[Quality of life and 24 hour blood pressure profile in patients with hypertension].

122 patients aged 26 to 70 years (middle ages--54,1 +/- 2,8 years) who had history of arterial hypertension (AH) II stage have been observed. All patients conducted day's monitoring blood pressure (BP) and was determined their quality of life (QL) using the questionnaire of "SF-36 Health Status Survey". The results were conducted in accordance with instruction of the company of "Evidens are Clinico-pharmacological researches". Obtained results are represented in marks using 8 scales, more high mark specifies better QL. All observed patients with II stage hypertension have QL decreased. Decreased degree of night lowering of BP is associated with worsening of psychical status and more expressed limitation of physical activity in patients with hypertension than in those patients with hypertension who have normal day's type of BP.

[Effect of antihypertensive therapy on indices for lipid peroxidation and antioxidant system in patients with hypertensive heart]. / Vliianie antigipertenzivnoi terapii na pokazateli lipoperoksidatsii i antioksidantnoi sistemy bol'nykh s gipertenzivnym serdtsem.

In treating patients with hypertensive heart, effects of drugs on processes of lipoperoxidation should be taken into account since in heart remodelling there occurs an imbalance between peroxide oxidation on lipids and bodily antioxidant system of defence. Most investigators believe that calcium antagonists, beta- and alpha-adrenoblockers, inhibitors of the angiotensin-converting enzyme, nitrates, and some diuretics exert in some way or other a positive effect on the above imbalance. Further studies are warranted on a new class of hypotensive drugs--antagonists of angiotensin II receptors to free-radical oxidation of lipids.

[Effect of atenolol combined with chlortalidone on characteristics of 24-hour blood pressure monitoring]. / Vliianie atenolola v sochetanii s khloratalidonom na pokazateli sutochnogo monitoringa arterial'nogo davleniia.

Data are submitted concerning effects of atenol-H on indices for 24-hr monitoring of arterial pressure. As many as 34 patients were examined presenting with stage II hypertensive disease, in whom a 24-hr monitoring of AP was carried out in addition to a conventional measurement of AP as recommended by Korotkov before and after treatment with atenol-H, 1 tabletta per day (atenolol 100 mg, chlortolidon 25 mg). The course of treatment was on the average (26.8 +/- 1 to 4) days. As a result of treatment, values for 24-hr, day, and night AP have gotten decreased. No serious complications have been revealed to warrant withdrawal of the drug.

[Enterosorbents in the treatment of atherosclerosis]. / Enterosorbenty v lechenii ateroskleroza.

The article lists, characterizes, and discusses the mechanism of the action of endosorbents possessing hypocholesteremic and hypolipidemic effects. Among them are natural endosorbents--food fibers (cellulose, hemicellulose, pectins, gum, mucus, lignin and chitin compounds, etc.); artificial specific affinin and nonspecific carbonic enterosorbents (carbonitrate family, granulated, fibrous), as well as silica (aerosil, polysorb). The effectiveness and pathogenetic expediency of correcting disorders of lipid metabolism in atherosclerosis with enterosorbents is substantiated.

[Blood lipids, lipid peroxidation and the effect on them of antianginal preparations in ischemic heart disease patients]. / Lipidy krovi, lipoperoksidatsiia i vliianie na nikh antianginal'nykh preparatov u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The origin and development of ischemic heart disease (IHD) is attended with activation of lipid free-radical oxidation facilitating further advancement of the disease and with decrease of the organism's antioxidant protection. The antianginal drugs which are used in IHD treatment differ in their effect on the blood lipid composition and their peroxidation. beta-Adrenoblocking agents may cause proatherogenic disorders of the blood lipid graph, this increases the risk of IHD advancement. Long-acting nitro preparations are lipid-neutral. Calcium antagonists, mainly those of the nifedipin group, suppress LPO superactivity, possess a high antioxidant effect, and, probably, retard the advancement of coronary atherosclerosis and IHD.

[The possible means for the pharmacological correction of lipid metabolic disorders in atherosclerosis]. / Vozmozhnye puti farmakologicheskoi korrektsii narushenii lipidnogo obmena pri ateroskleroze.

