with urinary bladder involvement and its treatment.

Potential Neurologic Manifestations of COVID-19 Infection in Neonates.

In contrast to adults, neonates and infants with coronavirus disease 2019 (COVID-19) infection have milder symptoms and are less likely to require hospitalization. However, some neonates with COVID-19 can present with significant symptoms. Recent evidence suggests that neurologic manifestations of neonatal COVID-19 infection may be higher than initially thought. In this comprehensive review of the current literature, we summarize the clinical, laboratory, and radiologic findings, as well as potential management strategies for COVID-19-related neurologic illness in neonates. Although the growing brain may be affected by neurologic disease associated with COVID-19 infection, the few published studies on the long-term outcomes after COVID-19 infection in neonates and infants provide conflicting results. Larger collaborative clinical studies are needed to determine whether COVID-19 infection in neonates has long-term neurodevelopmental outcomes.

Comprehensive transcriptome analyses of Fusarium-infected root xylem tissues to decipher genes involved in chickpea wilt resistance.

Fusarium wilt is the most destructive soil-borne disease that poses a major threat to chickpea production. To comprehensively understand the interaction between chickpea and Fusarium oxysporum, the xylem-specific transcriptome analysis of wilt-resistant (WR315) and wilt-susceptible (JG62) genotypes at an early timepoint (4DPI) was investigated. Differential expression analysis showed that 1368 and 348 DEGs responded to pathogen infection in resistant and susceptible genotypes, respectively. Both genotypes showed transcriptional reprogramming in response to Foc2, but the responses in WR315 were more severe than in JG62. Results of the KEGG pathway analysis revealed that most of the DEGS in both genotypes with enrichment in metabolic pathways, secondary metabolite biosynthesis, plant hormone signal transduction, and carbon metabolism. Genes associated with defense-related metabolites synthesis such as thaumatin-like protein 1b, cysteine-rich receptor-like protein kinases, MLP-like proteins, polygalacturonase inhibitor 2-like, ethylene-responsive transcription factors, glycine-rich cell wall structural protein-like, beta-galactosidase-like, subtilisin-like protease, thioredoxin-like protein, chitin elicitor receptor kinase-like, proline transporter-like, non-specific lipid transfer protein and sugar transporter were mostly up-regulated in resistant as compared to susceptible genotypes. The results of this study provide disease resistance genes, which would be helpful in understanding the Foc resistance mechanism in chickpea. Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-023-03803-9.

Growth-defense trade-offs and yield loss in plants with engineered cell walls.

As a major component of plant secondary cell walls, lignin provides structural integrity and rigidity, and contributes to primary defense by providing a physical barrier to pathogen ingress. Genetic modification of lignin biosynthesis has been adopted to reduce the recalcitrance of lignified cell walls to improve biofuel production, tree pulping properties and forage digestibility. However, lignin-modification is often, but unpredictably, associated with dwarf phenotypes. Hypotheses suggested to explain this include: collapsed vessels leading to defects in water and solute transport; accumulation of molecule(s) that are inhibitory to plant growth or deficiency of metabolites that are critical for plant growth; activation of defense pathways linked to cell wall integrity sensing. However, there is still no commonly accepted underlying mechanism for the growth defects. Here, we discuss recent data on transcriptional reprogramming in plants with modified lignin content and their corresponding suppressor mutants, and evaluate growth-defense trade-offs as a factor underlying the growth phenotypes. New approaches will be necessary to estimate how gross changes in transcriptional reprogramming may quantitatively affect growth. Better understanding of the basis for yield drag following cell wall engineering is important for the biotechnological exploitation of plants as factories for fuels and chemicals.

Virtual screening,docking and molecular dynamics simulation of selected phytochemical compounds bound to receptor tyrosine kinases:A correlative anti angiogenic study.

Screening of phytochemicals for their anti angiogenic potential has been a growing area of research in the current decade. The following study proposes virtual screening, drug likeliness and ADME filtering of specific phytochemical based compounds retrieved from "TIP - A Database of Taiwan Indigenous Plants". The study further subjects the filtered phytochemicals for their molecular docking analysis and molecular dynamics simulation studies against the prominent receptor tyrosine kinases EGFR, VEGFR-1 and VEGFR-2 involved in angiogenesis phenomenon. Among the various in silico analysis done and precise interpretations, the current study finally proposes 1- Hydroxycryprochine as one of the most potent lead in combating angiogenic phenomenon and thus cancer. The following study involves all such important use of in silico platforms, tools and analysis protocols which are expected to reproduce commendable results in wet lab studies. The proposed compound 1-hydroxycryprochine tends to justify its anti angogenic potential in all interactional and stability studies.

