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1.
Int. arch. otorhinolaryngol. (Impr.) ; 27(3): 400-406, Jul.-Sept. 2023. tab
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1514241

RESUMEN

Abstract Introduction Tinnitus is a prevalent condition among many different populations. Since tinnitus is subjective, self-report questionnaires are one way of assessing how much the condition interferes with the quality of life of an individual. Objective The aim of the present study was to translate and cross-culturally adapt the Skarzynski Tinnitus Scale (STS) into Brazilian Portuguese and validate its psychometric properties. Methods The STS was translated and cross-culturally adapted using five main steps. Fifty-eight individuals who had continuous tinnitus were invited to complete the questionnaire. Pure tone audiometry (air and bone conduction) were also done. Results No major changes were necessary in translating the scale. The overall score was 1.3 (range 0-4). Internal consistency was tested by Cronbach α, which ranged from 0.54 to 0.85. Differences between genders and between subscales and the total score were not significant. A statistically significant difference was only found in the coping subscale, in which normal hearing subjects had higher scores than those with hearing loss. Conclusion The translation and adaptation of the STS established linguistic and cultural equivalence with the original. In addition, it exhibited good internal consistency. Our results suggest that the STS is suitable for use in a clinical setting.

2.
Int Arch Otorhinolaryngol ; 27(3): e400-e406, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37564479

RESUMEN

Introduction Tinnitus is a prevalent condition among many different populations. Since tinnitus is subjective, self-report questionnaires are one way of assessing how much the condition interferes with the quality of life of an individual. Objective The aim of the present study was to translate and cross-culturally adapt the Skarzynski Tinnitus Scale (STS) into Brazilian Portuguese and validate its psychometric properties. Methods The STS was translated and cross-culturally adapted using five main steps. Fifty-eight individuals who had continuous tinnitus were invited to complete the questionnaire. Pure tone audiometry (air and bone conduction) were also done. Results No major changes were necessary in translating the scale. The overall score was 1.3 (range 0-4). Internal consistency was tested by Cronbach α, which ranged from 0.54 to 0.85. Differences between genders and between subscales and the total score were not significant. A statistically significant difference was only found in the coping subscale, in which normal hearing subjects had higher scores than those with hearing loss. Conclusion The translation and adaptation of the STS established linguistic and cultural equivalence with the original. In addition, it exhibited good internal consistency. Our results suggest that the STS is suitable for use in a clinical setting.

3.
PLoS Negl Trop Dis ; 15(9): e0008792, 2021 09.
Artículo en Inglés | MEDLINE | ID: mdl-34506499

RESUMEN

The present study reports the occurrence of rotavirus A (RVA), rotavirus D (RVD), rotavirus F (RVF), rotavirus G (RVG), and picobirnavirus (PBV) in fecal specimens of wild (n = 22), and exotic birds (n = 1) from different cities of Pará state. These animals were hospitalized at Veterinary Hospital of the Federal University of Pará, Brazil, in a period from January 2018 to June 2019. The animals exhibited different clinical signs, such as diarrhea, malnutrition, dehydration, and fractures. The results showed 39.1% (9/23) of positivity for RVA by RT-qPCR. Among these, one sample (1/9) for the NSP3 gene of T2 genotype was characterized. About 88.9% (8/9) for the VP7 gene belonging to G1, G3 equine like and G6 genotypes, and 55.5% (5/9) for the VP4 gene of P[2] genotype were obtained. In the current study, approximately 4.5% of the samples (1/23) revealed coinfection for the RVA, RVD and RVF groups. Furthermore, picobirnavirus (PBV) was detected in one of the 23 samples tested, and was classified in the Genogroup I. The findings represent the first report of RVA, RVD, RVF, RVG, and PBV genotypes in wild birds in Brazil, and due to wide distribution it can implies potential impacts of RVs, and PBVs on avian health, and other animals contributing to construction of new knowledge, and care perspectives.


