The Prevalence of Depression in Dementia Syndrome.

BACKGROUND: It is estimated that up to 90% of patients with dementia are affected by behavioral and psychiatric symptoms during the course of the disease. The aim of this study was to investigate the prevalence of depression in dementia and mild cognitive impairment (MCI), the use of benzodiazepines and antidepressants among them and the impact of former education on their cognitive decline. SUBJECTS AND METHODS: In the study we have enrolled 100 patients with clinical diagnoses of either MCI or dementia, as was established by a single cognitive neurology subspecialist. All patients were assessed during their regular outpatient follow-ups in the University Clinical Center Zagreb, Croatia, in the period between November 2019 and March 2020. Using the patients' medical history the demographic data, disease characteristics, history of other diseases, use of medications, Mini-Mental State Examination (MMSE) and the data on radiological brain examinations were obtained. The statistical tests were used depending on the distribution of variables. RESULTS: In total, there were 34 patients diagnosed with dementia and 66 diagnosed with MCI. The diagnosis of depression before the onset of dementia or MCI was established in 11% and it has developed in further 20% after cognitive deterioration, which represents an increase of 81.81%. The total prevalence of depression in the study group is thus 31%.The proportion of patients taking benzodiazepines was 26% and antidepressants 17%.The MMSE scores were significantly lower in patients with Alzheimer's disease than in patients with vascular MCI or dementia. Generally, MMSE values correlated significantly with the duration of education. CONCLUSIONS: Depression is a frequent accompanying disease of dementia that aggravates already complex clinical picture and greatly diminishes the quality of life of the patient. It is important to monitor changes in a patient's cognitive decline and presence of psychiatric symptoms in order to give medical professionals a better chance to alleviate the complex issues that arise during the management of this specter of diseases.

Targeted Modification of Mitochondrial ROS Production Converts High Glucose-Induced Cytotoxicity to Cytoprotection: Effects on Anesthetic Preconditioning.

Contradictory reports on the effects of diabetes and hyperglycemia on myocardial infarction range from cytotoxicity to cytoprotection. The study was designed to investigate acute effects of high glucose-driven changes in mitochondrial metabolism and osmolarity on adaptive mechanisms and resistance to oxidative stress of isolated rat cardiomyocytes. We examined the effects of high glucose on several parameters of mitochondrial bioenergetics, including changes in oxygen consumption, mitochondrial membrane potential, and NAD(P)H fluorometry. Effects of high glucose on the endogenous cytoprotective mechanisms elicited by anesthetic preconditioning (APC) and the mediators of cell injury were also tested. These experiments included real-time measurements of reactive oxygen species (ROS) production and mitochondrial permeability transition pore (mPTP) opening in single cells by laser scanning fluorescence confocal microscopy, and cell survival assay. High glucose rapidly enhanced mitochondrial energy metabolism, observed by increase in NAD(P)H fluorescence intensity, oxygen consumption, and mitochondrial membrane potential. This substantially elevated production of ROS, accelerated opening of the mPTP, and decreased survival of cells exposed to oxidative stress. Abrogation of high glucose-induced mitochondrial hyperpolarization with 2,4 dinitrophenol (DNP) significantly, but not completely, attenuated ROS production to a level similar to hyperosmotic mannitol control. DNP treatment reversed high glucose-induced cytotoxicity to cytoprotection. Hyperosmotic mannitol treatment also induced cytoprotection. High glucose abrogated APC-induced mitochondrial depolarization, delay in mPTP opening and cytoprotection. In conclusion, high glucose-induced mitochondrial hyperpolarization abolishes APC and augments cell injury. Attenuation of high glucose-induced ROS production by eliminating mitochondrial hyperpolarization protects cardiomyocytes. J. Cell. Physiol. 232: 216-224, 2017. © 2016 Wiley Periodicals, Inc.

Epidemiology of Primary Headaches Among 1,876 Adolescents: A Cross-Sectional Survey.

BACKGROUND: The main goal of our research was to perform an epidemiological study of migraine and tension-type headache (TTH) among high school students in the Republic of Croatia. METHODS: The authors surveyed 1,876 students attending high schools in the Republic of Croatia using a self-administered 36-item questionnaire. RESULTS: Among 1,876 students who completed the questionnaire, prevalence of migraine was 12.8% (17% in women and 8.1% in men) and prevalence of TTH was 38.3% (40.6% in women and 35.7% in men). Prevalence of migraine with TTH was 2.9% (3.1% in women and 2.7% in men). The authors found a significantly greater prevalence of migraine in female than in male students (OR = 2.3), as in TTH (OR = 1.23). Compared with students with TTH, migraine sufferers were more inclined to take medications (OR = 3.29) and use health care (OR = 8.12) and were more likely to smoke (OR = 2.34). CONCLUSION: The prevalence of primary headaches in Croatia is similar to that in other countries of the world. TTH is the most common primary headache, occurring later in relation to migraine, and both types are more common in females. Teenagers who suffer from migraines are more likely to smoke in comparison to TTH. Although migraine patients visit the doctor and take medications more frequently than those with TTH, both headaches are being underdiagnosed and undertreated.