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We report measurements of electron densities, n_{e}, and temperatures, T_{e}, in a magnetized expanding hydrogen plasma performed using Thomson scattering. The effects of applying an axial magnetic field and changing the background pressure in the plasma vessel on n_{e} and T_{e} along the expansion axis are reported. Magnetic field strengths (B field) up to 170 mT were applied, which are one order of magnitude larger than previously reported. The main effect of the applied B field is the plasma confinement, which leads to higher n_{e}. At B fields larger than 88 mT the electron density along the expansion axis does not depend strongly on the magnetic field strength. However, T_{e} is susceptible to the B field and reaches at 170 mT a maximum of 2.5 eV at a distance of 1.5 cm from the exit of the cascaded arc. To determine also the effect of the arc current through the arc, measurements were performed with arc currents of 45, 60, and 75 A at background pressures of 9.7 and 88.3 Pa. At constant magnetic field n_{e} decreases from the exit of the arc along the expansion axis when the arc current is decreased. At 88.3 Pa n_{e} shows a higher value close to the exit of the arc, but a faster decay along the expansion axis with respect to the 9.7 Pa case. T_{e} is overall higher at lower pressure reaching a maximum of 3.2 eV at the lower arc current of 45 A. The results of this study complement our understanding and the characterization of expanding hydrogen plasmas.
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An advanced Thomson scattering system has been built for a linear plasma generator for plasma surface interaction studies. The Thomson scattering system is based on a Nd:YAG laser operating at the second harmonic and a detection branch featuring a high etendue (f/3) transmission grating spectrometer equipped with an intensified charged coupled device camera. The system is able to measure electron density (n(e)) and temperature (T(e)) profiles close to the output of the plasma source and, at a distance of 1.25 m, just in front of a target. The detection system enables to measure 50 spatial channels of about 2 mm each, along a laser chord of 95 mm. By summing a total of 30 laser pulses (0.6 J, 10 Hz), an observational error of 3% in n(e) and 6% in T(e) (at n(e) = 9.4 × 10(18) m(-3)) can be obtained. Single pulse Thomson scattering measurements can be performed with the same accuracy for n(e) > 2.8 × 10(20) m(-3). The minimum measurable density and temperature are n(e) < 1 × 10(17) m(-3) and T(e) < 0.07 eV, respectively. In addition, using the Rayleigh peak, superimposed on the Thomson scattered spectrum, the neutral density (n(0)) of the plasma can be measured with an accuracy of 25% (at n(0) = 1 × 10(20) m(-3)). In this report, the performance of the Thomson scattering system will be shown along with unprecedented accurate Thomson-Rayleigh scattering measurements on a low-temperature argon plasma expansion into a low-pressure background.
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Ion and neutral parameters are determined in the high electron density, magnetized, hydrogen plasma beam of an ITER divertor relevant plasma via measurements of the n=2 excited neutrals. Ion rotation velocity (up to 7 km/s) and temperature (2-3 eV~T_{e}) are obtained from analysis of Hα spectra measured close to the plasma source. The methodology for neutral density determination is explained whereby measurements in the linear plasma beam of Pilot-PSI are compared to modeling. Ground-state atomic densities are obtained via the production rate of n=2 and the optical thickness of the Lyman-α transition (escape factor ~0.6) and yield an ionization degree >85% and dissociation degree in the residual gas of ~4%. A 30% proportion of molecules with a rovibrational excitation of more than 2 eV is deduced from the production rate of n=2 atoms. This proportion increases by more than a factor of 4 for a doubling of the electron density in the transition to ITER divertor relevant electron densities, probably because of a large increase in the production and confinement of ground-state neutrals. Measurements are made using laser-induced fluorescence (LIF) and absorption, the suitability of which are evaluated as diagnostics for this plasma regime. Absorption is found to have a much better sensitivity than LIF, mainly owing to competition with background emission.