Asunto(s)
Enfermedades de las Aves/virología , Picobirnavirus/aislamiento & purificación , Infecciones por Virus ARN/veterinaria , Infecciones por Rotavirus/veterinaria , Rotavirus/aislamiento & purificación , Animales , Animales Salvajes , Enfermedades de las Aves/epidemiología , Aves , Brasil/epidemiología , Heces/virología , Genotipo , Filogenia , Picobirnavirus/genética , Infecciones por Virus ARN/epidemiología , Infecciones por Virus ARN/virología , Rotavirus/genética , Infecciones por Rotavirus/epidemiología , Infecciones por Rotavirus/virología
4.
Molecules ; 26(15)2021 Jul 24.
Artículo en Inglés | MEDLINE | ID: mdl-34361622

RESUMEN

Jaboticaba is a Brazilian native berry described as a rich source of phenolic compounds (PC) with health promoting effects. PC from jaboticaba peel powder (JPP) have low intestinal bio-accessibility and are catabolized by gut microbiota. However, the biological implication of PC-derived metabolites produced during JPP digestion remains unclear. This study aimed to evaluate the antiproliferative effects of colonic fermented JPP (FJPP) in a 3D model of colorectal cancer (CRC) composed by HT29 spheroids. JPP samples fermented with human feces during 0, 2, 8, 24 or 48 h were incubated (10,000 µg mL-1) with spheroids, and cell viability was assessed after 72 h. Chemometric analyses (cluster and principal component analyses) were used to identify the main compounds responsible for the bioactive effect. The antiproliferative effect of FJPP in the CRC 3D model was increased between 8 h and 24 h of incubation, and this effect was associated with HHDP-digalloylglucose isomer and dihydroxyphenyl-γ-valerolactone. At 48 h of fermentation, the antiproliferative effect of FJPP was negligible, indicating that the presence of urolithins did not improve the bioactivity of JPP. These findings provide relevant knowledge on the role of colonic microbiota fermentation to generate active phenolic metabolites from JPP with positive impact on CRC.


Asunto(s)
Antineoplásicos/farmacología , Antioxidantes/farmacología , Proliferación Celular/efectos de los fármacos , Neoplasias Colorrectales/tratamiento farmacológico , Myrtaceae/química , Fenoles/farmacología , Células CACO-2 , Supervivencia Celular/efectos de los fármacos , Células HT29 , Humanos , Extractos Vegetales/farmacología
5.
Future Microbiol ; 16: 847-862, 2021 08.
Artículo en Inglés | MEDLINE | ID: mdl-34318682

RESUMEN

Aim: To perform a molecular analysis of rotavirus A (RVA) G3P[6] strains detected in 2012 and 2017 in the Amazon region of Brazil. Materials & methods: Eighteen RVA G3P[6] strains were collected from children aged under 10 years hospitalized with acute gastroenteritis, and partial sequencing of each segment genome was performed using Sanger sequencing. Results: Phylogenetic analysis showed that all G3P[6] strains had a DS-1-like genotype constellation. Two strains had the highest nucleotide identities with equine-like G3P[6]/G3P[8] genotypes. Several amino acid alterations in VP4 and VP7 neutralizing epitopes of equine-like RVA G3P[6] strains were observed in comparison with vaccine strains. Conclusion: These findings suggest that equine-like RVA G3P[6] strains have been circulating in the Amazon region of Brazil as a result of direct importation, and support natural RVA evolutionary mechanisms.


Asunto(s)
Genoma Viral , Virus Reordenados , Rotavirus , Animales , Brasil , Niño , Caballos , Humanos , Filogenia , Rotavirus/genética , Rotavirus/aislamiento & purificación
6.
Food Res Int ; 131: 109026, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-32247467

RESUMEN

This work aimed to contribute to the nutritional and functional characterization of roasted baru nuts, a seed widely consumed and produced in Brazil. Baru nut was characterized in terms of its nutritional value and volatile composition (SPME-GC-MS analysis). The ultrasound assisted extraction was used to extract free and bound phenolic compounds that were identified by LC-DAD-ESI-MS/MS method. Bioactivity assays were carried out to evaluate the antioxidant activity (ORAC and HOSC assay) and anticancer effect (inhibition of HT29 cell growth and targeting of cancer stemness) of baru nut extracts and phenolic compounds. Results showed that baru is a good source of protein and monounsaturated fatty acids, specifically oleic acid (47.20 g/100 g). The predominant volatile compounds are hexanal (71.18%) and 2,5-dimethyl-pyrazine (9.43%). The main phenolic compounds identified were gallic acid and its derivatives, such as gallic acid esters and gallotannins. Among all, gallic acid and methyl gallate seemed to be the main compounds responsible for the high antioxidant activity. The antiproliferative effect evaluated of baru extracts in HT29 cell line showed ability to impair cell growth in both monolayer and spheroid cultures and to reduce ALDH+ population. These results supply new information about the functional compounds presents in baru nut, which are important sources of natural antioxidants and antiproliferative compounds.


