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1.
Urologiia ; (6): 95-101, 2023 Dec.
Artículo en Ruso | MEDLINE | ID: mdl-38156690

RESUMEN

INTRODUCTION: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are among the most common urological diseases in men. It has been repeatedly suggested that viral infection plays an important role in prostate carcinogenesis. AIM: To assess the relationship between viral infection and PCa, as well as the clinical and morphological features of BPH and PCa. MATERIALS AND METHODS: A total of 98 patients undergoing treatment for BPH (n=48) or PCa (n=50) between 2019 and 2021 were included in the study. Real-time PCR on the surgical specimens for human papillomaviruses (HPV), herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2), cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes virus type 6 (HSV-6) was performed. RESULTS: In patients with PCa, viruses in prostate tissue were found more often compared to those with BPH (50.0 vs. 31.3%, respectively, p=0.046.) The most common virus in both PCa and BPH was EBV (22.0 vs. 16.7%, respectively). The second most common virus in patients with PCa was HSV-6 (20.0%), which was not detected in any men with BPH (p=0.003). There was a trend toward higher prevalence of CMV among patients with PCa (16.0% vs. 4.2%), but the difference was not significant (p=0.09). There was no association of viral infection with clinical and morphological features. CONCLUSIONS: The resulting trend toward a higher prevalence of HSV-6 and CMV in patients with PCa compared to those with BPH creates the prerequisites for further study of viruses in prostate diseases involving a larger cohort, which will provide an idea of the multi-stage process of malignant transformation and, possibly, open new therapeutic options for prevention and treatment.


Asunto(s)
Infecciones por Citomegalovirus , Infecciones por Virus de Epstein-Barr , Infecciones por Papillomavirus , Hiperplasia Prostática , Neoplasias de la Próstata , Masculino , Humanos , Infecciones por Virus de Epstein-Barr/complicaciones , Infecciones por Virus de Epstein-Barr/epidemiología , Virus del Papiloma Humano , Herpesvirus Humano 4 , Hiperplasia Prostática/complicaciones , Hiperplasia Prostática/epidemiología , Neoplasias de la Próstata/epidemiología , Neoplasias de la Próstata/complicaciones , Citomegalovirus , Infecciones por Citomegalovirus/complicaciones , Infecciones por Citomegalovirus/epidemiología
2.
Urologiia ; (6): 145-150, 2023 Dec.
Artículo en Ruso | MEDLINE | ID: mdl-38156699

RESUMEN

Recurrent bladder neck sclerosis is one of the common complications of endoscopic treatment of benign prostate hyperplasia, which often leads to multiple re-operations, including complex open and laparoscopic reconstructive procedures. One of the most promising minimally invasive methods for preventing recurrence of bladder neck sclerosis is balloon dilatation under transrectal ultrasound guidance. To improve the results of using this technique, a urethral catheter with a biopolymer coating, capable of depositing a drug and eluting it under the influence of diagnostic ultrasound, was proposed.


Asunto(s)
Hiperplasia Prostática , Resección Transuretral de la Próstata , Obstrucción del Cuello de la Vejiga Urinaria , Masculino , Humanos , Próstata/patología , Resección Transuretral de la Próstata/métodos , Vejiga Urinaria/diagnóstico por imagen , Vejiga Urinaria/cirugía , Catéteres Urinarios/efectos adversos , Esclerosis/complicaciones , Esclerosis/patología , Hiperplasia/complicaciones , Hiperplasia/patología , Hiperplasia Prostática/complicaciones , Obstrucción del Cuello de la Vejiga Urinaria/complicaciones , Ultrasonografía , Resultado del Tratamiento
3.
Urologiia ; (3): 134-141, 2019 Jul.
Artículo en Ruso | MEDLINE | ID: mdl-31356027

RESUMEN

Benign prostatic hyperplasia (BPH) is one of the most common diseases of the genitourinary system. BPH prevalence increases in men with advancing age, highlighting the necessity of minimally invasive surgical procedure including super-selective prostatic artery embolization (PAE). The current role of the PAE for BPH treatment according to recent national and international publications is discussed in this review. The data from the largest studies are structured and presented along with our experience in PAE. In addition, a need to continue research on this topic is underlined.


Asunto(s)
Embolización Terapéutica , Hiperplasia Prostática , Humanos , Masculino , Hiperplasia Prostática/terapia , Resultado del Tratamiento , Procedimientos Quirúrgicos Vasculares
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