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A weakly magnetized expanding hydrogen plasma, created by a cascaded arc, was investigated using optical emission spectroscopy. The emission of the expanding plasma is dominated by H{α} emission in the first part of the plasma expansion, after which a sharp transition to a blue afterglow is observed. The position of this sharp transition along the expansion axis depends on the magnetic field strength. The blue afterglow emission is associated with population inversion of the electronically excited atomic hydrogen states n=4-6 with respect to n=3. By comparing the measured densities with the densities using an atomic collisional radiative model, we conclude that atomic recombination processes cannot account for the large population densities observed. Therefore, molecular processes must be important for the formation of excited states and for the occurrence of population inversion. This is further corroborated at the transition from red to blue, where a hollow profile of the excited states n=4-6 in the radial direction is observed. This hollow profile is explained by the molecular mutual neutralization process of H2+ with Hâ», which has a maximum production for excited atomic hydrogen 1-2 cm outside the plasma center.
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State resolved densities of high rovibrationally excited hydrogen isotopologues H(2), HD, and D(2) in the electronic ground state have been measured in a supersonically expanding plasma jet. The obtained state distributions differ substantially from thermal equilibrium. Moreover, the distributions are not the same for H(2), HD, and D(2) indicating different formation and relaxation rates for each isotopologue. Mechanisms for this deviation from a Boltzmann distribution are given and compared to hydrogen reactions in other environments. The difference between the measured highest occupied rovibrational states in H(2), HD, and D(2) is ascribed to an isotope effect in the dissociation process.
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A potential buildup in front of a magnetized cascaded arc hydrogen plasma source is explored via E x B rotation and plate potential measurements. Plasma rotation approaches thermal speeds with maximum velocities of 10 km/s. The diagnostic for plasma rotation is optical emission spectroscopy on the Balmer-beta line. Asymmetric spectra are observed. A detailed consideration is given on the interpretation of such spectra with a two distribution model. This consideration includes radial dependence of emission determined by Abel inversion of the lateral intensity profile. Spectrum analysis is performed considering Doppler shift, Doppler broadening, Stark broadening, and Stark splitting.
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We report on the interaction of hydrogen atoms and molecules under high flux conditions with a cooled copper surface and its impact on gas phase densities and internal excitation of the molecules. These densities were measured by means of laser-induced fluorescence using tunable radiation sources in the vacuum-ultraviolet (vuv). While H atoms were detected by two-photon absorption laser-induced fluorescence, the necessary vuv radiation for the detection of rovibrationally excited H2 molecules in the electronic ground state were produced by stimulated anti-Stokes Raman scattering. The results reveal a strong loss mechanism of H atoms and the formation of rovibrationally excited H2 molecules due to surface interaction. The surface reaction probability of H atoms under high flux conditions on copper was estimated. Surface collisions are shown to have a profound influence on the density distribution of rovibrationally excited H2 molecules: The distributions follow lower temperatures and are less Boltzmann-like, i.e., the distributions of the internal excitation of H2 molecules differ more from thermodynamic equilibrium.
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The gas dynamics of a stationary hot-gas jet supersonically expanding into a low pressure environment is studied through numerical simulations. A hybrid coupled continuum-molecular approach is used to model the flow field. Due to the low pressure and high thermodynamic gradients, continuum mechanics results are doubtful, while, because of its excessive time expenses, a full molecular method is not feasible. The results of the hybrid coupled continuum-molecular approach proposed have been successfully validated against experimental data by R. Engeln [Plasma Sources Sci. Technol. 10, 595 (2001)] obtained by means of laser induced fluorescence. Two main questions are addressed: the necessity of applying a molecular approach where rarefaction effects are present in order to correctly model the flow and the demonstration of an invasion of the supersonic part of the flow by background particles. A comparison between the hybrid method and full continuum simulations demonstrates the inadequacy of the latter, due to the influence of rarefaction effects on both velocity and temperature fields. An analysis of the particle velocity distribution in the expansion-shock region shows clear departure from thermodynamic equilibrium and confirms the invasion of the supersonic part of the flow by background particles. A study made through particles and collisions tracking in the supersonic region further proves the presence of background particles in this region and explains how they cause thermodynamic nonequilibrium by colliding and interacting with the local particles.
