RESUMEN
Knowledge about the influence of salt water baths on UV irradiation, especially balneophototherapy, is incomplete. The aim of this study was to investigate the influence of various concentrated salt solutions on the minimal erythema dose (MED). We determined the MEDdry (UVB) in 24 healthy, previously UV unexposed subjects on the inner forearm. Subjects were divided randomly into two groups of 12. Subsequently, the MEDwet was assessed on each forearm after 30 min tap water or 5% salt water bath (group A), respectively, or after 30 min 10% or 20% salt water bath (group B), respectively. Compared with the MEDdry, a significantly decreased MEDwet, was observed after all exposures (group A==>F = 18.94; P < 0.001; group B==>F = 11.73; P < 0.006). A maximal relative decrease in MEDdry of about 51.4% was observed after the 10% salt water bath. The 5% salt solution caused a modest relative decrease in MEDwet of 23.4%. We observed a markedly increased photosensitivity to UVB after all exposures, without a linear correlation between the MED and the salt water concentration. A determination of MED during balneophototherapy should be carried out after bathing in order to reduce the cumulative UV dose and to prevent acute photodamage.
Asunto(s)
Baños , Eritema/terapia , Piel/efectos de la radiación , Cloruro de Sodio/administración & dosificación , Rayos Ultravioleta , Adulto , Eritema/etiología , Eritema/patología , Femenino , HumanosRESUMEN
Discussion of etiologically important facts in urticaria dealing as well with allergy as with psychosomatic origin.
Asunto(s)
Dermatitis Atópica/etiología , Urticaria/etiología , Diagnóstico Diferencial , Humanos , Urticaria/psicologíaRESUMEN
We report on the clinical efficacy of the local corticoid prednicarbate (chemical name: prednisolone-17-ethyl carbonate-21-propionate). In a concentration of 0.25%, it can be assigned to corticoid force class III. We think it's remarkable that even extensive application of 20 g daily in patients with affected skin and 30 g daily in healthy persons does not cause any suppression of plasma cortisol. Extreme long-term application (12 months) in 4 test persons did not result in any clinical, histological, or electron microscopical signs of topical atrophy; only one case showed slight hypertrichosis. These studies show that we may regard the original opinion as disproved that efficacy and side effects of corticoids are always inseparably linked together. To our minds, this preparation constitutes an essential step towards solving the problem of long-term application of a topical corticoid wherever it may be necessary from the dermatologic point of view, e.g. especially in atopic dermatitis and psoriasis.
Asunto(s)
Antiinflamatorios/uso terapéutico , Dermatitis/tratamiento farmacológico , Prednisolona/análogos & derivados , Administración Tópica , Adolescente , Adulto , Anciano , Valerato de Betametasona/uso terapéutico , Niño , Cortisona/análogos & derivados , Cortisona/uso terapéutico , Dermatitis Atópica/tratamiento farmacológico , Dermatitis por Contacto/tratamiento farmacológico , Desoximetasona/uso terapéutico , Método Doble Ciego , Evaluación de Medicamentos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prednisolona/uso terapéutico , Psoriasis/tratamiento farmacológicoAsunto(s)
Antiinflamatorios/administración & dosificación , Pregnenodionas/administración & dosificación , Psoriasis/tratamiento farmacológico , Administración Tópica , Budesonida , Fenómenos Químicos , Química , Ensayos Clínicos como Asunto , Método Doble Ciego , Glucocorticoides , Humanos , Distribución AleatoriaRESUMEN
The problems of nonallergic chronic urticaria (nonallergic urticaria syndrome) is presented in detail. The course and the special diagnostic requirements are discussed in detail. Then a model of the diagnostic strategy in chronic urticaria is presented and discussed. It is particularly emphasized that in the overwhelming majority of nonallergic syndrome patients, psychic problems are predominant and that correct specialist treatment is followed by freedom from symptoms in very many cases.