1.
Acta Pharmaceutica Sinica B
; (6): 1629-1647, 2021.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-888825
RESUMEN
Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction. Lipid mediators orchestrate both the initiation and resolution of inflammation. Switching from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation, though drug candidates exhibiting such features are unknown. Starting from a library of Vietnamese medical plant extracts, we identified isomers of the biflavanoid 8-methylsocotrin-4'-ol from