Asunto(s)
Antioxidantes/análisis , Dipteryx/química , Valor Nutritivo , Nueces/química , Fenoles/análisis , Brasil , Proliferación Celular/efectos de los fármacos , Cromatografía Liquida , Ácidos Grasos/análisis , Ácido Gálico/análogos & derivados , Ácido Gálico/análisis , Cromatografía de Gases y Espectrometría de Masas , Células HT29 , Humanos , Taninos Hidrolizables/análisis , Extractos Vegetales/análisis , Extractos Vegetales/farmacología , Semillas/química , Espectrometría de Masa por Ionización de Electrospray , Espectrometría de Masas en Tándem , Compuestos Orgánicos Volátiles/análisis
7.
Cien Saude Colet ; 23(9): 2859-2868, 2018 Sep.
Artículo en Portugués, Inglés | MEDLINE | ID: mdl-30281724

RESUMEN

The realization of the right to health of adolescents and young people deprived of their liberty in Brazil is a complex task that places us before health inequities and interventions on their social determinants of health. Therefore, this study sought to contribute to a discussion about the right to health of this population, based on the analysis of the implementation of the Comprehensive Healthcare Policy for Adolescent Offenders (PNAISARI). This is an analytical approach, using documentary analysis of legal frameworks and policy monitoring and evaluation data. In short, the results suggest that the policy strengthens the realization of the right to health of this population. However, its implementation must be promoted and qualified so that access to health care is, in fact, a reality in all states and municipalities.


A efetivação do direito à saúde de adolescentes e jovens privados de liberdade no Brasil é tarefa complexa que nos coloca frente às iniquidades em saúde e às intervenções sobre seus determinantes sociais. Sendo assim, o presente estudo buscou contribuir com a discussão sobre o direito à saúde dessa população, a partir da análise da implementação da Política de Atenção Integral à Saúde de Adolescentes em Conflito com a Lei (PNAISARI). Trata-se de um estudo de abordagem analítica, utilizando análise documental dos marcos normativos e de dados de monitoramento e avaliação da política. Em suma, os resultados sugerem que a política fortalece a efetivação do direito a saúde dessa população. Entretanto, sua implementação necessita ser fomentada e qualificada para que o acesso aos cuidados em saúde seja de fato uma realidade em todos os estados e municípios.


Asunto(s)
Atención Integral de Salud/organización & administración , Política de Salud , Accesibilidad a los Servicios de Salud/legislación & jurisprudencia , Delincuencia Juvenil/legislación & jurisprudencia , Adolescente , Salud del Adolescente , Brasil , Derechos Humanos/legislación & jurisprudencia , Humanos , Determinantes Sociales de la Salud
8.
Ciênc. Saúde Colet. (Impr.) ; Ciênc. Saúde Colet. (Impr.);23(9): 2859-2868, set. 2018. tab
Artículo en Portugués | LILACS | ID: biblio-952777

RESUMEN

Resumo A efetivação do direito à saúde de adolescentes e jovens privados de liberdade no Brasil é tarefa complexa que nos coloca frente às iniquidades em saúde e às intervenções sobre seus determinantes sociais. Sendo assim, o presente estudo buscou contribuir com a discussão sobre o direito à saúde dessa população, a partir da análise da implementação da Política de Atenção Integral à Saúde de Adolescentes em Conflito com a Lei (PNAISARI). Trata-se de um estudo de abordagem analítica, utilizando análise documental dos marcos normativos e de dados de monitoramento e avaliação da política. Em suma, os resultados sugerem que a política fortalece a efetivação do direito a saúde dessa população. Entretanto, sua implementação necessita ser fomentada e qualificada para que o acesso aos cuidados em saúde seja de fato uma realidade em todos os estados e municípios.


