RESUMEN
Using a standard quantity of Re-186 HEDP, for therapy of osseous metastases from carcinoma of the breast, Palmedo and associates reported leukocyte and thrombocyte responses at 4 and 8 weeks. These were analyzed by dividing results into categories, based on the numeric initial values. Thrombocytes at 8 weeks exceeded pretreatment values in 10 of 18 cases. This "over-rebound" was also found in 7 of 19 leukocyte responses. The ability to predict thrombocyte-leukocyte response, in most cases, was linked to the initial hematologic values. If coupled with data on the status of bone marrow, this may allow the quantity of therapeutic radiopharmaceutical used to be increased or decreased without irreversibly compromising hematopoietic responses.
Asunto(s)
Plaquetas/efectos de la radiación , Neoplasias Óseas/secundario , Carcinoma/secundario , Ácido Etidrónico/uso terapéutico , Leucocitos/efectos de la radiación , Leucopenia/clasificación , Compuestos Organometálicos/uso terapéutico , Radiofármacos/uso terapéutico , Renio/uso terapéutico , Trombocitopenia/clasificación , Radioisótopos de Estaño/uso terapéutico , Médula Ósea/efectos de la radiación , Neoplasias Óseas/radioterapia , Neoplasias de la Mama/patología , Carcinoma/radioterapia , Ácido Etidrónico/administración & dosificación , Femenino , Estudios de Seguimiento , Predicción , Humanos , Recuento de Leucocitos , Leucopenia/fisiopatología , Compuestos Organometálicos/administración & dosificación , Recuento de Plaquetas , Radiofármacos/administración & dosificación , Renio/administración & dosificación , Trombocitopenia/fisiopatología , Radioisótopos de Estaño/administración & dosificaciónAsunto(s)
Enfermedades de la Mama/diagnóstico por imagen , Neoplasias de la Mama/diagnóstico por imagen , Enfermedad de Paget Mamaria/diagnóstico por imagen , Psoriasis/diagnóstico por imagen , Diagnóstico Diferencial , Femenino , Humanos , Persona de Mediana Edad , Pezones/diagnóstico por imagen , Cintigrafía , Tecnecio Tc 99m SestamibiAsunto(s)
Hígado/diagnóstico por imagen , Adulto , Citratos/farmacocinética , Diagnóstico Diferencial , Femenino , Galio/farmacocinética , Radioisótopos de Galio/farmacocinética , Enfermedad de Hodgkin/patología , Enfermedad de Hodgkin/cirugía , Humanos , Hígado/patología , Estadificación de Neoplasias , Cintigrafía , Radiofármacos/farmacocinética , Esplenectomía/efectos adversos , Tomografía Computarizada por Rayos XAsunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Linfoma de Células B Grandes Difuso/diagnóstico por imagen , Neoplasias del Bazo/diagnóstico por imagen , Estudios de Seguimiento , Radioisótopos de Galio , Humanos , Linfoma de Células B Grandes Difuso/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia/diagnóstico por imagen , Recurrencia Local de Neoplasia/tratamiento farmacológico , Cintigrafía , Radiofármacos , Inducción de Remisión , Neoplasias del Bazo/tratamiento farmacológicoRESUMEN
A 45-year-old man, seropositive for hepatitis C, was examined because his liver was palpable well below the costal margin. A CT examination revealed multiple nodules within the liver and also several sites of ectopic tissue. The patient had a splenectomy 25 years before. A radiocolloid study showed uptake, consistent with splenosis, in the thorax, abdomen, pelvis, and possibly the left arm. The magnitude of the ectopic tissue, and its multiple locations, indicated the ability of splenic cells to grow in a variety of body sites.
Asunto(s)
Esplenosis/diagnóstico por imagen , Humanos , Hígado , Masculino , Persona de Mediana Edad , Cintigrafía , Radiofármacos , Esplenectomía , Azufre Coloidal Tecnecio Tc 99m , Factores de Tiempo , Tomografía Computarizada por Rayos XRESUMEN
A 75-yr-old glucocorticoid-dependent asthmatic male had a bone mineral density study to assess possible osteoporosis prior to initiating therapy. A radiograph of the lumbar spine revealed an asymmetrical compression of the second lumbar vertebra, marked scoliosis, vertebral osteopenia, and a highly calcified abdominal aorta. Bone mineral density (dual X-ray absolptiometry [DXA]) revealed low bone mass in L2-L4 and a markedly abnonrnal pattern, with a linear central density representing a calcified aorta. Posterior-anterior measurements of the midlumbar region with and without the overlying aorta indicated that the calcified vessel contributed up to 33% of the measured density. This was a far higher contribution than reported in other studies. Lateral DXA measurements of the L2 vertebra and the overlying aorta were performed to validate this finding. The density of the L2 vertebra was 0.215 g/cm(2), and that of the overlying calcified aorta was 0. 210 g/cm(2). This case suggests that aortic calcifications may contribute sign)ficantly to overall lumbar bone density and, unless recognized, can inadvertently lead to misclassification of osteoporosis.