RESUMEN
OBJECTIVE: To study the influence on the neonate of indomethacin administered to the mother as an additional tocolytic. STUDY DESIGN: The neonatal outcome in 76 closely matched low birth weight infants was compared retrospectively: those whose mothers received indomethacin together with betamimetics formed the study group, those whose mothers received only betamimetics formed the control group. RESULTS: There was an increased incidence of respiratory distress syndrome (RDS) in the study group (97% versus 45%; P<0.001), an increased need for surfactant use (68% versus 26%; P<0.001) and increased ventilatory support, and an increased incidence of bronchopulmonary dysplasia (BPD) (47% versus 24%; P=0.03). Gestation could not be prolonged significantly by the addition of indomethacin. CONCLUSION: Indomethacin as an additional tocolytic agent was associated with an increased incidence of RDS, surfactant use and BPD but did not significantly prolong gestation.
Asunto(s)
Rotura Prematura de Membranas Fetales/tratamiento farmacológico , Indometacina/uso terapéutico , Recién Nacido de Bajo Peso/fisiología , Trabajo de Parto/efectos de los fármacos , Respiración/efectos de los fármacos , Tocolíticos/uso terapéutico , Agonistas Adrenérgicos beta/uso terapéutico , Displasia Broncopulmonar/inducido químicamente , Estudios de Cohortes , Femenino , Humanos , Incidencia , Indometacina/administración & dosificación , Indometacina/efectos adversos , Recién Nacido , Modelos Logísticos , Embarazo , Resultado del Embarazo , Síndrome de Dificultad Respiratoria del Recién Nacido/inducido químicamente , Síndrome de Dificultad Respiratoria del Recién Nacido/epidemiología , Estudios Retrospectivos , Ritodrina/uso terapéutico , Tocolíticos/administración & dosificación , Tocolíticos/efectos adversosAsunto(s)
Factor Estimulante de Colonias de Granulocitos/efectos adversos , Cefalea/inducido químicamente , Trastornos de la Visión/inducido químicamente , Adulto , Viscosidad Sanguínea/efectos de los fármacos , Filgrastim , Humanos , Leucocitosis/inducido químicamente , Masculino , Proteínas RecombinantesRESUMEN
Botryomycosis is an atypical reaction of the host to a common bacterial infection. A case of botryomycosis mimicking a liposarcoma as suspected on clinical and radiological grounds is described. The diagnosis was made by biopsy and culture of the lesion. A review of the literature is given.
Asunto(s)
Infecciones por Escherichia coli/diagnóstico , Escherichia coli/aislamiento & purificación , Liposarcoma/diagnóstico , Infecciones de los Tejidos Blandos/diagnóstico , Abdomen , Adulto , Diagnóstico Diferencial , Infecciones por Escherichia coli/patología , Femenino , Granuloma/diagnóstico , Granuloma/patología , Humanos , Liposarcoma/patología , Infecciones de los Tejidos Blandos/patologíaRESUMEN
During 1981 to mid-1988 three cases of anaphylactic shock after treatment with the quinolone derivative cinoxacin were reviewed by the Netherlands Centre for Monitoring of Adverse Reactions to Drugs and 17 cases of an anaphylactic type of reaction notified to the World Health Organisation Collaborating Centre for International Drug Monitoring. In five out of six patients for whom data were available the reaction began shortly after taking a single capsule of a second or next course of treatment. Cinoxacin is related to nalidixic acid, and one patient previously treated with that agent subsequently had an anaphylactoid reaction to cinoxacin and later developed a skin reaction to nalidixic acid. There were no deaths, and patients treated as an emergency with plasma expanders or with adrenaline and corticosteroids generally recovered promptly and uneventfully. In view of the potentially fatal consequences of anaphylactic reactions to cinoxacin and other quinolones doctors should take care when prescribing these drugs.