Abstract The realization of the right to health of adolescents and young people deprived of their liberty in Brazil is a complex task that places us before health inequities and interventions on their social determinants of health. Therefore, this study sought to contribute to a discussion about the right to health of this population, based on the analysis of the implementation of the Comprehensive Healthcare Policy for Adolescent Offenders (PNAISARI). This is an analytical approach, using documentary analysis of legal frameworks and policy monitoring and evaluation data. In short, the results suggest that the policy strengthens the realization of the right to health of this population. However, its implementation must be promoted and qualified so that access to health care is, in fact, a reality in all states and municipalities.


Asunto(s)
Humanos , Adolescente , Atención Integral de Salud/organización & administración , Política de Salud , Accesibilidad a los Servicios de Salud/legislación & jurisprudencia , Delincuencia Juvenil/legislación & jurisprudencia , Brasil , Salud del Adolescente , Determinantes Sociales de la Salud , Derechos Humanos/legislación & jurisprudencia
9.
J Med Virol ; 89(6): 974-981, 2017 06.
Artículo en Inglés | MEDLINE | ID: mdl-27862014

RESUMEN

The species A rotaviruses (RVA) are important gastroenteric pathogens that infect humans and animals. RVA genotype G3P[9] has been described in human-animal reassortment events, and the complexity of its hosts motivates the genetic investigation of this strain. Therefore, the aim of this study is to analyse a G3P[9] sample that was detected in a child with acute gastroenteritis. The 1A3739 sample featured the constellation G3P[9]-I18-R3-C3-Mx-A19-N3-T3-E3-H6. The sequence for VP3 gene was not obtained. The phylogeny showed a closer relationship among genes VP7, VP1, NSP3, NSP4, and NSP5 with genes of animal origin, such as chiropter, alpaca, equine, and simian. In addition, the genes VP6 and NSP1 belong to the new genotypes I18 and A19, respectively. The emergence of strains such as these can interfere with the effectiveness of the RVA vaccine, and continuous monitoring is therefore important. Additional studies are needed to determine the evolutionary source and to identify a possible reservoir of RVA in nature.


Asunto(s)
Gastroenteritis/virología , Genotipo , Virus Reordenados/genética , Infecciones por Rotavirus/virología , Rotavirus/genética , Preescolar , Evolución Molecular , Femenino , Humanos , Filogenia , Recombinación Genética , Rotavirus/aislamiento & purificación , Análisis de Secuencia de ADN
12.
Acta Otolaryngol ; 132(7): 732-8, 2012 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-22404258

RESUMEN

CONCLUSION: The patients with unilateral chronic vestibular hypofunction detected by caloric test demonstrated at least some sort of altered vestibular evoked myogenic potential (VEMP) in 63.63% of the cases. The VEMP altered side was the same as the unilateral vestibular hypofunction side in 54.54% of the cases and was the opposite side in 24.24%. The VEMP test improved functional vestibular assessment in patients with unilateral caloric hypofunction. OBJECTIVES: To analyze VEMP in patients with chronic dizziness and unilateral vestibular hypofunction and verify findings according to the side and structures involved. METHODS: This was an observational study. In all, 66 subjects were evaluated by VEMP (tone bursts/1000 Hz/100 dBnHL/bandpass filtered 10-1500 Hz/4.3 Hz rate), 33 with unilateral vestibular hypofunction, detected by caloric test and clinical data, and 33 control subjects, matched by gender and age. Amplitude of the p13-n23, asymmetry index of the amplitude, p13 and n23 latencies, p13 and n23 interaural difference and threshold were analyzed. Simple descriptive analysis was carried out using the t test, Shapiro-Wilks test, and Mann-Whitney test, p < 0.05. RESULTS: VEMP was altered in patients with unilateral vestibular hypofunction in 63.63% of cases. Thirteen of them were ipsilateral to the vestibular hypofunction and three were contralateral to the vestibular hypofunction. In five cases, VEMP were bilaterally altered.


