Asunto(s)
Coriorretinitis/diagnóstico , Infecciones Parasitarias del Ojo/diagnóstico , Timoma/patología , Neoplasias del Timo/patología , Toxoplasmosis Ocular/diagnóstico , Anticuerpos Antiprotozoarios/sangre , Coriorretinitis/parasitología , ADN Protozoario/análisis , Infecciones Parasitarias del Ojo/parasitología , Femenino , Humanos , Hipergammaglobulinemia/diagnóstico , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Tomografía de Emisión de Positrones , Timoma/diagnóstico por imagen , Neoplasias del Timo/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Toxoplasmosis Ocular/parasitología , Agudeza Visual , Cuerpo Vítreo/parasitologíaRESUMEN
Currently, up to 50% of the operations in early-stage non-small cell lung cancer (NSCLC) are futile owing to the presence of locally advanced tumour or distant metastases. More accurate pre-operative staging is required in order to reduce the number of futile operations. The cost-effectiveness of fluorine-18 fluorodeoxyglucose positron emission tomography ((18)FDG-PET) added to the conventional diagnostic work-up was studied in the PLUS study. Prior to invasive staging and/or thoracotomy, 188 patients with (suspected) NSCLC were randomly assigned to conventional work-up (CWU) and whole-body PET or to CWU alone. CWU was based on prevailing guidelines. Pre-operative staging was followed by 1 year of follow-up. Outcomes are expressed in the percentage of correctly staged patients and the associated costs. The cost price of PET varied between
Asunto(s)
Carcinoma de Pulmón de Células no Pequeñas/diagnóstico por imagen , Carcinoma de Pulmón de Células no Pequeñas/economía , Análisis Costo-Beneficio/métodos , Fluorodesoxiglucosa F18/economía , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/economía , Tomografía Computarizada de Emisión/economía , Anciano , Carcinoma de Pulmón de Células no Pequeñas/diagnóstico , Femenino , Costos de la Atención en Salud/estadística & datos numéricos , Humanos , Neoplasias Pulmonares/diagnóstico , Masculino , Estadificación de Neoplasias/economía , Estadificación de Neoplasias/métodos , Países Bajos , Radiofármacos/economía , Reproducibilidad de los Resultados , Medición de Riesgo/economía , Medición de Riesgo/métodos , Sensibilidad y Especificidad , Tomografía Computarizada de Emisión/métodosRESUMEN
BACKGROUND: Up to 50% of curative surgery for suspected non-small-cell lung cancer is unsuccessful. Accuracy of positron emission tomography (PET) with 18-fluorodeoxyglucose (18FDG) is thought to be better than conventional staging for diagnosis of this malignancy. Up to now however, there has been no evidence that PET leads to improved management of patients in routine clinical practice. We did a randomised controlled trial in patients with suspected non-small-cell lung cancer, who were scheduled for surgery after conventional workup, to test whether PET with 18FDG reduces number of futile thoracotomies. METHODS: Before surgery (mediastinoscopy or thoracotomy), 188 patients from nine hospitals were randomly assigned to either conventional workup (CWU) or conventional workup and PET (CWU+PET). Patients were followed up for 1 year. Thoracotomy was regarded as futile if the patient had benign disease, explorative thoracotomy, pathological stage IIIA-N2/IIIB, or postoperative relapse or death within 12 months of randomisation. The primary outcome measure was futile thoracotomy. Analysis was by intention to treat. FINDINGS: 96 patients were randomly assigned CWU and 92 CWU+PET. Two patients in the CWU+PET group did not undergo PET. 18 patients in the CWU group and 32 in the CWU+PET group did not have thoracotomy. In the CWU group, 39 (41%) patients had a futile thoracotomy, compared with 19 (21%) in the CWU+PET group (relative reduction 51%, 95% CI 32-80%; p=0.003). INTERPRETATION: Addition of PET to conventional workup prevented unnecessary surgery in one out of five patients with suspected non-small-cell lung cancer.