Cubic and Sphere Magnetic Nanoparticles for Magnetic Hyperthermia Therapy: Computational Results.

Magnetic nanoparticles (MNPs) with various shapes and special (magnetic and thermal) properties are promising for magnetic hyperthermia. The efficiency of this therapy depends mainly on the MNPs' physical characteristics: types, sizes and shapes. This paper presents the hyperthermic temperature values induced by cubic/sphere-shaped MNPs injected within a concentric tissue configuration (malignant and healthy tissues) when an external time-dependent magnetic field was applied. The space-time distribution of the nanoparticles as a result of their injection within a tumoral (benign/malign) tissue was simulated with the bioheat transport equation (Pennes equation). A complex thermo-fluid model that considers the space-time MNP transport and its heating was developed in Comsol Multiphysics. The cubic-shaped MNPs give a larger spatial distribution of the therapeutic temperature in the tumoral volume compared to the spherical-shaped ones. MNP doses that induce the therapeutic (hyperthermic) values of the temperature (40 ÷ 45 °C) in smaller volumes from the tumoral region were analyzed. The size of these regions (covered by the hyperthermic temperature values) was computed for different magnetite cubic/sphere-shaped MNP doses. Lower doses of the cubic-shaped MNPs give the hyperthermic values of the temperature in a larger volume from the tumoral region compared with the spheric-shaped MNPs. The MNP doses were expressed as a ratio between mass concentration and the maximum clinical accepted doses. This thermo-fluid analysis is an important computational instrument that allows the computations of the MNP doses that give therapeutic temperature values within tissues.

Antifragility as a complex system's response to perturbations, volatility, and time.

Antifragility characterizes the benefit of a dynamical system derived from the variability in environmental perturbations. Antifragility carries a precise definition that quantifies a system's output response to input variability. Systems may respond poorly to perturbations (fragile) or benefit from perturbations (antifragile). In this manuscript, we review a range of applications of antifragility theory in technical systems (e.g., traffic control, robotics) and natural systems (e.g., cancer therapy, antibiotics). While there is a broad overlap in methods used to quantify and apply antifragility across disciplines, there is a need for precisely defining the scales at which antifragility operates. Thus, we provide a brief general introduction to the properties of antifragility in applied systems and review relevant literature for both natural and technical systems' antifragility. We frame this review within three scales common to technical systems: intrinsic (input-output nonlinearity), inherited (extrinsic environmental signals), and interventional (feedback control), with associated counterparts in biological systems: ecological (homogeneous systems), evolutionary (heterogeneous systems), and interventional (control). We use the common noun in designing systems that exhibit antifragile behavior across scales and guide the reader along the spectrum of fragility-adaptiveness-resilience-robustness-antifragility, the principles behind it, and its practical implications.

Differential Graphical Games for Constrained Autonomous Vehicles Based on Viability Theory.

This article proposes an optimal-distributed control protocol for multivehicle systems with an unknown switching communication graph. The optimal-distributed control problem is formulated to differential graphical games, and the Pareto optimum to multiplayer games is sought based on the viability theory and reinforcement learning techniques. The viability theory characterizes the controllability of a wide range of constrained nonlinear systems; and the viability kernel and the capture basin are the pillars of the viability theory. The capture basin is the set of all initial states, in which there exist control strategies that enable the states to reach the target in finite time while remaining inside a set before reaching the target. In this regard, the feasible learning region is characterized by the reinforcement learner. In addition, the approximation of the capture basin provides the learner with prior knowledge. Unlike the existing works that employ the viability theory to solve control problems with only one agent and differential games with only two players, the viability theory, in this article, is utilized to solve multiagent control problems and multiplayer differential games. The distributed control law is composed of two parts: 1) the approximation of the capture basin and 2) reinforcement learning, which are computed offline and online, respectively. The convergence properties of the parameters' estimation errors in reinforcement learning are proved, and the convergence of the control policy to the Pareto optimum of the differential graphical game is discussed. The guaranteed approximation results of the capture basin are provided and the simulation results of the differential graphical game are provided for multivehicle systems with the proposed distributed control policy.

Ferroelectric Control of Magnetism in Ultrathin HfO2\Co\Pt Layers.

