Psycho-emotional status but not cognition is changed under the combined effect of ionizing radiations at doses related to deep space missions.

Human spaceflight launch is the big challenge that the humanity work on. The astronauts' task performance vulnerability to ionizing radiations is one of the major factors limiting deep space missions. In this work, we study the effect of ionizing radiations (γ-quanta and 12C6+ in combination) on cognitive abilities and psycho-emotional status of Wistar rats. Irradiation led to the hyperlocomotion, increase of anxiety-like behavior, suppression of depressive-like behavior and enhancement of spatial learning. These data are consistent with the neurochemical/molecular analysis: enhanced monoaminergic innervation within the hypothalamus (HYP), inhibition of serotonin turnover in the prefrontal cortex and neurokenin 1 receptor overexpression in the amygdala (AMY). In addition, we observe decreased expression of certain biomolecules in the AMY (5-HT2c and 5-HT3) and in the HYP (5-HT2a, 5-HT4 and VMAT2) that can be explained as neuroadaptive changes. Thus, the ionizing radiation exposure significantly modulates the psycho-emotional status. With that, for the first time we received data that radiation effects in the doses and composition of interplanetary space (in terrestrial modeling) could be relatively safe for cognitive functions.

[Body function and the biological aging of those working under the conditions of a warming microclimate]. / Funktsional'noe sostoianie organizma i biologicheskoe starenie rabotaiushchikh v usloviiakh nagrevaiushchego mikroklimata.

The state of the cardiovascular system, indices of thermoregulation, immunological reactivity, cardiopulmonary and biological age were investigated in workers of "hot" professions. It was established that persons working in conditions of heating microclimate show a weakening of the compensation capacities of the cardio-vascular system manifested in a reduction of tone of arterial vessels, inhibition of immunological reactivity. These workers revealed an increased rate of aging of the body at working length over 15 years.

[Results of studies on long-term results of the effects of hot microclimate on the body of workers]. / Nekotorye rezul'taty issledovanii otdalennykh éffektov vozdeistviia nagrevaiushchego mikroklimata na organism rabotaiushchikh.

The article presents data on the functional features of thermoregulation, cardiovascular and respiratory system, neuro-muscular and immune state in those engaged in heating microclimate labour conditions. It is proposed that intensive heat and physical overload results in presenilation among workers, which is proved by changes in their cardiopulmonary and biologic aging processes.