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A highly sensitive imaging Thomson scattering system was developed for low temperature (0.1-10 eV) plasma applications at the Pilot-PSI linear plasma generator. The essential parts of the diagnostic are a neodymium doped yttrium aluminum garnet laser operating at the second harmonic (532 nm), a laser beam line with a unique stray light suppression system and a detection branch consisting of a Littrow spectrometer equipped with an efficient detector based on a "Generation III" image intensifier combined with an intensified charged coupled device camera. The system is capable of measuring electron density and temperature profiles of a plasma column of 30 mm in diameter with a spatial resolution of 0.6 mm and an observational error of 3% in the electron density (n(e)) and 6% in the electron temperature (T(e)) at n(e) = 4 x 10(19) m(-3). This is achievable at an accumulated laser input energy of 11 J (from 30 laser pulses at 10 Hz repetition frequency). The stray light contribution is below 9 x 10(17) m(-3) in electron density equivalents by the application of a unique stray light suppression system. The amount of laser energy that is required for a n(e) and T(e) measurement is 7 x 10(20)n(e) J, which means that single shot measurements are possible for n(e)>2 x 10(21) m(-3).
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We measured the densities of NH and NH(2) radicals by cavity ring-down spectroscopy in N(2)-H(2) plasmas expanding from a remote thermal plasma source and in N(2) plasmas to which H(2) was added in the background. The NH radical was observed via transitions in the (0,0), (1,1), and (2,2) vibrational bands of the A(3)Pi <-- X(3)Sigma- electronic transition and the NH(2) radical via transitions in the (0,9,0) <-- (0,0,0) band of the A(2)A(1) <-- X(2)B(1) electronic transition. The measurements revealed typical densities of 5 x 10(18) m(-3) for the NH radical in both plasmas and up to 7 x 10(18) m(-3) for the NH(2) radical when N(2) and H(2) are both fed through the plasma source. In N(2) plasma with H(2) injected in the background, no NH(2) was detected, indicating that the density is below our detection limit of 3 x 1016 m-3. The error in the measured densities is estimated to be around 20%. From the trends of the NH(x) radicals as a function of the relative H(2) flow to the total N(2) and H(2) flow at several positions in the expanding plasma beam, the key reactions for the formation of NH and NH(2) have been determined. The NH radicals are mainly produced via the reaction of N atoms emitted by the plasma source with H(2) molecules with a minor contribution from the reaction of N+ with H(2). The NH(2) radicals are formed by reactions of NH(3) molecules, produced at the walls of the plasma reactor, and H atoms emitted by the plasma source. The NH radicals can also be produced by H abstraction of NH(2) radicals. The flux densities of the NH(x) radicals with respect to the atomic radicals are appreciable in the first part of the expansion. Further downstream the NH(x) radicals are dissociated, and their densities become smaller than those of the atomic radicals. It is concluded that the NH(x) radicals play an important role as precursors for the N and H atoms, which are key to the surface production of N(2), H(2), and NH(3) molecules.
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BACKGROUND: The prevalence of allergic diseases has increased rapidly in recent decades, particularly in children. For adequate prevention it is important not only to identify risk factors, but also possible protective factors. The aim of this study was to compare the prevalence of allergic diseases and sensitization between farm children, children in anthroposophic families, and reference children, with the aim to identify factors that may protect against allergic disease. METHODS: The study was of cross-sectional design and included 14,893 children, aged 5-13 years, from farm families, anthroposophic families (recruited from Steiner schools) and reference children in Austria, Germany, The Netherlands, Sweden and Switzerland. A detailed questionnaire was completed and allergen-specific IgE was measured in blood. RESULTS: Growing up on a farm was found to have a protective effect against all outcomes studied, both self-reported, such as rhinoconjunctivitis, wheezing, atopic eczema and asthma and sensitization (allergen specific IgE > or = 0.35 kU/l). The adjusted odds ratio (OR) for current rhinoconjunctivitis symptoms was 0.50 (95% confidence interval (CI) 0.38-0.65) and for atopic sensitization 0.53 (95% CI 0.42-0.67) for the farm children compared to their references. The prevalence of allergic symptoms and sensitization was also lower among Steiner school children compared to reference children, but the difference was less pronounced and not as consistent between countries, adjusted OR for current rhinoconjunctivitis symptoms was 0.69 (95% CI 0.56-0.86) and for atopic sensitization 0.73 (95% CI 0.58-0.92). CONCLUSIONS: This study indicates that growing up on a farm, and to a lesser extent leading an anthroposophic life style may confer protection from both sensitization and allergic diseases in childhood.