Asunto(s)
Mareo/fisiopatología , Enfermedades Vestibulares/fisiopatología , Potenciales Vestibulares Miogénicos Evocados/fisiología , Estimulación Acústica , Adolescente , Adulto , Pruebas Calóricas , Estudios de Casos y Controles , Mareo/diagnóstico , Mareo/etiología , Electromiografía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tiempo de Reacción/fisiología , Reproducibilidad de los Resultados , Enfermedades Vestibulares/complicaciones , Enfermedades Vestibulares/diagnóstico , Adulto Joven
13.
Microbiol Res ; 167(6): 317-25, 2012 Jun 20.
Artículo en Inglés | MEDLINE | ID: mdl-22192836

RESUMEN

Through the use of molecular and biochemical experiments and bioinformatic tools, this work demonstrates that the PA4921 gene of the Pseudomonas aeruginosa PAO1 genome is a gene responsible for cholinesterase (ChoE) activity. Similar to the acetylcholinesterase (AchE) of Zea mays, this ChoE belongs to the SGNH hydrolase family. In mature ChoE, i.e., without a signal peptide, (18)Ser, (78)Gly, (127)N, and (268)H are conserved aminoacyl residues. Acetylthiocholine (ATC) and propionylthiocholine (PTC) are substrates of this enzyme, but butyrylcholine is an inhibitor. The enzyme also catalyzes the hydrolysis of the artificial esters p-nitrophenyl propionate (pNPP) and p-nitrophenyl butyrate (pNPB) but with lower catalytic efficiency with respect to ATC or PTC. The second difference is that pNPP and pNPB did not produce inhibition at high substrate concentrations, as occurred with ATC and PTC. These differences plus preliminary biochemical and kinetic studies with alkylammonium compounds led us to propose that this enzyme is an acetylcholinesterase (AchE) or propionylcholinesterase. Studies performed with the purified recombinant enzyme indicated that the substrate saturation curves and the catalytic mechanism are similar to those properties described for mammalian AchEs. Therefore, the results of this work suggest that the P. aeruginosa ChoE is an AchE that may also be found in Pseudomonas fluorescens.


Asunto(s)
Acetilcolinesterasa/genética , Acetilcolinesterasa/metabolismo , Pseudomonas aeruginosa/enzimología , Pseudomonas aeruginosa/genética , Acetilcolinesterasa/química , Acetilcolinesterasa/clasificación , Acetiltiocolina/metabolismo , Colina/análogos & derivados , Colina/metabolismo , Secuencia Conservada , Inhibidores Enzimáticos/metabolismo , Hidrolasas/química , Hidrolasas/clasificación , Hidrolasas/genética , Hidrolasas/metabolismo , Cinética , Filogenia , Homología de Secuencia de Aminoácido , Especificidad por Sustrato , Tiocolina/análogos & derivados , Tiocolina/metabolismo , Zea mays/enzimología , Zea mays/genética
14.
GED gastroenterol. endosc. dig ; GED gastroenterol. endosc. dig;30(4): 163-167, out.-dez. 2011. ilus
Artículo en Portugués | LILACS | ID: lil-678922

RESUMEN

Desde a descoberta do vírus da hepatite C (VHC), em 1989, a hepatite C passou a ganhar especial relevância entre as causas de doença hepática crônica no mundo. Estima-se que aproximadamente 3% da população mundial estejam infectados pelo vírus da hepatite C, o que representa cerca de 170 milhões de indivíduos com infecção crônica e sob risco de desenvolver as complicações da doença. Trata-se, portanto, de um dos maiores problemas de saúde pública enfrentados mundialmente. A infecção pelo VHC está associada a um amplo espectro de manifestações clínicas: hepáticas, sistêmicas e cutâneas. As manifestações cutâneas são muitas vezes os primeiros sinais da infecção pelo VHC. Os médicos devem estar atentos a estas manifestações, pois o diagnóstico precoce é importante para o sucesso terapêutico. Deve-se suspeitar de contaminação pelo VHC em pacientes que apresentem: crioglobulinemia mista, liquen plano, livedo reticular, poliarterite nodosa, porfiria cutânea tarda, prurido e urticária crônica.


