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8.
Agents Actions ; 41 Spec No: C68-9, 1994 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-7976808

RESUMEN

Central histaminergic modulation of H1 rather than H2-receptors has been shown to modify epileptic activity. Compounds acting on the HIC- and H3-receptors were tested against chemically-induced seizures in mice. Compounds antagonising the microsomal and nuclear intracellular receptors (HIC) only modified seizures at doses where toxicity was observed. Antagonists of the histamine H3-receptor (thioperamide and burimamide) only potentiated the severity of clonic convulsions induced by picrotoxin, while impromidine (i.c.v.), an antagonist with H2-agonist activity, inhibited leptazol-induced seizures. The H3-agonist, (R)alpha-methylhistamine, potentiated chemically-induced seizures, but at lower doses there was slight inhibition.


Asunto(s)
Receptores Histamínicos H3/fisiología , Convulsiones/inducido químicamente , Animales , Anticonvulsivantes/farmacología , Conducta Animal/efectos de los fármacos , Convulsivantes/farmacología , Agonistas de los Receptores Histamínicos , Antagonistas de los Receptores Histamínicos , Antagonistas de los Receptores Histamínicos H1/farmacología , Masculino , Ratones , Ratones Mutantes Neurológicos , Pentilenotetrazol , Picrotoxina
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