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Agricultura , Medicina Antroposófica , Hipersensibilidad/prevención & control , Estilo de Vida , Adolescente , Niño , Preescolar , Conjuntivitis/prevención & control , Estudios Transversales , Femenino , Humanos , Hipersensibilidad/epidemiología , Masculino , Oportunidad Relativa , Prevalencia , Rinitis/prevención & controlRESUMEN
BACKGROUND: In most epidemiological surveys the estimated prevalence of asthma is based on questionnaire responses, which may depend on the individual's perception as well as medical consulting habits in a given population. Therefore, measurement of bronchial hyper-responsiveness as a key feature of asthma has been suggested as an objective parameter for asthma. OBJECTIVE: The aim of the present study was to validate questionnaire responses on asthma and wheeze against bronchial response to hypertonic saline (HS) (4.5%) in populations previously shown to have a lower prevalence of asthma and allergies: farmers' children and children from anthroposophic families. METHODS: Children whose parents had completed a written questionnaire in the cross-sectional PARSIFAL-study were drawn from the following four subgroups: 'farm children' (n=183), 'farm reference children' (n=173), 'Steiner schoolchildren' (n=243) and 'Steiner reference children' (n=179). Overall, 319 children with wheeze in the last 12 months and 459 children without wheeze in the last 12 months performed an HS challenge. RESULTS: Odds ratios, sensitivity, specificity, likelihood ratios and measures of association did not differ significantly between the four subgroups. The correlation between the bronchial response to HS and wheeze and asthma questions was moderate and similar for farm children, farm reference children, Steiner schoolchildren and Steiner reference children (kappa for 'wheeze': 0.25, 0.33, 0.31, 0.35, respectively, P=0.754, kappa for 'doctor's diagnosis of asthma': 0.33, 0.19, 0.33, 032, respectively, P=0.499). CONCLUSION: The findings from this study suggest that the reliabilitiy of questionnaire responses on asthma and wheeze is comparable between farmers' children, children raised in families with anthroposophic lifestyle and their respective peers.
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Asma/diagnóstico , Ruidos Respiratorios/diagnóstico , Adolescente , Medicina Antroposófica , Asma/inmunología , Pruebas de Provocación Bronquial , Niño , Femenino , Volumen Espiratorio Forzado/inmunología , Humanos , Masculino , Reproducibilidad de los Resultados , Ruidos Respiratorios/inmunología , Salud Rural , Solución Salina Hipertónica , Sensibilidad y Especificidad , Encuestas y CuestionariosRESUMEN
BACKGROUND: Growing up on a farm and an anthroposophic lifestyle are associated with a lower prevalence of allergic diseases in childhood. It has been suggested that the enhanced exposure to endotoxin is an important protective factor of farm environments. Little is known about exposure to other microbial components on farms and exposure in anthroposophic families. OBJECTIVE: To assess the levels and determinants of bacterial endotoxin, mould beta(1,3)-glucans and fungal extracellular polysaccharides (EPS) in house dust of farm children, Steiner school children and reference children. METHODS: Mattress and living room dust was collected in the homes of 229 farm children, 122 Steiner children and 60 and 67 of their respective reference children in five European countries. Stable dust was collected as well. All samples were analysed in one central laboratory. Determinants were assessed by questionnaire. RESULTS: Levels of endotoxin, EPS and glucans per gram of house dust in farm homes were 1.2- to 3.2-fold higher than levels in reference homes. For Steiner children, 1.1- to 1.6-fold higher levels were observed compared with their reference children. These differences were consistently found across countries, although mean levels varied considerably. Differences between groups and between countries were also significant after adjustment for home and family characteristics. CONCLUSION: Farm children are not only consistently exposed to higher levels of endotoxin, but also to higher levels of mould components. Steiner school children may also be exposed to higher levels of microbial agents, but differences with reference children are much less pronounced than for farm children. Further analyses are, however, required to assess the association between exposure to these various microbial agents and allergic and airway diseases in the PARSIFAL population.
