Current treatment strategies for primary upper extremity deep venous thrombosis; a retrospective observational multicenter case series.

Introduction: Current treatment strategies for primary upper extremity deep venous thrombosis (pUEDVT) range from conservative treatment with anticoagulation therapy to invasive treatment with thoracic outlet decompression surgery (TOD), frequently combined with catheter directed thrombolysis, percutaneous transluminal angioplasty, or stenting. Due to a lack of large prospective series with uniform data collection or a randomized trial, the optimal treatment strategy is still under debate. We conducted a multicenter observational study to assess the efficacy and safety of both the conservative and invasive treatment strategies for patients with pUEDVT. Methods: We retrospectively collected data from patients treated in five vascular referral and teaching hospitals in the Netherlands between 2008 and 2019. Patients were divided into a conservative (Group 1), an invasive treatment group (Group 2) and a cross-over group (Group 3) of patients who received surgical treatment after initial conservative therapy. Follow-up consisted of outpatient clinic visits and an electronic survey. Primary outcome was symptom free survival defined as absence of any symptom of the affected arm reported at last follow-up regardless of severity, or extent of functional disability. Secondary outcomes were incidence of bleeding complications, recurrent venous thromboembolism, surgical complications, and reinterventions. Results: A total of 115 patients were included (group 1 (N = 45), group 2 (N = 53) or group 3 (N = 27). The symptom free survival was 35.6%, 54.7% and 48.1% after a median follow-up of 36, 26 and 22 months in groups 1, 2 and 3 respectively. Incidence of bleeding complications was 8.6%, 3.8% and 18.5% and recurrent thrombosis occurred in 15.6%, 13.2% and 14.8% in groups 1-3 respectively. Conclusion: In this multicenter retrospective observational cohort analysis the conservative and direct invasive treatments for pUEDVT were deemed safe with low percentages of bleeding complications. Symptom free survival was highest in the direct surgical treatment group but still modest in all subgroups. Perioperative complications were infrequent with no related long term morbidity. Of relevance, pUEDVT patients with confirmed VTOS and recurrent symptoms after conservative treatment may still benefit from TOD surgery. However, symptom free survival of this delayed TOD seems lower than direct surgical treatment and bleeding complications seem to occur more frequently.

Mandibular canal-related parameters interpreted in panoramic images and CBCT of mandibular third molars as risk factors to predict sensory disturbances of the inferior alveolar nerve.

The aim of this study was to determine whether cone beam computed tomography (CBCT) before mandibular third molar removal can improve the risk assessment for neurosensory disturbances of the inferior alveolar nerve (IAN) compared to panoramic radiography (PAN). One hundred and six mandibular third molars examined by PAN and CBCT were removed. A temporary sensory disturbance of the IAN was present in 20 cases; a permanent disturbance was found in one case. Three blinded observers assessed radiographic risk factors in PAN and CBCT images. Positive (PPV) and negative (NPV) predictive values and positive (LR+) and negative (LR-) likelihood ratios were calculated for all parameters for all observers. Inter-observer reproducibility was expressed as both the percentage accordance and the kappa-statistic. Generally, the PPV and LR + were the same for PAN and CBCT, and there was good inter-observer reproducibility. The highest PPV and LR + for PAN were found when part of the roots were positioned inferior to the lower white border line of the canal, and for CBCT when the canal was positioned between the roots of the tooth. In conclusion, parameters assessed in PAN and CBCT are not reliable risk factors for neurosensory disturbances of the IAN, and CBCT appears not to improve the risk assessment.

Radiographic observers' ability to recognize patient movement during cone beam CT.

OBJECTIVES: To assess radiographic observers' ability to recognize patient movement during cone beam CT and to decide early termination of the examination. METHODS: 100 patients were video-recorded during cone beam CT examination. Patients' videos were cropped twice: fitting the active 20-s examination time or the initial non-radiation 3 s of the examination. x- and y-coordinates of pre-defined points marked on the patient's face were used to define the reference standard for movement in the 20-s videos. A sample of 40 non-moving and 20 moving patients was selected. Eight observers scored the videos. The 3-s videos were scored: 0, the patient did not move; 1, the patient moved and the examination should be terminated. The 20-s videos were scored: 0, the patient did not move; 1, the patient moved. Re-assessment of 15% of the videos provided intra-observer reproducibility. The 20-s videos were compared with the reference standard providing sensitivity and specificity values (movement/non-movement recognition). The scores of the 3-s videos were compared with the scores of the 20-s videos. RESULTS: Intra- and interobserver reproducibility ranged from substantial to almost perfect for both videos. The 20-s videos allowed patient movement recognition with a high specificity and a medium to high sensitivity. The 3-s videos allowed early termination of the examination with a small number of incorrect positive scores. The majority of the patients scored as moving in the 20-s videos were detected in the 3-s videos. CONCLUSIONS: By observing video recordings, trained observers are able to recognize patient movement during cone beam CT examination with high specificity and to decide an early termination of the examination.

Validity of wax and acrylic as soft-tissue simulation materials used in in vitro radiographic studies.

