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Chemistry ; 21(10): 4039-48, 2015 Mar 02.
Artículo en Inglés | MEDLINE | ID: mdl-25641628

RESUMEN

Fluorescent base analogues comprise a group of increasingly important molecules for the investigation of nucleic acid structure, dynamics, and interactions with other molecules. Herein, we report on the quantum chemical calculation aided design, synthesis, and characterization of four new putative quadracyclic adenine analogues. The compounds were efficiently synthesized from a common intermediate through a two-step pathway with the Suzuki-Miyaura coupling as the key step. Two of the compounds, qAN1 and qAN4, display brightnesses (εΦF) of 1700 and 2300, respectively, in water and behave as wavelength-ratiometric pH probes under acidic conditions. The other two, qAN2 and qAN3, display lower brightnesses but exhibit polarity-sensitive dual-band emissions that could prove useful to investigate DNA structural changes induced by DNA-protein or -drug interactions. The four qANs are very promising microenvironment-sensitive fluorescent adenine analogues that display considerable brightness for such compounds.


Asunto(s)
Adenina/química , Colorantes/química , Colorantes Fluorescentes/química , Ácidos Nucleicos/química , Emparejamiento Base , Fluorescencia , Espectrometría de Fluorescencia
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