Since the discovery of hepatitis C virus (HCV) in 1989, hepatitis C has been gaining special importance among the causes of chronic liver disease worldwide. It is estimated that approximately 3% of world population are infected with hepatitis C, which represents about 170 million people chronically infected and at risk of developing complications of the disease. It is therefore a major public health problems facing the world². HCV infection is associated with a broad spectrum of clinical manifestations: liver, skin and systemic. Cutaneous manifestations are often the first signs of HCV infection. Physicians should be aware of these manifestations, because early diagnosis is important for successful treatment. Should be suspected of contamination by HCV in patients who have: mixed cryoglobulinemia, lichen planus, livedo reticularis, polyarteritis nodosa, porphyria cutanea tarda, pruritus and chronic urticaria.


Asunto(s)
Humanos , Enfermedades de la Piel , Hepatitis C , Poliarteritis Nudosa , Prurito , Porfiria Cutánea Tardía , Crioglobulinemia , Livedo Reticularis , Liquen Plano
15.
Arq Neuropsiquiatr ; 69(3): 485-90, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21755127

RESUMEN

OBJECTIVE: To evaluate balance control with Balance Rehabilitation Unit (BRU™) posturography in patients with multiple sclerosis (MS). METHOD: A cross controlled study was performed including 39 relapsing-remitting multiple sclerosis patients with scores less than or equal to 4 in the Expanded Disability Status Scale (EDSS), and a homogeneous control group consisting of 65 healthy individuals, matched by the age and gender. The experimental group was distributed according to the EDSS scale scores in 0-2.5 and 3-4. To assess the vestibular system function, the patients underwent a neurotological evaluation, including posturography of the Balance Rehabilitation Unit (BRU™). RESULTS: Statistically significant differences were observed when comparing the values of the sway velocity and the ellipse area of the MS 0-2.5 group with the control and the MS 3-4 group with the control. A statistically significant difference was verified between the MS 0-2.5 and the MS 3-4 groups in the condition 3 ellipse area values. CONCLUSION: The evaluation of the balance control with posturography of Balance Rehabilitation Unit (BRU™) enables the identification of abnormalities of the sway velocity and confidential ellipse in patients with relapsing-remitting multiple sclerosis.


Asunto(s)
Mareo/fisiopatología , Esclerosis Múltiple Recurrente-Remitente/fisiopatología , Equilibrio Postural/fisiología , Pruebas de Función Vestibular/métodos , Adulto , Estudios de Casos y Controles , Estudios Transversales , Femenino , Humanos , Masculino
16.
Arq. neuropsiquiatr ; Arq. neuropsiquiatr;69(3): 485-490, June 2011. tab
Artículo en Inglés | LILACS | ID: lil-592508

RESUMEN

OBJECTIVE: To evaluate balance control with Balance Rehabilitation Unit (BRU TM) posturography in patients with multiple sclerosis (MS). METHOD: A cross controlled study was performed including 39 relapsing-remitting multiple sclerosis patients with scores less than or equal to 4 in the Expanded Disability Status Scale (EDSS), and a homogeneous control group consisting of 65 healthy individuals, matched by the age and gender. The experimental group was distributed according to the EDSS scale scores in 0-2.5 and 3-4. To assess the vestibular system function, the patients underwent a neurotological evaluation, including posturography of the Balance Rehabilitation Unit (BRU TM). RESULTS: Statistically significant differences were observed when comparing the values of the sway velocity and the ellipse area of the MS 0-2.5 group with the control and the MS 3-4 group with the control. A statistically significant difference was verified between the MS 0-2.5 and the MS 3-4 groups in the condition 3 ellipse area values. CONCLUSION: The evaluation of the balance control with posturography of Balance Rehabilitation Unit (BRU TM) enables the identification of abnormalities of the sway velocity and confidential ellipse in patients with relapsing-remitting multiple sclerosis.