Dynamical effects of breaking rotational symmetry in counter-rotating Stuart-Landau oscillators.

Stuart-Landau oscillators can be coupled so as to either preserve or destroy the rotational symmetry that the uncoupled system possesses. We examine some of the simplest cases of such couplings for a system of two nonidentical oscillators. When the coupling breaks the rotational invariance, there is a qualitative difference between oscillators wherein the phase velocity has the same sign (termed co-rotation) or opposite signs (termed counter-rotation). In the regime of oscillation death the relative sense of the phase rotations plays a major role. In particular, when rotational invariance is broken, counter-rotation or phase velocities of opposite signs appear to destabilize existing fixed points, thereby preserving and possibly extending the range of oscillatory behavior. The dynamical "frustration" induced by counter-rotations can thus suppress oscillation quenching when coupling breaks the symmetry.

Oscillation death and revival by coupling with damped harmonic oscillator.

Dynamics of nonlinear oscillators augmented with co- and counter-rotating linear damped harmonic oscillator is studied in detail. Depending upon the sense of rotation of augmenting system, the collective dynamics converges to either synchronized periodic behaviour or oscillation death. Multistability is observed when there is a transition from periodic state to oscillation death. In the periodic region, the system is found to be in mixed synchronization state, which is characterized by the newly defined "relative phase angle" between the different axes.

Using complementary approaches to identify trans-domain nuclear gene transfers in the extremophile Galdieria sulphuraria (Rhodophyta).

Identification of horizontal gene transfers (HGTs) has primarily relied on phylogenetic tree based methods, which require a rich sampling of sequenced genomes to ensure a reliable inference. Because the success of phylogenetic approaches depends on the breadth and depth of the database, researchers usually apply stringent filters to detect only the most likely gene transfers in the genomes of interest. One such study focused on a highly conservative estimate of trans-domain gene transfers in the extremophile eukaryote, Galdieria sulphuraria (Galdieri) Merola (Rhodophyta), by applying multiple filters in their phylogenetic pipeline. This led to the identification of 75 inter-domain acquisitions from Bacteria or Archaea. Because of the evolutionary, ecological, and potential biotechnological significance of foreign genes in algae, alternative approaches and pipelines complementing phylogenetics are needed for a more comprehensive assessment of HGT. We present here a novel pipeline that uncovered 17 novel foreign genes of prokaryotic origin in G. sulphuraria, results that are supported by multiple lines of evidence including composition-based, comparative data, and phylogenetics. These genes encode a variety of potentially adaptive functions, from metabolite transport to DNA repair.

Amplitude death phenomena in delay-coupled Hamiltonian systems.

Hamiltonian systems, when coupled via time-delayed interactions, do not remain conservative. In the uncoupled system, the motion can typically be periodic, quasiperiodic, or chaotic. This changes drastically when delay coupling is introduced since now attractors can be created in the phase space. In particular, for sufficiently strong coupling there can be amplitude death (AD), namely, the stabilization of point attractors and the cessation of oscillatory motion. The approach to the state of AD or oscillation death is also accompanied by a phase flip in the transient dynamics. A discussion and analysis of the phenomenology is made through an application to the specific cases of harmonic as well as anharmonic coupled oscillators, in particular the Hénon-Heiles system.

Dynamical effects of integrative time-delay coupling.

We study coupled dynamical systems wherein the influence of one system on the other is cumulative: coupling signals are integrated over a time interval τ. A major consequence of integrative coupling is that amplitude death occurs over a wider range and in a single region in parameter space. For coupled limit cycle oscillators (the Landau-Stuart model) we obtain an analytic estimate for the boundary of this region while for coupled chaotic Lorenz oscillators numerical results are presented. For given τ we find that there is a critical coupling strength at which the frequency of oscillations changes discontinuously.