Hypolipidemic and Hepatoprotective Effects of a Polyprenol-Containing Drug in Patients with Acute Coronary Syndrome.

In a double-blind placebo-controlled trial POLYNCOR (registration No. NCT03122340 at clinicaltrials.gov ), lipid-lowering and hepatoprotective effects of polyprenol-containing drug Ropren were evaluated in patients with acute coronary syndrome. After 2-months therapy, total cholesterol and ALT in the patients receiving Ropren were significantly (p<0.05) lower than in the control group. The number of patients who needed to discontinue or reduce the dose of atorvastatin due to an increase in the level of transaminases in the main group was significantly (p<0.05) lower than in the control group: 0 (0%) vs. 5 (33.3%). The more pronounced decrease in cholesterol level and hepatoprotective effect of Ropren allowed recommending this preparation to patients with acute coronary syndrome in addition to standard therapy.

[Effect of new polyprenol drug ropren on anxiety-depressive-like behavior in rats with experimental Alzheimer disease].

Influence of the chronic administration of ropren (Trademark)--a plant preparation based on the neutral fraction of extract of spruce and pine needles--on affective status in male rats with amyloid peptide (Abeta(25-35)) induced amnesia has been studied. Ropren was administered per os in a dose of 8.6 mg/kg for 28 days. Anxiety, depressive-like behavior, and behavioral reactions were assessed in the elevated plus maze, forced swimming, and open field tests. The four-week treatment revealed significant anxiolytic and antidepressant effects of the drug. Ropren administration improved various behavioral parameters. The obtained results show that ropren ameliorates behavioral deficits in animal model relevant to Alzheimer's disease and indicate that Ropren is potentially active in the management of affective impairments in the experimental model under consideration. It also has a profound beneficial effect on the anxiety and depressive-like behavior in rats with model Alzheimer's type dementia, and thus may prove to be a novel natural treatment.

[Effect of lignins and their model compounds on amine nitrosation in a human gastric juice medium and in the body of mice]. / Vliianie ligninov i nekotorykh ikh model'nykh soedinenii na nitrozirovanie aminov v srede zheludochnogo soka cheloveka i v organizme myshei.

The study was concerned with the influence of lignins of leaf-bearing and coniferous timber and 22 model compounds (lignin components) on nitrosation of dimethylamine, amidopyrine and morpholine in human gastric juice. Some results of the study were confirmed in murine experiments. Compounds of the guaiacyl series showed the highest inhibitory activity. Lignins of coniferous timber proved most effective.