OBJETIVO: Avaliar o equilíbrio corporal à posturografia do Balance Rehabilitation Unit (BRU TM) em pacientes com esclerose múltipla (EM). MÉTODO: Estudo transversal controlado em 39 pacientes com esclerose múltipla do tipo recorrente-remitente, com pontuação menor ou igual a 4 na escala de incapacidade funcional expandida, e por um grupo controle homogêneo, constituído por 65 indivíduos hígidos, homogêneo em relação à idade e gênero. O grupo experimental foi distribuído, de acordo com a pontuação da EDSS, em 0-2,5 e 3-4. Para avaliar a função do sistema vestibular, os pacientes foram submetidos a uma avaliação otoneurológica, incluindo a posturografia do Balance Rehabilitation Unit (BRU TM). RESULTADOS: Foram observadas diferenças significantes na comparação dos valores da velocidade de oscilação e da área de elipse do grupo EM 0-2,5 com o controle e do grupo EM 3-4 com o controle; diferença significante foi verificada entre os grupos EM 0-2,5 e EM 3-4 nos valores da área de elipse na condição três. CONCLUSÃO: A avaliação do equilíbrio corporal por meio da posturografia do Balance Rehabilitation Unit (BRU TM) possibilita a identificação de anormalidades da velocidade de oscilação e da área de elipse em pacientes com esclerose múltipla.


Asunto(s)
Adulto , Femenino , Humanos , Masculino , Mareo/fisiopatología , Esclerosis Múltiple Recurrente-Remitente/fisiopatología , Equilibrio Postural/fisiología , Pruebas de Función Vestibular/métodos , Estudios de Casos y Controles , Estudios Transversales
17.
Braz J Otorhinolaryngol ; 75(5): 701-5, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19893939

RESUMEN

UNLABELLED: Metabolic disorders can cause dizziness. AIM: to study the prevalence of glucose and glucose-insulin alterations in patients with peripheral vestibular disorders by studying the four-hour glucose-insulin curve; to check at what time there was the highest prevalence of altered cases and whether the glucose and insulin curves together are better than the isolate glucose curve and fasting glucose curve. MATERIALS AND METHODS: retrospective study, analyzing 81 four-hour glucose-insulin curves in patients with peripheral vestibular dizziness. RESULTS: Four-hour glucose-insulin curve alterations happened in 87.7% of the patients. Hypoglycemia was seen in 61.7% of the cases, hyperinsulinemia in 55.5%, hyperglycemia in 27.2%, glucose intolerance in 12.3% and hypoinsulinemia in 1.2%. Normal tests were seen in 12.3 % of the cases and altered fasting glucose in 23.5%. CONCLUSIONS: The four-hour glucose-insulin curve analysis showed that 87.7% of the patients with dizziness and suspicion of peripheral vestibular disorder had glucose or insulin metabolism disorders. The highest number of alterations was seen up to the third and fourth hour of the glucose-insulin curve. The glucose and insulin curves together overcame the glucose curve alone and fasting glucose curve in regards of the prevalence of altered cases.


Asunto(s)
Glucemia/análisis , Mareo/sangre , Insulina/sangre , Enfermedades Vestibulares/sangre , Humanos , Prevalencia , Estudios Retrospectivos
18.
Braz. j. otorhinolaryngol. (Impr.) ; Braz. j. otorhinolaryngol. (Impr.);75(5): 701-705, Sept.-Oct. 2009. tab
Artículo en Inglés, Portugués | LILACS | ID: lil-530094

RESUMEN

Metabolic disorders can cause dizziness. AIM: to study the prevalence of glucose and glucose-insulin alterations in patients with peripheral vestibular disorders by studying the four-hour glucose-insulin curve; to check at what time there was the highest prevalence of altered cases and whether the glucose and insulin curves together are better than the isolate glucose curve and fasting glucose curve. MATERIALS AND METHODS: retrospective study, analyzing 81 four-hour glucose-insulin curves in patients with peripheral vestibular dizziness. RESULTS: Four-hour glucose-insulin curve alterations happened in 87.7 percent of the patients. Hypoglycemia was seen in 61.7 percent of the cases, hyperinsulinemia in 55.5 percent, hyperglycemia in 27.2 percent, glucose intolerance in 12.3 percent and hypoinsulinemia in 1.2 percent. Normal tests were seen in 12.3 percent of the cases and altered fasting glucose in 23.5 percent. CONCLUSIONS: The four-hour glucose-insulin curve analysis showed that 87.7 percent of the patients with dizziness and suspicion of peripheral vestibular disorder had glucose or insulin metabolism disorders. The highest number of alterations was seen up to the third and fourth hour of the glucose-insulin curve. The glucose and insulin curves together overcame the glucose curve alone and fasting glucose curve in regards of the prevalence of altered cases.


