RESUMEN
OBJECTIVE: To assess the effect of white petrolatum vs bacitracin ointment on wound infection incidence, allergic contact dermatitis incidence, and healing characteristics. DESIGN: Randomized, double-blind, prospective trial comparing white petrolatum with bacitracin ointment in postprocedure wound care. SETTING: A general outpatient dermatology clinic and a tertiary referral advanced surgical procedure clinic at Walter Reed Army Medical Center, Washington, DC. PATIENTS: A total of 922 patients who had dermatologic surgery with a total of 1249 wounds. MAIN OUTCOME MEASURES: The incidence of infection and allergic contact dermatitis during a follow-up period of 4 weeks. Healing characteristics were secondary outcomes. RESULTS: Of the 922 patients enrolled, 440 in the white petrolatum group and 444 in the bacitracin group were evaluable for clinical response. The 2 treatment groups had comparable baseline characteristics. Thirteen patients developed postprocedure infection (1.5%), 9 (2.0%) in the white petrolatum group vs 4 (0.9%) in the bacitracin group (95% confidence interval for difference, -0.4% to 2.7%; P=.37). Eight infections (1.8%) in the white petrolatum group were due to Staphylococcus aureus vs none in the bacitracin group (P=.004). No patient in the group using white petrolatum developed allergic contact dermatitis vs 4 patients (0.9%) in the group using bacitracin (P=.12). Additionally, there were no clinically significant differences in healing between the treatment groups on day 1 (P=.98), day 7 (P=.86), or day 28 (P=.28) after the procedure. CONCLUSIONS: White petrolatum is a safe, effective wound care ointment for ambulatory surgery. In comparison with bacitracin, white petrolatum possesses an equally low infection rate and minimal risk for induction of allergy.
Asunto(s)
Procedimientos Quirúrgicos Ambulatorios , Antiinfecciosos Locales/uso terapéutico , Bacitracina/uso terapéutico , Dermatitis Alérgica por Contacto/epidemiología , Vaselina/uso terapéutico , Enfermedades de la Piel/cirugía , Infección de la Herida Quirúrgica/epidemiología , Adulto , Anciano , Procedimientos Quirúrgicos Ambulatorios/economía , Procedimientos Quirúrgicos Ambulatorios/estadística & datos numéricos , Antiinfecciosos Locales/economía , Bacitracina/economía , Análisis Costo-Beneficio , Dermatitis Alérgica por Contacto/economía , Dermatitis Alérgica por Contacto/etiología , Método Doble Ciego , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Vaselina/economía , Cuidados Posoperatorios , Estudios Prospectivos , Infección de la Herida Quirúrgica/economía , Infección de la Herida Quirúrgica/prevención & control , Cicatrización de Heridas/efectos de los fármacosRESUMEN
A flood of new knowledge and discoveries in the basic science of keratins and keratinization has appeared in the past several years. This review summarizes this recent information with a focus on the epithelial keratin polypeptides, keratin intermediate filaments, keratohyaline granule proteins, cell envelope formation and cell envelope proteins, "soft" keratinization, true disorders of keratinization (i.e., epidermolysis bullosa simplex and epidermolytic hyperkeratosis), and disease and drug effects on keratinization.
Asunto(s)
Queratinas/fisiología , Adulto , Animales , Betametasona/farmacología , Células Cultivadas , Ciclosporina/farmacología , Epidermólisis Ampollosa Simple/etiología , Humanos , Hiperqueratosis Epidermolítica/etiología , Queratinas/análisis , Queratinas/química , Queratinas/clasificación , Retinoides/farmacología , Piel/química , Piel/efectos de los fármacos , Piel/embriología , Enfermedades de la Piel/patología , Enfermedades de la Piel/fisiopatología , Cicatrización de Heridas/fisiologíaRESUMEN
Transmembrane channels have been found in the membrane fraction of corn (Zea mays W64AN) mitochondria that exhibit a remarkable resemblance to the voltage dependent anion-selective channels (VDAC) located in the outer membrane of animal (Rattus norvegicus), protist (Paramecium aurelia), and fungal (Neurospora crassa) mitochondria. The channels in corn were demonstrated to be essentially identical to VDAC channels in three characteristic properties: (a) single channel conductance magnitude, (b) weak anion selectivity, and (c) nature of voltage dependence. These findings led us to conclude that the channels present in corn mitochondria are VDAC channels. This discovery may have repercussions concerning the regulation and function of higher plant mitochondria, and the causation of higher plant excitability.