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Agricultura , Polvo/análisis , Endotoxinas/análisis , Estructuras Fúngicas/aislamiento & purificación , Estilo de Vida , Instituciones Académicas , Niño , Estudios Transversales , Europa (Continente) , Líquido Extracelular/química , Humanos , Análisis Multivariante , Polisacáridos/análisis , beta-Glucanos/análisisRESUMEN
Acetylene chemistry is studied by means of threshold ionization mass spectrometry (TIMS) in remote Ar/C(2)H(2) expanding thermal plasma to identify the growth precursors of hydrogenated amorphous carbon (a-C:H) films. More than 20 hydrocarbon species are measured, enabling a comprehensive study of acetylene chemistry in the plasma environment. It is shown that the plasma composition is controlled by the initial ratio between the acetylene flow into the reactor and argon ion and electron fluence emanating from the remote plasma source. Complete decomposition of acetylene to C, CH, CH(2), C(2), and C(2)H radicals is achieved in subsequent charge transfer and dissociative recombination reactions under low acetylene flow conditions. The formation of soft polymer-like a-C:H films can be attributed to C, C(2), and also partially to CH and C(2)H deposition. At acetylene flows higher than argon ion and electron fluence, reactions of C, CH, C(2), and C(2)H radicals with acetylene lead to the formation of various hydrocarbon species, whose behavior is dependent on whether the number of carbon atoms is even or odd. The detected resonantly stabilized C(3), C(3)H, and probably also C(5) and C(5)H radicals are unreactive with acetylene in the gas phase and are, therefore, abundantly present close to the substrate. The C(3) radical has among them the highest density, and it is identified as the significant growth precursor of Ar/C(2)H(2) expanding thermal plasma deposited hard a-C:H films.
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The evolution of the rotational and vibrational distributions of molecular hydrogen in a hydrogen plasma expansion is measured using laser induced fluorescence in the vacuum-UV range. The evolution of the distributions along the expansion axis shows the relaxation of the molecular hydrogen from the high temperature in the upstream region to the low ambient temperature in the downstream region. During the relaxation, the vibrational distribution, which has been recorded up to v = 6, is almost frozen in the expansion and resembles a Boltzmann distribution at T approximately 2200 K. However, the rotational distributions, which have been recorded up to J = 17 in v = 2 and up to J = 11 in v = 3, cannot be described with a single Boltzmann distribution. In the course of the expansion, the lower rotational levels (J < 5) adapt quickly to the ambient temperature ( approximately 500 K), while the distribution of the higher rotational levels (J > 7) is measured to be frozen in the expansion at a temperature between 2000 and 2500 K. A model based on rotation-translation energy transfer is used to describe the evolution of the rotational distribution of vibrational level v = 2 in the plasma expansion. The behavior of the low rotational levels (J < 5) is described satisfactory. However, the densities of the higher rotational levels decay faster than predicted.
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The evolution of the ground-state hydrogen atom velocity distribution function throughout the stationary shock wave of a supersonic hydrogen plasma jet (3
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The transport of ground-state atomic hydrogen in the expansion of a thermal plasma generated from an Ar-H2 mixture is studied by means of laser-based diagnostic techniques. The flow of hydrogen atoms is investigated by two-photon excitation laser-induced fluorescence (LIF), whereas Ar atoms are probed by LIF as well as by UV Rayleigh scattering. The transport of Ar atoms can be fully understood in terms of a free jet flow; H atoms on the contrary exhibit an anomalous behavior. In the course of the plasma expansion, hydrogen atoms decouple from the argon fluid by a diffusion process as a direct consequence of recombination of H atoms at the vessel walls. In this contribution it is shown, on the basis of experimental results, how plasma-surface interactions can strongly influence the flow pattern of an atomic radical fluid.