The recent demonstration of ferroelectricity in ultrathin HfO2 has kickstarted a new wave of research into this material. HfO2 in the orthorhombic phase can be considered the first and only truly nanoscale ferroelectric material that is compatible with silicon-based nanoelectronics applications. In this article, we demonstrate the ferroelectric control of the magnetic properties of cobalt deposited on ultrathin aluminum-doped, atomic layer deposition-grown HfO2 (tHfO2 = 6.5 nm). The ferroelectric effect is shown to control the shape of the magnetic hysteresis, quantified here by the magnetic switching energy. Furthermore, the magnetic properties such as the remanence are modulated by up to 41%. We show that this modulation does not only correlate with the charge accumulation at the interface but also shows an additional component associated with the ferroelectric polarization switching. An in-depth analysis using first order reversal curves shows that the coercive and interaction field distributions of cobalt can be modulated up to, respectively, 5.8% and 10.5% with the ferroelectric polarization reversal.

Reversible and Irreversible Processes in Drying and Wetting of Soil.

In this article, we provide a detailed description of a modeling technique for the capillary hysteresis in a soil-like porous material based on a Generalized Preisach Model. The identification of the reversible and irreversible Preisach distributions was performed with the first-order reversal curve (FORC) diagram technique, which is very popular now in magnetism and in other areas of science to give a fingerprint of the studied system. A special attention was given to the evaluation of the reversible component. In this case, we used a set of data published in 1965 by Morrow and Harris which has been used as a reference by many other researchers since. The advantage of this approach is that the experimental FORC distributions can be described with analytical functions and easily implemented in the mentioned Preisach-type model. Our research is also focused on the development of a characterization tool for the soil using the soil-moisture hysteresis. The systematic use of scanning curves provides a (FORC) diagram linked to the physical properties of the studied soil. The agreement between the experimental data and the Preisach model using the set of parameters found through the FORC technique is really noticeable and gives a good practical option to the researchers to use a method with a strong predictive capability.

Elastically driven cooperative response of a molecular material impacted by a laser pulse.

Photoinduced phase transformations occur when a laser pulse impacts a material, thereby transforming its electronic and/or structural orders, consequently affecting the functionalities. The transient nature of photoinduced states has thus far severely limited the scope of applications. It is of paramount importance to explore whether structural feedback during the solid deformation has the capacity to amplify and stabilize photoinduced transformations. Contrary to coherent optical phonons, which have long been under scrutiny, coherently propagating cell deformations over acoustic timescales have not been explored to a similar degree, particularly with respect to cooperative elastic interactions. Herein we demonstrate, experimentally and theoretically, a self-amplified responsiveness in a spin-crossover material during its delayed volume expansion. The cooperative response at the material scale prevails above a threshold excitation, significantly extending the lifetime of photoinduced states. Such elastically driven cooperativity triggered by a light pulse offers an efficient route towards the generation and stabilization of photoinduced phases in many volume-changing materials.

WIDEN: A tool for medical image management in multicenter clinical trials.

Background It has been proposed that in clinical trials in which the therapeutic strategy is driven by functional imaging, central review of the images should be done in real time. Purpose We report our experience with a new tool for image exchange and review, called Web-Based Imaging Diagnosis by Expert Network (WIDEN), which we implemented for the HD0607 prospective multicenter Italian clinical trial in which Hodgkin lymphoma treatment was adapted based on results of an interim positron emission tomography (PET) scan performed after the first two cycles of chemotherapy. Methods We used WIDEN for general management of the clinical trial, site imaging qualification, image exchange, workflow control, blinded independent central review, inter-observer variability assessment, consensus creation, audit, and statistical analysis. Results As of February 2013, the interim PET was available for 512 patients; upon central review, 103 of the scans were judged to be positive and 409 to be negative. The median scan uploading and downloading times were 1 min, 25 s and 1 min, 55 s, respectively; the average and median times for diagnosis exchange were 47 h, 53 min and 37 h, 43 min, respectively. The binary concordance between pairs of reviewers (Cohen's kappa) ranged from 0.72 to 0.85. The 5-point scale concordance among all reviewers (Krippendorf's alpha) was 0.77. Conclusions WIDEN proved to be an effective tool for medical imaging exchange and online review. Data security, simplicity, feasibility, and prompt scan review were demonstrated. Central reviews were completed promptly.

Mean field model for ferromagnetic nanowire arrays based on a mechanical analogy.

Nanowire arrays have typical distributions of coercive and interaction fields, as revealed in experiments by means of the first-order reversal curve (FORC) method. In an axial applied field, each nanowire is subjected to a state dependent interaction field created by all wires from the array, which strongly influences the switching fields. A mean field model based on Preisach-Krasnosel'skii-Pokrovskii (PKP) hysterons is able to explain the interplay between interactions and critical fields in nanowire arrays and the subtle way in which switching fields are emphasized in FORC diagrams.

Magnetic α-Fe2O3/MCM-41 nanocomposites: preparation, characterization, and catalytic activity for methylene blue degradation.