OBJECTIVE: To determine the thickness of wax and acrylic that provides a radiographic density similar to that of the human cheek. METHODS: An intraoral film radiograph of the human cheek including a 40×30×3 mm reference aluminium block was recorded under standardized conditions in 61 subjects. Radiographic density was measured by a densitometer in ten randomly selected sites of the film to serve as the gold standard for density values of the cheek soft tissues. Thereafter, the density of series of radiographs of two tissue-simulating materials-wax and acrylic-in systematically increasing thicknesses (wax, 1.5-30 mm; acrylic, 2-40 mm) plus the reference block were measured and compared with the gold-standard values. RESULTS: The radiographic density of wax with a thickness of 13-17 mm or acrylic with a thickness of 14.5 mm corresponded to the average density of the human cheek. CONCLUSION: The soft tissues of the average human cheek can be simulated with 13-17 mm wax or 14.5 mm acrylic in in vitro radiographic studies.

Evaluation of the RB-RB/LB-LB mnemonic rule for recording optimally projected intraoral images of dental implants: an in vitro study.

OBJECTIVE: The aim of this study was to evaluate a simple mnemonic rule (the RB-RB/LB-LB rule) for recording intra-oral radiographs with optimal projection for the control of dental implants. METHODS: 30 third-year dental students received a short lesson in the RB-RB/LB-LB mnemonic rule. The rule is as follows: if right blur then raise beam (RB-RB), i.e. if implant threads are blurred at the right side of the implant, the X-ray beam direction must be raised towards the ceiling to obtain sharp threads on both implant sides; if left blur then lower beam (LB-LB), i.e. if implant threads are blurred at the left side of the implant, the X-ray beam direction must be lowered towards the floor to obtain sharp threads on both implant sides. Intra-oral radiographs of four screw-type implants placed with different inclination in a Frasaco upper or lower jaw dental model (Frasaco GmbH, Tettnang, Germany) were recorded. The students were unaware of the inclination of the implants and were instructed to re-expose each implant, implementing the mnemonic rule, until an image of the implant with acceptable quality (subjectively judged by the instructor) was obtained. Subsequently, each radiograph was blindly assessed with respect to sharpness of the implant threads and assigned to one of four quality categories: (1) perfect, (2) not perfect, but clinically acceptable, (3) not acceptable and (4) hopeless. RESULTS: For all implants, from one non-perfect exposure to the following, a higher score was obtained in 64% of the cases, 28% received the same score and 8% obtained a lower score. Only a small variation was observed among exposures of implants with different inclination. On average, two exposures per implant (range: one to eight exposures) were needed to obtain a clinically acceptable image. CONCLUSION: The RB-RB/LB-LB mnemonic rule for recording intra-oral radiographs of dental implants with a correct projection was easy to implement by inexperienced examiners.

Timing of implant placement relative to tooth extraction.

In recent years, immediate or early implant placement after tooth extraction has becoming more common. The present review focuses on the clinical outcome of immediate or early implant placement. Only limited knowledge exists about most of the factors with particular significance for this treatment mode. Randomized controlled clinical studies comparing the various treatment protocols are scarce. With the background in the existing literature some conclusions can be drawn with caution. Survival rates for implants placed immediately, early, delayed, or late seem to be similar in the short perspective and amounts to approximately 95%. Successful immediate implant placement may be possible in all regions of the jaws, although replacement of molars is more challenging. Chronic infection is not an absolute contraindication for immediate implant placement. It is controversial whether immediate placement of implants may preserve the alveolar bone. Small gaps between implant surface and socket wall have a potential for spontaneous healing. No consensus exists on the need for bone augmentation in these situations. With the limited information available it may be stated that a good prognosis can be obtained following immediate/early functional or non-functional loading of immediately placed implants. However, higher risk of failures seems to exist compared with a delayed, conventional approach. It is advocated that this treatment modality should be restricted to skilled well-trained teams. Data on the aesthetic outcomes following immediate/early implant placement are inconclusive, but this treatment can offer high patient satisfaction with the aesthetic and functional outcomes.

Impact of conventional tomography on prediction of the appropriate implant size.

AIM: The purpose of this study was to evaluate the efficacy of conventional cross-sectional tomography in predicting the appropriate implant size. METHODS: The implant length and width of 46 patients referred for single tooth implant treatment were determined presurgically by periapical + panoramic images (record 1) and after surgery by periapical + panoramic images + tomograms (record 2). These dimensions were compared with the dimensions of the implants actually installed (record 3), as well as the dimensions assessed to be the "appropriate" ones according to defined criteria for success (record 4). RESULTS: In 70% of the cases, the implant length or width, or both, was changed after the tomogram was available. The implant dimensions determined with tomography were maintained at surgery in 87% of the cases. In only 33% of the cases did the implant size predicted without tomography correspond with the size of the installed implants. The agreement between records 2 and 3 was significantly higher than between records 1 and 3 (P < .001). Similarly, the agreement between records 2 and 4 was significantly higher than between records 1 and 4 (P < .001). CONCLUSIONS: This study demonstrated that the use of tomograms increases the efficacy of periapical + panoramic images, with respect to the prediction of appropriate implant size, by a factor of 2.5. Therefore, conventional cross-sectional tomography is recommended for treatment planning before installation of single tooth implants.