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We conducted the study described in this paper to investigate the impact of ambient temperature on mortality in the Netherlands during 1979-1997, the impact of heat waves and cold spells on mortality in particular, and the possibility of any heat wave- or cold spell-induced forward displacement of mortality. We found a V-like relationship between mortality and temperature, with an optimum temperature value (e.g., average temperature with lowest mortality rate) of 16.5 degrees C for total mortality, cardiovascular mortality, respiratory mortality, and mortality among those [Greater and equal to] 65 year of age. For mortality due to malignant neoplasms and mortality in the youngest age group, the optimum temperatures were 15.5 degrees C and 14.5 degrees C, respectively. For temperatures above the optimum, mortality increased by 0.47, 1.86, 12.82, and 2.72% for malignant neoplasms, cardiovascular disease, respiratory diseases, and total mortality, respectively, for each degree Celsius increase above the optimum in the preceding month. For temperatures below the optimum, mortality increased 0.22, 1.69, 5.15, and 1.37%, respectively, for each degree Celsius decrease below the optimum in the preceding month. Mortality increased significantly during all of the heat waves studied, and the elderly were most effected by extreme heat. The heat waves led to increases in mortality due to all of the selected causes, especially respiratory mortality. Average total excess mortality during the heat waves studied was 12.1%, or 39.8 deaths/day. The average excess mortality during the cold spells was 12.8% or 46.6 deaths/day, which was mostly attributable to the increase in cardiovascular mortality and mortality among the elderly. The results concerning the forward displacement of deaths due to heat waves were not conclusive. We found no cold-induced forward displacement of deaths.
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Frío/efectos adversos , Calor/efectos adversos , Mortalidad , Adolescente , Adulto , Factores de Edad , Anciano , Enfermedades Cardiovasculares/mortalidad , Causas de Muerte , Niño , Preescolar , Clima , Trastornos de Estrés por Calor/epidemiología , Trastornos de Estrés por Calor/mortalidad , Humanos , Lactante , Persona de Mediana Edad , Neoplasias/mortalidad , Países Bajos/epidemiología , Análisis de Regresión , Enfermedades Respiratorias/mortalidad , TemperaturaRESUMEN
This case report documents an uncommon cause of bilateral diaphragmatic paralysis resulting from phrenic nerve injury during cervical chiropractic manipulation. Several months after the initial injury, our patient remains short of breath and has difficulty breathing in the supine position. Other causes of diaphragmatic paralysis and phrenic nerve injury are reviewed.
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Manipulación Espinal/efectos adversos , Parálisis Respiratoria/etiología , Adulto , Humanos , Masculino , Parálisis Respiratoria/diagnósticoRESUMEN
Previously, we demonstrated that avian vascular smooth muscle cells (VSMC) derived from embryonic abdominal and thoracic aorta grow differently in the presence of transforming growth factor beta (TGF-beta1) and platelet-derived growth factor (PDGF-BB) (Wrenn et al., In Vitro Cell. Dev. Biol. 29, 73-78, 1992). The thoracic VSMC (N-VSMC) are derived from neural crest, and therefore differentiate from ectoderm; the abdominal VSMC (M-VSMC) are derived from mesoderm. The present study was designed to identify factors that mediate the differential responses of the VSMC to TGF-beta1. We found that TGF-beta1 increased DNA synthesis by approximately sevenfold in N-VSMC. Levels of both alpha1 (I) procollagen and c-myb mRNAs were markedly induced in N-VSMC treated with TGF-beta1. Chimeric plasmids containing up to 3.5 kb of alpha1 (I) procollagen 5' flanking DNA were induced to equivalent levels as procollagen mRNA in N-VSMC. However, TGF-beta1 increased DNA synthesis by threefold in M-VSMC; there was no effect on alpha1 (I) procollagen expression, and c-myb was not expressed, as demonstrated by immunohistochemistry staining and RNA analyses. Antisense c-myb oligodeoxynucleotides blocked the TGF-beta1 induction of alpha1 (I) procollagen and the growth of N-VSMC. The increase in DNA synthesis by M- and N-VSMC was correlated with the secretion of PDGF-AA, and staurosporine and antibodies directed against PDGF-AA suppressed DNA synthesis. Our results demonstrate that TGF-beta1 activity and c-myb expression modulate the expression of alpha1 (I) collagen and cell proliferation in neural crest-derived smooth muscle. The regulation of these events by TGF-beta1 may be important during morphogenesis of blood vessels and vascular diseases.