Catalysts based on nanosized magnetic iron oxide stabilized inside the pore system of ordered mesoporous silica MCM-41 have been prepared. The obtained materials were characterized by powder X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), vibrating sample magnetometer (VSM), and N(2) adsorption-desorption isotherm. XRD analysis showed that the obtained materials consist from the pure hematite crystalline phase (α-Fe(2)O(3)) dispersed within ordered mesoporous silica MCM-41. Magnetic measurements show that the obtained nanocomposites exhibit at room temperature weak ferromagnetic behavior with slender hysteresis. The catalytic activity of the magnetic α-Fe(2)O(3)/MCM-41 nanocomposites was evaluated by the degradation of methylene blue (MB) aqueous solution. For this purpose, an ultrasound-assisted Fenton-like process was used. The effect of solution pH on degradation of MB was investigated. The results indicated that US-H(2)O(2)-α-Fe(2)O(3)/MCM-41 nanocomposite system is effective for the degradation of MB, suggesting its great potential in removal of dyes from wastewater. It was found that the degradation rate of MB increases with decrease in the pH value of the solution.

Analytical vector generalization of the classical Stoner-Wohlfarth hysteron.

In view of the difficulties in using the well-known Stoner-Wohlfarth (SW) ferromagnetic single-domain particle as a vector hysteresis unit in statistical models of hysteresis like the Preisach-type model or in micromagnetic models, we propose a new description of the single-domain ferromagnetic grains by using a vector hysteron (VH) as the 2D and 3D generalization of the rectangular hysteron. The vector hysteron introduced from magnetic symmetry considerations describes analytically the properties of a range of single-domain ferromagnetic particles and also provides the physical motivation for the linear form of the energy barrier used in several dynamic models. In this paper we show the main characteristics of the analytical vector hysteron by comparing it with the well-known Stoner-Wohlfarth model. We compare the hysteresis curves, switching fields and energetic properties of the uniaxial single-domain particles as provided by the two models.

Model for elastic relaxation phenomena in finite 2D hexagonal molecular lattices.

The relaxation in a spin transition compound is modeled on the basis of molecules interacting by the way of connecting springs and situated in a bidimensional open boundary hexagonal lattice. The switch of individual molecules is randomly checked using a standard Monte Carlo procedure. The switching probability depends on the energy gap between the two states in the absence of interactions and on the elongations of the nearest springs. The main characteristics of the experimental relaxation curves are reproduced and clustering and nucleation phenomena are detected.

Nonlinear system identification based on internal recurrent neural networks.

A novel approach for nonlinear complex system identification based on internal recurrent neural networks (IRNN) is proposed in this paper. The computational complexity of neural identification can be greatly reduced if the whole system is decomposed into several subsystems. This approach employs internal state estimation when no measurements coming from the sensors are available for the system states. A modified backpropagation algorithm is introduced in order to train the IRNN for nonlinear system identification. The performance of the proposed design approach is proven on a car simulator case study.

Transverse susceptibility method in nanoparticulate magnetic media.

Transverse susceptibility (TS) method is a reliable method for the determination of anisotropy in nanoparticulate media. To correctly evaluate the value of anisotropy in various modern nanostructured materials, a number of theoretical problems related to the method have to be well understood to avoid significant systematic errors. This paper presents the state of the art in the TS method which includes the expression for single domain particles with any type of anisotropy, the theoretical and micromagnetic, using Landau-Lifshitz-Gilbert (LLG) equation and stochastic LLG equation studies of the effects of ac field amplitude, inter-particle interactions, and magnetic relaxation. The problem of both real and imaginary parts of the TS signal is also discussed.

Predicting severity of foreign body injuries in children in upper airways: an approach based on regression trees.

The entry of a small item into the upper airways is one of the leading causes of injuries in children up to 14 years old. The aim of this study is to characterize types of objects causing choking along with the features of the children involved in the accident and compare results with current standards. The European Survey on Foreign Bodies Injuries Study (ESFBI) collected data on foreign body injuries from 19 European countries. The data from ESFBI were selected according to the ICD-9-CM codes 933 (foreign body in the pharynx and larynx) and 934 (foreign body in the trachea, bronchi, and lungs). Both a classification tree and a linear discriminant analysis (LDA) have been set up to predict the probability that an injured child experiences a hospitalization. The classification tree provides flowchart-type decision rules and allows for analyzing the impact of the item features, the children characteristics, and the circumstances of the accidents on the severity of the foreign body injuries. Results showed that children younger than 3.5 who are involved in an accident have a high probability to experience a hospitalization.