RESUMEN
The effects of impaza on ovulatory cycles, sexual behavior, and conception processes were studied in female rats. A two-week course of impaza in doses of 3 and 15 ml/kg did not affect alternation of estrous cycle phases, the incidence of estrus reducing. Sexual behavior of these females was characterized by activation of the receptive sexual motivations; conception was characterized by a higher fertility index and a lower fetal mortality.
Asunto(s)
Anticuerpos/farmacología , Ciclo Estral/efectos de los fármacos , Fármacos para la Fertilidad Femenina/farmacología , Fertilización/efectos de los fármacos , Aptitud Genética/efectos de los fármacos , Conducta Sexual Animal/efectos de los fármacos , Animales , Animales no Consanguíneos , Ciclo Estral/fisiología , Femenino , Fertilización/fisiología , Mortalidad Fetal , Aptitud Genética/fisiología , Libido/efectos de los fármacos , Tamaño de la Camada/efectos de los fármacos , Tamaño de la Camada/fisiología , Masculino , Embarazo , Ratas , Conducta Sexual Animal/fisiologíaRESUMEN
The results of a study of a new synthetic drug dimephosphon used as a pathogenetic means in the treatment of experimental tuberculosis are presented. Dimephosphon was found to be responsible for both the in vivo and in vitro decrease of the degree of MBT resistance to rifampicin. The findings of macroscopic, histologic and bacteriologic examinations demonstrated a significant increase in the effectiveness of antituberculous therapy. Dimephosphon monotherapy in mice elicited manifested stimulation of peritoneal macrophages: increase in O2- production, and decline in extracellular 5-nucleotidase activity. Nemolysine-synthetic cellular splenic activity in mice rose essentially. No direct stimulating influence of dimephosphon on functional macrophage activity in vitro was found.
Asunto(s)
Antituberculosos/administración & dosificación , Modelos Animales de Enfermedad , Isoniazida/administración & dosificación , Pulmón/efectos de los fármacos , Mycobacterium bovis/efectos de los fármacos , Compuestos Organofosforados/administración & dosificación , Tuberculosis Pulmonar/tratamiento farmacológico , Animales , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Evaluación Preclínica de Medicamentos , Quimioterapia Combinada , Técnicas In Vitro , Pulmón/microbiología , Ratones , Mycobacterium bovis/crecimiento & desarrollo , Tuberculosis Pulmonar/microbiologíaAsunto(s)
Hidroxibutiratos/uso terapéutico , Inosina/uso terapéutico , Levamisol/uso terapéutico , Oxibato de Sodio/uso terapéutico , Tuberculosis/tratamiento farmacológico , Animales , Evaluación Preclínica de Medicamentos , Quimioterapia Combinada , Inmunidad/efectos de los fármacos , Lactatos/sangre , Ratones , Ratones Endogámicos CBA , Mycobacterium bovis , Piruvatos/sangre , Conejos , Tuberculosis/sangre , Tuberculosis/inmunologíaAsunto(s)
Linfocitos T/inmunología , Tuberculosis/inmunología , Animales , Femenino , Inmunidad Innata , Ratas , TimectomíaRESUMEN
The effects were studied of the degree of immunodeficiency produced by thymectomy of one-month-old rats on the course of experimental tuberculosis induced 3, 6 and 9 months after thymectomy. Subject to study was also the effect of immunodeficiency correction with thymalin on the tuberculous process. It was established that the lungs of thymectomized rats infected 9 months after the thymectomy were damaged more severely as compared with control or thymalin-treated animals. In thymectomized rats treated with thymalin, the absolute content of medium-sized and big lymphocytes in peripheral blood was found to be lower, the content of small lymphocytes being unchanged throughout all observation periods. The time course of migration activity (spontaneous and in response to PPD) in rats treated with thymalin corresponded with the time course in controls in contrast to thymectomized rats which did not receive the treatment. The results indicate that tuberculosis severity depends on the degree of immunodeficiency and that the functional properties of immunocompetent cells may be corrected with thymalin.