Alterações metabólicas podem causar tontura. OBJETIVOS: Identificar a prevalência das alterações glicêmicas e glicoinsulinêmicas em pacientes com vestibulopatia periférica por meio da curva glicoinsulinêmica de 4 horas; verificar em que momento do exame foi encontrada a maior prevalência de casos alterados e se as curvas glicêmica e insulinêmica em conjunto superam a curva glicêmica isolada e glicemia de jejum. MATERIAL E MÉTODO: Estudo retrospectivo, com análise de 81 curvas glicoinsulinêmicas de quatro horas em pacientes com queixa de tontura de origem vestibular periférica. RESULTADOS: Alterações na curva glicoinsulinêmica de 4 horas ocorreram em 87,7 por cento dos pacientes. Hipoglicemia ocorreu em 61,7 por cento dos casos, hiperinsulinemia em 55,5 por cento, hiperglicemia em 27,2 por cento, intolerância à glicose em 12,3 por cento e hipoinsulinemia em 1,2 por cento. Exame normal em 12,3 por cento dos casos e glicemia de jejum alterada em 23,5 por cento. CONCLUSÕES: A análise da curva glicoinsulinêmica de 4 horas evidenciou que 87,7 por cento dos pacientes com tontura e hipótese de disfunção vestibular periférica apresentaram alterações do metabolismo da glicose ou insulina. O maior número de alterações foi encontrado até a terceira e quarta horas da curva glicoinsulinêmica. As curvas glicêmicas e insulinêmicas em conjunto superaram a curva glicêmica isolada e glicemia de jejum quanto à prevalência de casos alterados.


Asunto(s)
Humanos , Glucemia/análisis , Mareo/sangre , Insulina/sangre , Enfermedades Vestibulares/sangre , Prevalencia , Estudios Retrospectivos
19.
Odontol. clín.-cient ; 6(3): 213-218, jul.-set. 2007. tab, graf
Artículo en Portugués | LILACS, BBO - Odontología | ID: lil-509926

RESUMEN

o presente trabalho objetiva abordar, através de revisão da literatura, os desafios e as perspectivas originadas pela inserção da Odontologiano Programa Saúde da Família (PSF). Para tanto, inicialmente procurou-se analisar a origem do Programa, em que contexto, por que e para quem foi criado, seguindo-se de um breve relato sobre o mercado de trabalho odontológico e o paradoxo epidemiológico da situação de saúde bucal da população brasileira. Posteriormente, são discutidas as contradições entre a formação do cirurgiã0-dentista e as exigências do referido Programa, avançando até as perspectivas proporcionadas pelo PSF quanto às oportunidades de emprego por ele criadas, questionando-se a compatibilidade entre a projeção de vagas a serem oferecidas e a quantidade de novos profissionais formados a cada ano. Por fim, procurou-se sintetizar a essência do que se abordou, através da construção de considerações finais acerca da inserção da odontologia no PSF e de suas repercussões sobre as condições de saúde bucal da população, a formação profissional e o mercado de trabalho.


Asunto(s)
Educación en Salud Dental , Salud Bucal , Salud Pública , Odontología en Salud Pública , Estrategias de Salud Nacionales
20.
Salvador; s.n; 2005. 128 p.
Tesis en Portugués | LILACS | ID: lil-498065

RESUMEN

O objetivo deste estudo foi analisar as representações sociais de uma equipe de saúde que trabalha em instituição socioeducativa de internação sobre os adolescentes internados. O marco teórico do estudo baseou-se nos trabalhos de Moscovi (2004) e autores como Volpi e Silva (2003), que permitiram refletir como essas representações repercutem na operacionalização da medida socioeducativa de internação e discutir a associação desta atenção integral a saúde compativel com a formação para a cidadania e a inclusão social dos adolescentes. Optou-se pela abordagem etnográfica na coleta de dados...


Asunto(s)
Masculino , Adolescente , Salud del Adolescente , Educación Continua , Salud del Adolescente Institucionalizado , Grupo de Atención al Paciente
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