The main trends of contemporary pharmacology of hypolipidemic and hypocholesterolemic agents were analysed. A list of drugs capable of correcting lipid metabolism disorders is given: cholesterol absorption inhibitors, stimulators of bile acid synthesis, inhibitors of cholesterol synthesis, analogs of fibroic acid and other inhibitors and correctors of hypertriglyceridemias, stimulators of reverse cholesterol transport and synthesis of high-density lipoproteins, etc. The latest theoretical and experimental elaborations of gene therapy of dyslipoproteinemias in atherosclerosis are discussed.

[The oxidant and antioxidant systems in patients with stable stenocardia and with a history of small- and large-focus myocardial infarcts]. / Sostoianie oksidantnoi i antioksidantnoi sistem u bol'nykh stabil'noi stenokardiei i perenesshikh melko- i krupnoochagovyi infarkt miokarda.

A study was made as well as a comparison of values of the cholesterol (Chs) lipid fractions concentrations, and of those of the lipid peroxidation processes activity (LPP) and the gluthathione antioxidant system (AOS) status in male subjects aged from 45 to 59 years, healthy individuals and patients with stable angina pectoris and myocardial infarction (micro- and macrofocal) during cicatrizing stage (health resort rehabilitation stage). In patients with various forms of IHD total cholesterol is raised as are atherogenic lipoproteins, and atherogenicity index, intensification being noted of LPO along with a considerable decrease in functional potencies of AOS. Similar pattern of changes of LPO and AOS in patients with stable angina pectoris and myocardial infarction (MI) during cicatrization stage certainly warrants correction of these systems not only in acute phase of MI but at the stage of rehabilitation as well.

[Experience from a 10-year prospective prophylactic examination of the workers of a computer manufacturing factory]. / Opyt 10-letnego prospektivnogo profilakticheskogo obsledovaniia rabotnikov predpriiatiia po proizvodstvu sredstv vychislitel'noi tekhniki.

A prospective epidemiological study was carried out for 10 years at a factory manufacturing computers using an automated information system functioning on the basis of microcomputers CM-1800. The genuine prevalence of cardiovascular diseases and risk factors of their onset was revealed. Methods of early diagnosis of the diseases were suggested, variants of the controlled therapy were elaborated. The study resulted in a decrease of the morbidity with a temporary loss of work fitness because of coronary heart disease, namely from 52.8 days in 1980 to 42.7 days per 100 workers in 1989.

[Use of foridon in the treatment of arterial hypertension and hypertension of the lesser circulation]. / Primenenie foridona dlia lecheniia arterial'nykh gipertonii i gipertonii malogo kruga krovoobrashcheniia.

Hypotensive effect of foridon was evaluated in 68 patients with first- and second-stage essential hypertension, 17 patients with renal hypertension and 18 patients with pulmonary hypertension. Changes in clinical condition, central hemodynamics, pulmonary arterial systolic pressure, inhalation and exhalation intensity were assessed. Foridon effect was shown to be largely due to reduced peripheral resistance. Foridon (30-60 mg) was effective in first-stage essential hypertension. In second-stage hypertension, foridon alone did not always produce an effect. In such cases, foridon-clofelin combination where clofelin hypotensive effect is enhanced can produce a marked hypotensive effect. Foridon is not indicated for the treatment of renal hypertension. Its use as part of combined treatment for chronic nonspecific pulmonary diseases where it is to reduce pulmonary hypertension, is justified.

[Efficacy of preventing ischemic heart disease and arterial hypertension at a factory manufacturing computer equipment]. / Effektivnost' profilaktiki ishemicheskoi bolezni serdtsa i arterial'noi gipertonii na predpriiatii po proizvodstvu sredtsv vychislitel'noi tekhniki.

The results of a prospective 5-year survey of workers and employees at a computer manufacturing enterprise were summed up. The true prevalence of CHD (11.7% of examinees), arterial hypertension (16.5%), and risk factors of these diseases were established. A scheme of controlled therapy of CHD and arterial hypertension was developed and tested. The annual economic effect of the survey was 4038 rub. per 1000 examinees.