RESUMEN
The leucine rich repeat containing 3B (LRRC3B) gene is a putative tumor suppressor located on human chromosome 3 in the 3p24 region. LRRC3B is frequently altered in colon and gastric cancers and also in leukaemias. In this study we investigated the promoter region methylation as a possible mechanism of LRRC3B gene inactivation in clear cell renal cell carcinomas. We found that the LRRC3B gene promoter was methylated in 43% of clear cell renal carcinoma samples. However, no correlation between DNA methylation and LRRC3B expression was found.
Asunto(s)
Carcinoma de Células Renales/genética , Carcinoma de Células Renales/fisiopatología , Metilación de ADN , Neoplasias Renales/genética , Proteínas de Neoplasias/genética , Proteínas de Neoplasias/metabolismo , Regiones Promotoras Genéticas , Humanos , Estadificación de NeoplasiasRESUMEN
OBJECTIVES: The aim of this study was to explore the impact of male prostatic symptoms on their partners' quality of life, daily routines and family relationships. METHODS: A structured telephone interview study was carried out on a random sample of 215 of the wives and partners of men aged 50 years or older drawn from those registered at four family medicine centres in Israel. They were asked about sleep disturbances, number of night-time wakings, and the effect on sexual relations, travel, entertainment, family and social relationships. RESULTS: The vast majority of women (86%) were affected by their partners' prostatism, with multiple consequences for their daily routines, quality of life and relationships. Sleep was the area of greatest concern, with 46% of women regularly waking due to their partners' urination disorder. The women reported other limitations: 37% noted problems with sexual functioning; 17% were unable to take long trips with partners; 10% could not visit places without toilets; while 8% were unable to go to the cinema or theatre. Women felt that their partners' prostatic symptoms were also to be blamed for upsetting family relationships (10%) and relationships with friends (16%). There was near total correspondence between women and their male partners regarding the effects of prostatic symptoms. CONCLUSIONS: Prostatism has an impact on men and women; strategies that consider the whole couple should be developed and utilized when considering treatment options.
Asunto(s)
Estilo de Vida , Hiperplasia Prostática/epidemiología , Hiperplasia Prostática/psicología , Calidad de Vida , Esposos/psicología , Comorbilidad , Relaciones Familiares , Femenino , Humanos , Relaciones Interpersonales , Entrevistas como Asunto , Israel/epidemiología , Masculino , Matrimonio/psicología , Persona de Mediana Edad , Disfunciones Sexuales Psicológicas/epidemiología , Disfunciones Sexuales Psicológicas/psicología , Trastornos del Sueño-Vigilia/epidemiología , Trastornos del Sueño-Vigilia/psicología , Encuestas y CuestionariosRESUMEN
We describe our experience using the nocturnal penile tumescence and rigidity monitor (NPTR) in 181 impotent patients referred to the specialized evaluation service in our Family Medicine Center, and review the literature. The 181 patients were referred to the center during 18 months. Their mean age was 53.5 +/- 9.45 years (range 26-76) and 92% were married; about a quarter (26.8%) suffered from impotence for 4-10 years. They were referred by urologists (54.7%), psychiatrists (24.3%), and general practitioners (13.8%). About a third had a normal rigidity, more than half had a normal base tumescence, but only a quarter had normal tip tumescence. Abnormal rigidity and tumescence was significantly associated with diabetes but not with hypertension. We conclude that family physicians have to be actively involved in and responsible for the diagnosis and treatment of impotent patients. Reading and interpreting NPTR is a simple as reading an electrocardiogram and can easily be performed in a primary care setting.
