1.
Dokl Biochem Biophys
; 489(1): 377-379, 2019 Nov.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32130604
RESUMEN
PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.