1.
Chem Commun (Camb)
; 59(93): 13843-13846, 2023 Nov 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37921487
RESUMEN
An NAD+ featuring an adenosyl 4'-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD+ with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.