[Clinical and molecular correlation between chronic hepatitis and hepatocellular carcinoma induced by hepatitis B virus].

The role of X-gene of hepatitis B virus (HBV), telomerase gene, structural HBV proteins is considered. Both factors of the virus and those of the host are involved in hepatocarcinogenesis. The duration of chronic B hepatitis may influence mitogenic and mutagenic conditions for accumulation of occasional genetic and chromosomal damage and result in hepatocarcinoma development.

[Effect of "vilon" on cirrhotically changed rat liver. Liver regeneration, and status of glycogen-forming function of hepatocytes]. / Vliianie preparata "vilon" na tsirroticheski izmenennuiu pecheni krys. Regeneratsiia pecheni i sostoianie glikogenoobrazovatel'noi funktsii gepatotsitov.

Effects of a dipeptide preparation "Vilon" on rehabilitation of functional activity of hepatocytes and regeneration of the cirrhotically altered rat liver were studied. The liver cirrhosis was produced by poisoning of rats for 4 months with carbon tetrachloride (CCl4). On the end of the poisoning with CCl4, one group of animals was not submitted to any further actions, whereas animals of the other group were injected "Vilon" (1.7 micrograms/kg) daily for 5 days. On smears of isolated hepatocytes, contents of total glycogen (TG), and its labile and stable fractions (LF and SF) were determined in addition to cell ploidy levels and the total protein content. In liver homogenates, activities of glucose-6-phosphatase (G6P), glycogen synthase (GS), and glycogen phosphorylase (GP) were measured. In 2 weeks after the drug application, G6P activity being reduced in cirrhosis 1.2 times, elevated under effect of "Vilon". In non-treated rats the contents of TG and its fractions and of G6P activity remained at the level characteristic of the cirrhotic liver prior to "Vilon" administration. In both groups of rats, GP and GS activities in the cirrhotically altered liver did not differ from their control values throughout the entire experiment. "Vilon" has been shown to exert a weak stimulating effect on regeneration of the cirrotically altered rat liver: in hepatocytes of the second group of rats the total protein content and ploidy levels were higher than those in the first group by 4.7 and 11.5%, respectively.

[The sanitary hygiene conditions of the work and morbidity characteristics of workers in the sulfur industry]. / Sanitarno-gigienicheskie usloviia truda i osobennosti zabolevaemosti rabochikh sernogo proizvodstva.

Major forms of morbidity with temporary disability were studied in the professional groups of workers engaged in sulphur autoclave production. It was established that the morbidity rates increased depending on the age and length of service factors. There was neurosis-related morbidity with temporary, disability caused by the toxic action of the sulphur compounds on the health state. In workers with greater length of service disorders in the oxidation-reduction processes, statistically proved decrease of the sulfhydryl groups' contents in the blood and blood peroxidase activity suppression, were found. A set of measures was proposed towards health-related improvements of the labour conditions.

[Status and improvement in expert evaluation of temporary disability conducted by the therapeutic service]. / Sostoianie i sovershenstvovanie ékspertizy vremennoi netrudosposobnosti, osushchestvliaemoi terapevticheskoi sluzhboi.

The sociological approach was applied to study the organization and status of the expert medical evaluation of temporary disability of the therapeutic patients. 205 internists filled in self-administered questionnaires. 45.4% of those internists worked at the rural treatment and prophylactic institutions. The studies formed the basis for the development and introduction of a complex of scientifically validated measures aimed at further raising the standards of the expert medical evaluation of the working capacity at the medical institutions of the Lvov region of the Ukrainian SSR.