Asunto(s)
Anemia/tratamiento farmacológico , Carnitina/administración & dosificación , Eritropoyetina/uso terapéutico , Fallo Renal Crónico/complicaciones , Administración Oral , Anciano , Anemia/sangre , Anemia/etiología , Progresión de la Enfermedad , Resistencia a Medicamentos , Humanos , Masculino , Proteínas Recombinantes , Diálisis Renal/efectos adversosRESUMEN
The thermolysis of a series of tert-alkyl peroxypivalates 1 in cumene has been investigated by using the nitroxide radical-trapping technique. tert-Alkoxyl radicals generated from the thermolysis underwent the unimolecular reactions, beta-scission, and 1,5-H shift, competing with hydrogen abstraction from cumene. The absolute rate constants for beta-scission of tert-alkoxyl radicals, which vary over 4 orders of magnitude, indicate the vastly different behavior of alkoxyl radicals. However, the radical generation efficiencies of 1 varied only slightly, from 53 (R = Me) to 63% (R = Bu(t)()), supporting a mechanism involving concerted two-bond scission within the solvent cage to generate the tert-butyl radical, CO(2), and an alkoxyl radical. The thermolysis rate constants of tert-alkyl peroxypivalates 1 were influenced by both inductive and steric effects [Taft-Ingold equation, log(rel k(d)) = (0.97 +/- 0. 14)Sigmasigma - (0.31 +/- 0.04)SigmaE(s)(c), was obtained].
RESUMEN
BACKGROUND: The authors analyzed the radiation dose to the periphery of the cervix and area of the cervix in relation to local failure of radiotherapy for carcinoma of the cervix using computed tomography (CT) images. METHODS: Between 1981-1990, 127 consecutive patients were treated with definitive radiotherapy. Ninety-nine of these patients had CT images taken at the time of intracavitary therapy. Of these 99 patients, 80 were eligible for this analysis. After CT scanning, isodose curves relative to the point A dose were superimposed on the CT images. The minimum percent dose and minimum dose at the periphery of the cervix were estimated. The area of the cervix also was measured. These factors were examined in relation to the local tumor control rate. RESULTS: Histograms of both the minimum percent dose and the cervical area showed significant differences between the local control and local failure groups (P <0.001). The local control rates were related to both the minimum percent dose and the cervical area, and differed significantly over and below the values of 60% and 18 cm2 (P <0.001 each), respectively. The local control patients, over and below the line: Y = -0.220X + 21.2, in which X (gray [Gy]) and Y (Gy) are the whole pelvis dose and the minimum dose, respectively, could be well differentiated with significance (91.7% vs. 25.0%; P <0.001). CONCLUSIONS: Computed tomography analysis indicated that the local tumor control rate was related strongly to the minimum percent dose, the cervical area, and the pair of whole pelvis and minimum dose values. These factors were found to be more useful than the point A dose in predicting local tumor control.
Asunto(s)
Braquiterapia , Neoplasias del Cuello Uterino/radioterapia , Adulto , Anciano , Anciano de 80 o más Años , Relación Dosis-Respuesta en la Radiación , Femenino , Humanos , Persona de Mediana Edad , Recurrencia Local de Neoplasia , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Insuficiencia del Tratamiento , Neoplasias del Cuello Uterino/diagnóstico por imagenRESUMEN
Since most clinical radiotherapy is given as multiple small irradiation fractions, the present study was undertaken to test the in vivo radiosensitizing activity of a new hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation. Radiosensitizing activity was measured by a growth delay assay using a transplanted mammary tumor in C3H/He mice, and by an in vivo-in vitro assay using the SCC VII tumor. KU-2285 was injected intraperitoneally 30 min before irradiation in all experiments. The in vivo-in vitro assay using SCC VII tumors showed that 12.5 micrograms/g of KU-2285 sensitized the tumors to irradiation (5 Gy/fr x 5 fr/48 hr or 6 Gy/fr x 3 fr/48 hr). KU-2285 also sensitized the transplanted mammary tumors to fractionated irradiation. We concluded that KU-2285 was able to sensitize two different murine tumors when given in combination with radiation dose fractionation.
Asunto(s)
Nitroimidazoles/farmacología , Fármacos Sensibilizantes a Radiaciones/farmacología , Animales , Carcinoma de Células Escamosas/radioterapia , Supervivencia Celular/efectos de la radiación , Femenino , Neoplasias Mamarias Experimentales/radioterapia , Ratones , Ratones Endogámicos C3H , Trasplante de Neoplasias , Dosificación RadioterapéuticaAsunto(s)
Calor/uso terapéutico , Neoplasias Mamarias Experimentales/terapia , Misonidazol/uso terapéutico , Nitroimidazoles/uso terapéutico , Tolerancia a Radiación , Fármacos Sensibilizantes a Radiaciones/uso terapéutico , Animales , Femenino , Ratones , Ratones Endogámicos C3H , Dosificación RadioterapéuticaRESUMEN
The mean rate of blood flow in C3H/He mouse mammary carcinoma determined by the clearance of 133Xe was 0.1 ml/g/min in tumors greater than approximately 2.0 cm3, and then blood flow became increasingly greater as the tumor size decreased further. The dose required to produce lethal damage in the tumor increased with the size of the tumors. In large tumors the control rate increased with increasing doses to a maximum at a certain level; at higher doses the rate was somewhat decreased. The present experiments show that changes in blood flow could account for radiosensitivity of the tumor, and a tumor larger than a certain volume can no longer be controlled by a single dose of radiation.