[The Stein-Leventhal syndrome with obesity]. / Prouchvaniia vurkhu sindroma na Stein-Leventhal sus zatlustiavane.

The authors carried out studies on 28 women with the syndrome of Stein-Leventhal with obesity. It was established that patients with hypothalamic genuine obesity of III degree predominated. The number of patients with liver steatosis was the largest among accompanying metabolic disturbances, followed by those with arterial hypertension and asymptomatic hyperuricemia. Menarche occurred on time, but it was succeeded by various menstrual disturbances. There was increased level of testosterone in sera of 12 out of 20 examined women patients, of LH-in 17, of 17-ketosteroids-in 8, of estrogens-in 6, of prolactin-in 8 patients. These data in parallelism between menstrual disturbances and hirsutism were interpreted by the authors as an expression of primary disturbances in hypothalamic-hypophysial-gonadal interrelationships with secondary changes in the ovaries. The role of fatty tissue in the metabolism of steroid hormones is discussed as well as the possibility for participation of genetic factors in the development of the syndrome of Stein-Leventhal and obesity.

[Study of anorexia nervosa]. / Prouchvaniia vurkhu nervnata anoreksiia.

18 women suffering from nervous anorexia were studied. The onset of the disease was before the age of 25 years in all patients. The loss of body mass was between 25% and 40%, mean 32%. The onset of the disease was preceded by psychic trauma, negative attitude toward eating, in some cases there had been periods of bulimia, use of purgatives and diuretics. All patients had amenorrhea. In 44.44% of the patients hypercholesterolemia was found, in 72.80%-hypertriglyceridemia, in 54.54%--increased somatotropic hormone level, in 54.54%--increased ACTH level, in 72.80%, decrease of follicle-stimulating hormone level, in 81.80%--decrease of the luteinizing hormone, in 81.80%--decrease of triiodothyronine (T3), in 81.80%--decrease of estradiol and in 81.80%--increase of testosterone were found. The deviations found in the patients with nervous anorexia are considered as manifestations of chronic food deficiency and they disappear after regaining the normal body mass.

[Sjögren's syndrome]. / Vurkhu sindroma na Sjögren.

A case of a woman who complained of dryness of the mouth, eyes and lack of tears is presented. For the diagnosis traditional tests were used--Schirmer's test, gastric intubation, as well as modern immunologic methods--immunoglobulins of single-chain and natural anti-DNA antibodies, radioscintigraphy of the salivary glands. The positive Schirmer's test, the slow gastric secretion with normal secretion at the lower normal range, the positive natural and anti DNA antibodies with increased IgA, IgG, IgM, and the data of the radioscintigraphy of the salivary glands make an early diagnosis possible and facilitate a timely modern treatment.

[Functional state of the genital system in men with obesity]. / Funktsionalno sustoianie na polovata sistema u muzhe sus zatlustiavane.

The results from the carried out investigations on fertility indices of ejaculate are reported as well as on the spermatogenic activity test with radioactive phosphorus and on the determination of total gonadotropic excretion in urine of males with high degree of obesity. A statistically significant decrease of all investigated in dices of ejaculate and the test of spermatogenic activity was found. The decreased gonadotropic activity in over half of the patients investigated with obesity, as well as the manifestations of diencephalic alterations in them made the authors admit the secondary character of the gonad disorders.